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1. Gating mechanisms of a natural anion channelrhodopsin.
... Gating mechanisms of a natural anion channelrhodopsin. ... Anion channelrhodopsins (ACRs) are a class of light-gated channels recently identified in cryptophyte algae that provide unprecedented fast and powerful hyperpolarizing tools for optogenetics. ... The first mechanism, characterized by slow opening and fast closing of the channel, is regulated by Glu-68. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=26578767 -- 4.8 Кб -- 09.04.2016
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2. Low Concentrations of Hydrogen Peroxide Activate the Antioxidant Defense System
... Low Concentrations of Hydrogen Peroxide Activate the Antioxidant Defense System in Human Sperm Cells. ... The effect of low concentrations of hydrogen peroxide (10-100 microM) on sperm motility and on the activity of the sperm enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDS) was investigated. ... Thus, the increase in motile spermatozoa in the presence of low concentrations of hydrogen peroxide can serve as an indicator of normal functioning of the antioxidant defense system in sperm cells. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=26555470 -- 4.6 Кб -- 09.04.2016
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3. In Vitro Demonstration of Dual Light-Driven Na(+)/H(+) Pumping by a Microbial
... In Vitro Demonstration of Dual Light-Driven Na(+)/H(+) Pumping by a Microbial Rhodopsin. ... A subfamily of rhodopsin pigments was recently discovered in bacteria and proposed to function as dual-function light-driven H(+)/Na(+) pumps, ejecting sodium ions from cells in the presence of sodium and protons in its absence. ... Therefore, an in vitro system consisting of the purified pigment in the absence of other proteins was needed to assign the putative Na(+) and H(+) transport definitively. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=26445445 -- 5.2 Кб -- 09.04.2016
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4. Disruption of Amyloid Prion Protein Aggregates by Cationic Pyridylphenylene
... Disruption of Amyloid Prion Protein Aggregates by Cationic Pyridylphenylene Dendrimers. ... Here, for the first time we report that pH-independent cationic pyridylphenylene dendrimers are able to disrupt amyloid protein aggregates at physiological pH as exemplified by inclusion bodies of ovine prion protein. The results show that exposure of inclusion bodies to the dendrimers leads to its partial disaggregation and release of the nanosize protein-dendrimer complexes. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=26445143 -- 4.0 Кб -- 09.04.2016
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5. Culturing of Mouse Mesenchymal Stem Cells on Poly-3-Hydroxybutyrate Scaffolds.
... Culturing of Mouse Mesenchymal Stem Cells on Poly-3-Hydroxybutyrate Scaffolds. ... 2015 Aug;159(4):567-71. doi: 10.1007/s10517-015-3015-5. ... We studied the possibility of long-term culturing of mouse mesenchymal stem cells on a porous scaffold made of biocompatible polymer poly-3-hydroxybutyrate. ... Culturing on the scaffold did not change surface phenotype of cells. 3D poly-3-hydroxybutyrate scaffolds are appropriate substrate for long-term culturing of mesenchymal stem cells. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=26388561 -- 4.1 Кб -- 09.04.2016
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6. Binding of ouabain and marinobufagenin leads to different structural changes in
... Binding of ouabain and marinobufagenin leads to different structural changes in Na,K-ATPase and depends on the enzyme conformation. ... We have shown that both CTS inhibit activity of Na,K-ATPase with the same Ki values, but binding of ouabain is sensitive to the conformation of Na,K-ATPase while binding of marinobufagenin is not. Furthermore, binding of ouabain and marinobufagenin results in different structural changes in Na,K-ATPase. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=26297827 -- 4.2 Кб -- 09.04.2016
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7. NEUROSCIENCE. Natural light-gated anion channels: A family of microbial
... NEUROSCIENCE. Natural light-gated anion channels: A family of microbial rhodopsins for advanced optogenetics. ... We describe anion channel rhodopsins (ACRs), a family of light-gated anion channels from cryptophyte algae that provide highly sensitive and efficient membrane hyperpolarization and neuronal silencing through light-gated chloride conduction. ... Natural ACRs provide optogenetic inhibition tools with unprecedented light sensitivity and temporal precision. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=26113638 -- 4.3 Кб -- 09.04.2016
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8. Critical role of the alpha1-Na(+), K(+)-ATPase subunit in insensitivity of
... Critical role of the alpha1-Na(+), K(+)-ATPase subunit in insensitivity of rodent cells to cytotoxic action of ouabain. ... In 24, 3 muM ouabain triggered the death of all types of human cells used in this study. ... Overall, our results, demonstrate that the drastic differences in cytotoxic action of ouabain on human and rodent cells are caused by unique features of alpha1S/alpha1R-Na(+), K(+)-ATPase, rather than by any downstream CTS-sensitive/resistant components of the cell death machinery. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=26067145 -- 5.2 Кб -- 09.04.2016
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9. Characterization of endogenously circulating IGFBP-4 fragments-Novel biomarkers
... Characterization of endogenously circulating IGFBP-4 fragments-Novel biomarkers for cardiac risk assessment. ... BACKGROUND: Recent findings show that circulating N- and C-terminal fragments of IGF-binding protein-4 (NT-IGFBP-4 and CT-IGFBP-4) can be utilized as biomarkers for cardiac risk assessment in acute coronary syndrome (ACS) patients. ... However, properties of the endogenous IGFBP-4 fragments that could influence the performance of the immunoassays were still not investigated. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=26025773 -- 5.5 Кб -- 09.04.2016
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10. Structural basis for the NAD binding cooperativity and catalytic
... Structural basis for the NAD binding cooperativity and catalytic characteristics of sperm-specific glyceraldehyde-3-phosphate dehydrogenase. ... We exploited mammalian glyceraldehyde-3-phosphate dehydrogenase as a model protein and examined the structural basis of the NAD(+) cooperative binding exhibited by its homologous isoenzymes: the somatic enzyme (GAPD) and the recombinant sperm-specific enzyme (dN-GAPDS). ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=25936797 -- 4.5 Кб -- 09.04.2016
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11. Structural basis for regulation of stability and activity in
... Structural basis for regulation of stability and activity in glyceraldehyde-3-phosphate dehydrogenases. Differential scanning calorimetry and molecular dynamics. ... Tissue specific isoforms of human glyceraldehyde-3-phosphate dehydrogenase, somatic (GAPD) and sperm-specific (GAPDS), have been reported to display different levels of both stability and catalytic activity. Here we apply MD simulations to investigate molecular basis of this phenomenon. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=25869789 -- 5.1 Кб -- 09.04.2016
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12. Attempt to optimize some properties of fluorescent chimeras of human small heat
... Attempt to optimize some properties of fluorescent chimeras of human small heat shock protein HspB1 by modifying linker length and nature. ... Chimerical proteins consisting of enhanced yellow fluorescent protein (EYFP) connected by linkers of different length and nature to the N-terminal end of small heat shock protein HspB1 were obtained and characterized. ... Long flexible linkers should be used to obtain fluorescent chimeras with chaperone-like properties similar to those of the wild-type HspB1....
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=25754041 -- 5.1 Кб -- 09.04.2016
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13. Upstream open reading frames regulate translation of the long isoform of SLAMF1
... Upstream open reading frames regulate translation of the long isoform of SLAMF1 mRNA that encodes costimulatory receptor CD150. ... More than 40% of human genes contain upstream open reading frames (uORF) in their 5'-untranslated regions (5'-UTRs) and at the same time express at least one truncated mRNA isoform containing no uORF. ... CD150 is a member of the CD2 superfamily, a costimulatory lymphocyte receptor, a receptor for measles virus, and a microbial sensor on macrophages. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=25716736 -- 5.1 Кб -- 09.04.2016
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14. Low-temperature (77 K) phosphorescence of triplet chlorophyll in isolated
... Low-temperature (77 K) phosphorescence of triplet chlorophyll in isolated reaction centers of photosystem II. ... 2015 Aug;125(1-2):43-9. doi: 10.1007/s11120-015-0105-1. Epub 2015 Feb 25. ... The phosphorescence intensity strongly depends upon the redox state of RCs. The data suggest that the phosphorescence signal originates from the chlorophyll triplet state populated via charge recombination in the radical pair [Formula: see text]. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=25712165 -- 4.0 Кб -- 09.04.2016
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15. [Isotopic effects of low concentration of deuterium in water on biological
... Isotopic effects of low concentration of deuterium in water on biological systems]. ... Isotopic effects of deuterium in water are studied in a broad range of concentrations on a number of biological objects of different organization levels. ... A decrease or increase in deuterium concentrations in water may cause activation or inhibition of biological functions. The values of biological isotopic effects of low deuterium concentration may even be higher than those of high deuterium concentration. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=25702494 -- 3.9 Кб -- 09.04.2016
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16. [application of the analytical transmission electron microscopy techniques for
... application of the analytical transmission electron microscopy techniques for detection, identification and visualization of localization of nanoparticles of titanium and cerium oxides in mammalian cells]. ... This work represents the results of the study on applicability of the modern methods of analytical transmission electron microscopy for detection, identification and visualization of localization of nanoparticles of titanium and cerium oxides in A549 cell, human lung adenocarcinoma cell line. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=25702487 -- 5.1 Кб -- 09.04.2016
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17. GAPDH binders as potential drugs for the therapy of polyglutamine diseases:
... GAPDH binders as potential drugs for the therapy of polyglutamine diseases: design of a new screening assay. ... Proteins with long polyglutamine repeats form a complex with glyceraldehyde-3-phosphate dehydrogenase (GAPDH), which enhances aggregation and cytotoxicity in models of Huntington disease. ... The feasibility of the new assay was verified using two GAPDH binders, hydroxynonenal and -(-)deprenyl, and the benzothiazole derivative PGL-135 which exhibits anti-aggregation effect. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=25625921 -- 4.4 Кб -- 09.04.2016
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18. Sulfated and sulfonated polymers are able to solubilize efficiently the protein
... Sulfated and sulfonated polymers are able to solubilize efficiently the protein aggregates of different nature. ... The present work describes a new approach to solubilizing pre-formed protein aggregates with sulfated or sulfonated polymers (polysulfoanions). For the first time it was shown that polysulfoanions are capable of solubilizing amorphous and amyloid protein inclusion bodies as well as thermal aggregates. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=25562403 -- 4.5 Кб -- 09.04.2016
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19. [The use of immobilized ubiquitin for biosensor analysis of the mitochondrial
... The use of immobilized ubiquitin for biosensor analysis of the mitochondrial subinteractome]. ... In the context of protein-protein interactions binding of (mono/poly)ubiquitinated molecules to proteins containing specific ubiquitin binding domains appear to play the decisive role. ... In this study using an optical biosensor we have demonstrated binding of proteins of mouse brain mitochondrial lysates to immobilized monomeric ubiquitin. ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=25552499 -- 4.5 Кб -- 09.04.2016
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20. The effects of endogenous non-peptide molecule isatin and hydrogen peroxide on
... The effects of endogenous non-peptide molecule isatin and hydrogen peroxide on proteomic profiling of rat brain amyloid-beta binding proteins: relevance to Alzheimer's disease? ... The effects of hydrogen peroxide and isatin have been confirmed in optical biosensor experiments with purified glyceraldehyde-3-phosphate dehydrogenase, one of the known crucial amyloid-beta binding proteins (also identified in this study). ...
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Ссылки http://biochem.bio.msu.ru/publications/publication.php?pubmedID=25551598 -- 5.3 Кб -- 09.04.2016
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