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Burden, C. J., Pittelkow, Y. and Wilson, S. R. // J. Phys.: Condens. Matter. -- 2006. -- Vol. 18. -- P. 55455565. Burden, C.J., Pittelkow, Y.E., Wilson, S.R. // Stat. Appl. Genet. Mol. Biol. -- 2004. -- Vol. 3. -- Article 35. Carlon, E., Heim, T. // Physica A. -- 2006. -- Vol. 362. -- P. 433449. Halperin, A., Buhot, A., Zhulina, E.B. // Clin. Chem. -- 2004. -- Vol. 7. -- P. 22542262. Hekstra, D., Taussig, A.R., Magnasco, M., Naef, F. // Nucleic Acids Res. -- 2003. -- Vol. 31. -- P. 19621968. Hooyberghs, J., Van Hummelen, P. and Carlon, E. // Nucleic Acids Research. -- doi:10.1093/nar/gkp109. Kozal, M. J., Shah, N., Shen, N., Yang, R., Fucini, R., Merigan, T. C., Richman, D. D., Morris, D., Hubbell, E., Chee, M. and Gingeras, T. R. // Nature Medicine. -- 1996. -- Vol. 2. -- P. 753759. Levicky, R., Horgan, A. // Trends Biotechnol. -- 2005. -- Vol. 23. -- P. 143149. Mei, R., Hubbell, E., Bekiranov, S., Mittmann, M., Christians, F.C., Shen, M.M., Lu, G., Fang, J., Liu, W.M., Ryder, T., Kaplan, P., Kulp, D., Webster, T.A. // Proc. Natl. Acad. Sci. USA. -- 2003. -- Vol. 100. -- P. 1123711242. Mikhailovich, V., Gryadunov, D., Kolchinsky, A., Makarov, A.A.; Zasedatelev, A. // BioEssays: news and reviews in molecular, cellular and developmental biology. -- 2008. -- Vol. 30, no. 7. -- P. 67382.
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Schena, M., Shalon, D., Davis, R.W., Brown, P.O. // Science. -- 1995. -- Vol. 270. -- P. 46770. Zhang, Y., Hammer, D.A., Graves, D.J. // Biophys. J. -- 2005. -- Vol. 89. -- P. 29502959.

PHYSICO-MATHEMATICAL MODELLING OF TARGET-PROBE BINDING ON MICROCHIPS AT BIOLOGICAL AND MEDICAL INVESTIGATIONS Golovkin M. V., Matveeva O. V., Nechipurenko Yu. D.

The process of microarray oligo-target hybridization was modeled using equilibrium adsorption. The relationship between hybridization signal intensity and Gibbs free energy change for oligo-target duplex formation was our function of interest. The equilibrium adsorption model predicts S-shaped functional relationship between these two variables. We called the respective curve Energetic Hybridization Isotherm (EHI). It was demonstrated that change of target/probe ratio could result in shifts of the inflection point of Sshaped EHI curve along both axes. This study provides insights into EHI curves' behavior observed in microarray experiments.

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