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Project Leader: Pavel P. PHILIPPOV, Dr. of Science (Biolology), Professor of Biochemistry, Head of the Department of Enzymology, A.N.Belozersky Institute of Physico-Chemical Biology, Moscow State University. Address: A.N.Belozersky Institute of Physico-Chemical Biology, Moscow State University, 119899 Moscow, Russia. Tel.: 7(095) 939-50-17, fax: 939-09-78. E-mail: < ppph@genebee.msu.su > Main research directions of the Department: 1. Calcium-binding protein, recoverin and other paraneoplastic antigens as potential markers of cancer. 2. Molecular mechanisms of visual transduction. Main scientific results: 1. Prediction of the existence of the transducin GTPase activator in rod outer segments [Arshavsky V.Yu., Antoch M.P., Lukjanov K.A., Philippov P.P. (1989) FEBS Lett. 250, 353-356]. 2. Discovery of the novel visual Ca2+-binding protein, recoverin and its ability to bind to membranes in a Ca2+-dependent manner [Dizhoor A.M., Nekrasova E.R., Philippov P.P. (1991) Biochemistry (Moscow) 56, 225-229; Dizhoor et al. (1991) Science 251, 915-918; Dizhoor et al. (1993) Science 259, 829-832]. 3. Identification of rhodopsin kinase as the recoverin intracellular target [Gorodovikova E.N., Philippov P.P (1993) FEBS Lett. 335, 277-279; Gorodovikova E.N. et al. (1994) FEBS Lett. 349, 187-190; Gorodovikova E.N., Senin I.I., Philippov P.P (1994) FEBS Lett. 353, 171-172]. Honours, Distinctions and Grants: 1981 Government Award for the Applied Work in Biotechnology (Russia). 1990-91 Grant (fellowship) of CNRS (France). 1992-95 Grant of the International Human Frontier Science Program Organization. 1994-95 Grant of the International Science Foundation. 1994-97 Grant of the Royal Society (UK). 1997 Yu.A.Ovchinnikov Award of the Russian Academy of Sciences. 1997,98 Professorship of the International Soros Scince Education Program. 1999 Annual Bakh’s Lecture, the Russian Academy of Sciences. 1998-01 Grant of the Wellcome Trust (UK). 1994-96, Fellowship of the President of Russia for Outstanding Scientists. 1997-99, 2000-02 1994-96, Grant of the Russian Foundation for Basic Research. 1997-99, 2000-02 2000-02 Grant of the Ludwig Institute for Cancer Research.