... 2004 Nov, v. 69, N11, p.1252-67(Engl), 1537-1554(Rus). Catalytic mechanism and application of formate dehydrogenase. ... NAD+-dependent formate dehydrogenase (FDH) is an abundant enzyme that plays an important role in energy supply of methylotrophic microorganisms and in response to stress in plants. ... This review covers the late developments in cloning genes of FDH from various sources, studies of its catalytic mechanism and physiological role, and its application for new chiral syntheses. ...