[ХФ+БФ]применение ДМСО+этанол(закрыто) - Public forum of MSU united student networks

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Pharm Dev Technol. 2007;12(2):169-74. Transdermal permeability of N-acetyl-D-glucosamine.
Garner ST Jr, Israel BJ, Achmed H, Capomacchia AC, Abney T, Azadi P.

Department of Pharmaceutical and Biomedical Sciences, The University of Georgia, Atlanta, GA 30602, USA.
Transdermal permeation of N-acetyl-D-glucosamine (NAG), a metabolite of glucosamine was examined. Glucosamine salts are nutraceuticals used in the oral treatment of osteoarthritis. Sparse information is available regarding glucosamine and NAG transdermal or percutaneous transport and absorption. Permeability of NAG in various enhancer suspensions was evaluated by using shed snakeskin as a model membrane via Franz-type cell diffusion studies. Negligible permeability was observed for NAG in neat solutions of known membrane permeation enhancers ethanol, oleic acid, isopropyl myristate, and isopropyl palmitate, as well as from saturated solutions of NAG in water or phosphate buffer. Permeability measurements obtained from saturated solutions of NAG in DMSO and phosphate buffer solutions containing ethanol at 2%, 5%, 10%, 25%, and 50% demonstrated excellent permeation. Permeability coefficients of the phosphate buffer/ethanol solutions at 5%, 10%, and 25% were about threefold larger in value as those for saturated DMSO solution, whereas the 2% and 50% solution values were lower.
PMID: 17510888 [PubMed - indexed for MEDLINE]

Hum Exp Toxicol. 2006 Dec;25(12):715-21.Evaluation of the effects of hydrophilic organic solvents on CYP3A-mediated drug-drug interaction in vitro.
Iwase M, Kurata N, Ehana R, Nishimura Y, Masamoto T, Yasuhara H.

Department of Pharmacology, School of Medicine, Showa University, Tokyo, Japan. marisuke@med.showa-u.ac.jp
This study evaluated the effects of the commonly used hydrophilic organic solvents, acetonitrile, methanol, ethanol, 1-propanol, dimethyl sulfoxide (DMSO), N,N-dimethylformamide, polyethylene glycol and propylene glycol, on CYP3A in pooled human liver microsomes, using testosterone and midazolam as substrates. Furthermore, we examined the modulation effect of organic solvents on CYP3A inhibition by ketoconazole. Testosterone 6beta-hydroxylation activity was potently inhibited in the presence of DMSO and 1-propanol in a concentration-dependent manner. Midazolam 1'-hydroxylation activity, however, was weakly inhibited only by 1% of DMSO, the highest concentration used in this study. Moreover, the potency of ketoconazole to inhibit CYP3A activities was variable, depending on the organic solvent used as a dissolving solvent for ketoconazole. Our data indicate that each organic solvent had an effect on CYP3A4 activity, evaluated by both substrates with different magnitudes. Furthermore, it was shown that the effects of organic solvents on CYP3A activity are substrate-dependent. The present study also shows that methanol had little effect on either substrate.

PMID: 17286149 [PubMed - indexed for MEDLINE]

Мне почему-то кажется, что объяснение уже было дано. Плюс посмотри на ссылки выше. Влияние на CYP со стороны побочных компонентов лекарств уже давно обсуждается