... Individual SELEX products, aptamers, are small molecules (40100 nt) that have a unique three-dimensional structure, which provides for their specific and high-affinity binding to targets varying from low-molecular-weight ligands to proteins. ... Selection of aptamers binding with a target is the key step in SELEX, as aptamers account for only a small fraction of the initial library (one aptamer per 109 to 1013 molecules) [6]. ... Fourth, modification can increase the aptamer affinity for a target. ...
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Ссылки http://rnp-group.genebee.msu.su/pdfs/MolBio6_00KopylovLO.pdf -- 375.6 Кб -- 21.10.2002
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Decision of a Very Important Problem[1] A.A. Ivanov University of Moscow Text: Times New Roman, 11pt. For formulas, please, use MS Equation or MathType with font Times New Roman, 11pt. ----------------------- [1] Acknowledgments if necessary
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