Äîêóìåíò âçÿò èç êýøà ïîèñêîâîé ìàøèíû. Àäðåñ îðèãèíàëüíîãî äîêóìåíòà : http://www.chem.msu.ru/eng/misc/babaev/papers/087r.pdf Äàòà èçìåíåíèÿ: Thu Jan 20 22:01:32 2011 Äàòà èíäåêñèðîâàíèÿ: Sat Feb 12 03:10:50 2011 Êîäèðîâêà: ISO8859-5

ôúðûýÔóóùÙúÔþð?, 2003, êãß 48, < 6, â. 1008-1018

ûýúüôýüúÔ ùúÙÔ÷ð?æûôðÿ ûùæáð÷æ÷ðò
üáô 548.73;547.7

úæ÷ýÙæ÷ùûýúüôýüú÷ùæ ôÔúýðúù×Ô÷ðæ × Ùæýæúùåðôóð?æûôùõ áðñÔò÷æ. 12. úæ÷ýÙæ÷áðþúÔôåðù÷÷ùæ ðûûóæáù×Ô÷ðæ øðúðáù÷ù×-2, ûùáæúìÔ?ðÿ Ô÷÷æóðúù×Ô÷÷?ò øù û×?ñð û(5)-û(6) þúÔÙõæ÷ý åðôóùÔóôÔ÷ù×
? 2003 ,,. á. ×. ÔÞÈÇã,, ù. û. õÑÛÜ, ×. Õ. úÀÇÝã,, æ. ×. ÕÇÒ,, ×. ×. ?ÒÜÀ?Ò,, ó. Ô. ÔâÞÜã,
õãâÝã,âÝÛØ ,,ãâëâê,ÒÜÜÀØ ëÜÛ,ÒâÛêÒê Ûß. õ. ×. óãßãÜãâã, E-mail: albov@biocryst.phys.msu.su
øãâêëäÛÞ , ÒÝ^Û 23.01.2003 ,,.

õÒêããß ßãÜãÝÛâêÞÈÜãØ ÛéÝ^ÛÛ ÛââÞÒã,ÜÀ âêëÝêëÀ 4,6-ÛßÒêÛÞ-1÷-äÛÛÛÜ-2-ãÜ (a = 6.125(2), b = 15.153(4), c = 14.477(4) Õ, Z = 8, ä. ,,. Pbca), ÝãßäÞÒÝâ 4-ßÒêÛÞ-1,5,6,7-êÒê,,Ûã-2÷^ÛÝÞãäÒÜê[b]äÛÛÛÜ-2-ãÜ â éãâéãÜãØ ÝÛâÞãêãØ Û ßÒêÜãÞãß âãâê, 2 : 1 : 1 (a = 11.181(2), b = 14.059(6), c = 13.593(4) Õ, = 97.78(2)À, Z = 8, ä. ,,. P21/n), 4-ßÒêÛÞ-1,5,6,7,8,9-,,ÒÝâ,,Ûã-2÷-^ÛÝÞã,,Òäê[b]äÛÛÛÜ-2-ãÜ (a = 12.565(6), b = 5.836(6), c = 13.007(3) Õ, = 93.10(3)À, Z = 4, ä. ,,. P21/n) Û 4-ßÒêÛÞ-5,6,7,8,9,10-,,ÒÝâ,,Ûã^ÛÝÞããÝê[b]äÛÛÛÜ-2(1÷)-ãÜ (a = 12.955(3), b = 6.1595(15), c = 13.038(3) Õ, = 95.50(2)À, Z = 4, ä. ,,. P21/n). ûêëÝêëÀ Ò?ÒÜÀ äflßÀßÛ ßÒêãßÛ Û ëêã~ÜÒÜÀ äãÞÜãßêÛ~ÜÀß õ÷ô , ÜÛÑãêãäÜãß äÛÇÞÛÚÒÜÛÛ âããê,Òêâê,ÒÜÜã ã R = 0.0755, R = 0.0644, R = 0.0754, R = 0.0569. õÒêããß äãã?Ýã,ãØ ÛéÝ^ÛÛ ÛââÞÒã,ÜÀ âêëÝêëÀ 4-ßÒêÛÞ-1.5,6.7-êÒê,,Ûã-2÷-^ÛÝÞãäÒÜê[b]äÛÛÛÜ-2-ãÜ (a = 7.353(4), b = 8.176(4), c = 13.00(1) Õ, = 105.64(2)À, Z = 4, ä. ,,. P21/c) Û 2-ãÝâã-2,5,6,7,8-,,ÒÝâ,,ÛãiÛÜãÞÛÜ-3-ÝÇãÜÛêÛÞ (a = 5.9870(2), b = 16.5280(5), c = 9.6540(3) Õ, = 111.52(4)À, Z = 4, ä. ,,. P21/c). ûêëÝêëÀ ãäÒÒÞÒÜÀ ßÒêããß âÛâêÒßêÛ~ÒâÝã,,ã äãÛâÝ, ëêã~ÜÒÜÛÒ äã,ãÛÞãâÈ ßÒêããß úÛê,ÒÞÈ âããê,Òêâê,ÒÜÜã ã Rwp = 0.108, Rexp = 0.032, Rp = 0.076, Rb = 0.123, 2 = 7.9 Û Rwp = 0.058, Rexp = 0.027, Rp = 0.043, Rb = 0.077, 2 = 3.64. ×ã ,âÒi âêëÝêëi ãêßÒ~ÒÜã ãÇÑã,ÜÛÒ ,ãããÜÀi â,flÑÒØ â ë~âêÛÒß êãßã, N, H Û O äÛÛãÜã,ã,,ã é,,ßÒÜê.

××æáæ÷ðæ` áÜÜfl Çãê fl,ÞflÒêâfl äããÞÚÒÜÛÒß äã,ãÛßÀi âêëÝêëÜÀi ÛââÞÒã,ÜÛØ ,,ÒêÒã^ÛÝÞÛ~ÒâÝÛi âãÒÛÜÒÜÛØ, ãÇÞÛi âäãâãÇÜãâêÈ ,âêëäêÈ , ÑÞÛ~ÜÀÒ äÒÒ,,ëääÛã,ÝÛ, , êãß ~ÛâÞÒ Û ÒÝ^ÛÛ ^ÛÝÞÛÑ^ÛÛ [1-12]. ôÝ Û , äÒÀëÛi âããÇÒÜÛfli, ßÀ äãâÞÒã,êÒÞÈÜã ÛÑë~Òß ßÒêããß ÒÜê,,ÒÜãâêëÝêëÜã,,ã ÜÞÛÑ âêãÒÜÛÒ ,âÒi ÛÜêÒßÒÛêã, Û ÝãÜÒ~ÜÀi äãëÝêã, ßÜã,,ãâêëäÒÜ~êÀi ÒÝ^ÛØ ^ÛÝÞÛÑ^ÛØ Û äÒÒ,,ëääÛã,ãÝ. ûêëÝêëÜÀßÛ äÒ?Òâê,ÒÜÜÛÝßÛ ßÜã,,Ûi âÛâêÒß, ÛÑë~ÒÜÜÀi ÜßÛ ÜÒÒ, fl,Þflêâfl äãÛÑ,ãÜÀÒ äÛÛãÜ-2 (âiÒß 1). × ÜâêãflÒØ ÇãêÒ ßÀ ÛÑë~ÛÞÛ
H H C C C H
5 6 4

C C

H
3 2

âêãÒÜÛÒ 4,6-ÛßÒêÛÞ-1÷-äÛÛÛÜ-2-ãÜ (I) Û fl Ò,,ã ÜÞã,,ã,, âãÒÚÛi ÜÜÒÞÛã,ÜÜÀØ äã â,flÑÛ û(5)-û(6) ^ÛÝÞãÞÝÜã,ÀØ é,,ßÒÜê, ÛßÒÜÜã 4-ßÒêÛÞ-1,5,6,7-êÒê,,Ûã-2÷-^ÛÝÞãäÒÜê[b]äÛÛÛÜ-2-ãÜ (IIa), Ò,,ã ÝãßäÞÒÝâ â éãâéãÜãØ ÝÛâÞãêãØ Û ßÒêÜãÞãß âãâê, 2 : 1 : 1 (II), 4-ßÒêÛÞ-1,5,6,7,8,9-,,ÒÝâ,,Ûã-2÷-^ÛÝÞã,,Òäê[b]äÛÛÛÜ-2-ãÜ (III), 4-ßÒêÛÞ-5,6,7,8,9,10-,,ÒÝâ,,Ûã^ÛÝÞããÝê[b]-äÛÛÛÜ-2(1÷)-ãÜ (IV) Û 2ãÝâã-1,2,5,6,7,8-,,ÒÝâ,,ÛãiÛÜãÞÛÜ-3-ÝÇã-ÜÛêÛÞ (V). áÜÜÀÒ ã âêãÒÜÛÛ ßãÞÒÝëÞ , ÝÛâêÞÞi âãÒÛÜÒÜÛØ, ãÇâëÚÒßÀi , ÜâêãflÒØ âêêÈÒ, , ôÒßÇÛÚâÝãß ÇÜÝÒ âêëÝêëÜÀi ÜÜÀi (,ÒâÛfl 11.02) ãêâëêâê,ëê [13]. ?ôûøæúðõæ÷ýÔó?÷Ô? ?Ôûý? ûÛÜêÒÑ âãÒÛÜÒÜÛØ ãâëÒâê,ÞÒÜ äã âiÒßß:

N

1

O

H ûiÒß 1 1008


úæ÷ýÙæ÷ùûýúüôýüú÷ùæ ôÔúýðúù×Ô÷ðæ CH
3

1009 CH
3

N + NH
2

CH

3

N
H2SO4

O CH
3

O

O

CH

3

NH

O

CH

3

NH I

O

ûiÒß 2 CH + O O NH
2 3
(HPO3)n

CH 2 NH II

3

CH Ç H3PO4 Ç CH3OH O
NaOH

3

O

NH IIa CH
3

O

ûiÒß 3 CH3 + O O NH
2

O

NH III

O

ûiÒß 4 CH3 + O O NH
2

CH

3

O

NH IV

O

ûiÒß 5 O O + H O MeONa EtONa EtOH O- Na
NH
+

O CN
2

CN N V O

O

Pipy*Ac H2O

ûiÒß 6

ûãÒÛÜÒÜÛÒ I äãÞë~ÒÜã äã ßÒêãÛÝÒ [14]. ûÛÜêÒÑ âãÒÛÜÒÜÛØ II, III Û IV ,ÀäãÞÜÒÜ äã ÛÑßÒÜÒÜÜãØ ßÒêãÛÝÒ [15]: 16 ,, ^Òêã^ÒêßÛ, Ý,ÛßãÞflÜãÒ ÝãÞÛ~Òâê,ã âããê,Òêâê,ëÒ,,ã ^ÛÝÞãÞÝÜã-

Ü Û 80 ,, äãÞÛéãâéãÜãØ ÝÛâÞãêÀ ãâêããÚÜã Ü,,Ò,ê äÛ äÒÒßÒ?Û,ÜÛÛ âêÒÝÞflÜÜãØ äÞã~ÝãØ , âêÝÜÒ. øÛ êÒßäÒêëÒ ãÝãÞã 70Àû Ü~ÛÜÒêâfl ÝÑãêÒßÛ~ÒâÝfl ÒÝ^Ûfl Û âßÒâÈ ßã-

ýÇÞÛ^ 1. þÛÑÛÝã-iÛßÛ~ÒâÝÛÒ iÝêÒÛâêÛÝÛ äãÞë~ÒÜÜÀi âãÒÛÜÒÜÛØ ûãÒÛÜÒÜÛÒ I IIa III IV V TäÞ, ÀC 180-182 245-248 258-260 230-233 250-257 øõú 6.04 (1H, c, C(5)H); 5.92 (1H, c, C(3)H); 2.23 (3H, c, 6-CH3); 2.13 (3H, c, 4-CH3) (^ÒêãÜ-d6) 5.87 (1H, c, C(3)H); 2.72 (2H, ê, C(8)H2); 2.61 (2H, ê, C(6)H2); 2.06 (3H, c, C(10)H3); 2.04 (2H, ß, C(7)H2) (áõûù-d6) 5.88 (1H, c, C(3)H); 2.62 (2H, ê, C(10)H2); 2.48 (2H, ê, C(6)H2); 2.08 (3H, c, C(12)H3); 1.78 (2H, ß, C(9)H2); 1.54 (4H, ß, C(7)H2, C(8)H2) (áõûù-d6) 5.99 (1H, c, C(3)H); 2.58 (2H, ê, C(11)H2); 2.46 (2H, ê, C(6)H2); 2.09 (3H, c, C(13)H3); 1.59 (2H, ß, C(10)H2); 1.51 (2H, ß, C(7)H2); 1.34 (4H, ß, C(8)H2), C(9)H2) (áõûù-d6) 7.87 (1H, c, C(4)H); 2.56 (2H, ê, C(7)H2); 2.43 (2H, ê, C(9)H2); 1.66 (4H, ß, C(7)H2), C(8)H2) (áõûù-d6) [14] [15] [15] - [16]

ôúðûýÔóóùÙúÔþð? êãß 48 < 6 2003


1010 I, 104, Ûßä. 3.50

Ôó?Õù× Û .

ç 20

1.75

0

0

10

20

30

40

50

60

70 2, ,,

úÛâ. 1. ?ÝâäÒÛßÒÜêÞÈÜÀØ Û ÑÜãâêÜÀØ (ëêã~ÜÒÜÛÒ äã úÛê,ÒÞÈë) âäÒÝêÀ Þfl âãÒÛÜÒÜÛfl IIa.

I, 104, Ûßä. 1.50 ç 10

0.75

0

0

10

20

30

40

50

60

70 2, ,,

úÛâ. 2. ?ÝâäÒÛßÒÜêÞÈÜÀØ Û ÑÜãâêÜÀØ (ëêã~ÜÒÜÛÒ äã úÛê,ÒÞÈë) âäÒÝêÀ Þfl âãÒÛÜÒÜÛfl V.

ßÒÜêÞÈÜã Ñã,,Ò,Òêâfl ã 140Àû. áÞÒÒ ÒÝ^ÛãÜÜë ßââë äÒÒßÒ?Û,ê äÛ 100Àû ã ãÜããÜãâêÛ (ãÝãÞã 5 ßÛÜ) Û ,ÀÞÛ,ê , ,,ãfl~ë ,ãë. ùÇÑëÒêâfl êÒßÜÀØ âê,ã Û ÚÛÝfl âßãÞ. ûßãÞããÇÑÜÀØ ãâêêãÝ ãêÇâÀ,ê, âê,ã ÜÒØêÞÛÑëê ê,ÒÀß ,,ÛãÝÇãÜêãß ÜêÛfl ã äÒÝÒÜÛfl ,ÀäÒÜÛfl ãâÝ, ÝãêãÀØ ãê-

éÛÞÈêã,À,ê, äãßÀ,ê ,ããØ Û ^ÒêãÜãß. × âÞë~Ò â ^ÛÝÞãäÒÜêÜãÜãß ,Àä,?ÛØ ãâãÝ âãÒÚÛê H3PO4. øãâÞÒ äÒÒÝÛâêÞÞÛÑ^ÛÛ ãÇÑã,Þâfl ÝãßäÞÒÝâ II, âãÒÚÛØ ßÒêÜãÞ Û éãâéãÜë ÝÛâÞãêë. øãâÞÒ ãÇÇãêÝÛ ÝãßäÞÒÝâ II 10%-ÜÀß ,ãÜÀß âê,ããß NaOH äãÞë~ÛÞãâÈ âãÒÛÜÒÜÛÒ IIa. ×Àiã âãÒÛÜÒÜÛfl IIa 50%,
ôúðûýÔóóùÙúÔþð? êãß 48 < 6 2003


úæ÷ýÙæ÷ùûýúüôýüú÷ùæ ôÔúýðúù×Ô÷ðæ

1011

ýÇÞÛ^ 2. ôÛâêÞÞã,,éÛ~ÒâÝÛÒ iÝêÒÛâêÛÝÛ, ÒêÞÛ ÒÜê,,ÒÜÛéÝ^ÛãÜÜã,,ã ÝâäÒÛßÒÜê Û ëêã~ÜÒÜÛfl âêëÝêëÀ ?ßäÛÛ~ÒâÝfl éãßëÞ õãÞÒÝëÞflÜÀØ ,Òâ ûÛÜ,,ãÜÛfl øãâêÜâê,ÒÜÜfl ,,ëää a, Õ b, Õ c, Õ , ,, V, Z ,À~ , Å, ,,/âß3 cß-1 Õ3 C7H9NO (I) 123.15 úãßÇÛ~ÒâÝfl Pbca 6.125(2) 15.153(4) 14.477(4) 90 1343.6(7) 8 1.218 0.82 2.69 - 24.97 0h70 k 18 0 l 17 C19H29N2O7P (II) C9H11NO (IIa) C11H15NO (III) C12H17NO (IV) C10H10N2O (V) 428.42 149.19 177.24 191.27 174.20

õãÜãÝÞÛÜÜfl õãÜãÝÞÛÜÜfl õãÜãÝÞÛÜÜfl P21/n 11.181(2) 14.059(6) 13.593(4) 97.78(2) 2117.1(12) 4 1.344 1.73 2.09 - 25.98 -13 h 13 0 k 17 0 l 16 P21/c 7.353(4) 8.176(4) 13.00(1) 105.64(2) 752.6(8) 4 1.313 0.86 3 - 40 0h5 0k6 -9 l 9 P21/n 12.565(6) 5.836(6) 13.007(3) 93.10(3) 952.5(10) 4 1.236 0.79 2.20 - 24.97 -14 h 14 0k6 0 l 15

õãÜãÝÞÛÜÜfl õãÜãÝÞÛÜÜfl P21/n 12.955(3) 6.1595(15) 13.038(3) 95.50(2) 1035.6(4) 4 1.227 0.78 2.12 - 19.99 -12 h 12 0k5 0 l 12 P21/c 5.9870(2) 16.5280(5) 9.5640(3) 111.52(4) 888.71(5) 4 1.304 0.70 3 - 40 -4 h 4 0k7 0l3

ùÇÞâêÈ ë,,Þã, , ,, ùÇÞâêÈ ÛÜÒÝâã, h, k, l

úÑßÒÀ ÝÛâ- 0.32 ç 0.35 ç 0.41 0.31 ç 0.32 ç 0.34 êÞÞ, ßß ùÇÒß ÝâäÒÛßÒÜê ÷ÒÑ,ÛâÛßÀi ãêÚÒÜÛØ ôãÞÛ~Òâê,ã ãêÚÒÜÛØ , õ÷ô/ÝãÞÛ~Òâê,ã ëêã~ÜflÒßÀi äßÒêã, GooF R-éÝêã [I 2(I)] R1/wR2 R-éÝêã äã ,âÒß ãêÚÒÜÛflß R1/wR2 max/min, /Õ3 ?,, âÝÜÛã,ÜÛfl Rwp Rexp Rp Rb 2
ôúðûýÔóóùÙúÔþð? êãß 48 < 6 2003

0.34 ç 0.37 ç 0.49 0.28 ç 0.30 ç 45 1576 1509 1509/174 962 913 913/132

1120 1120 1120/119

4269 4095 4095/379

1.105 0.0755/0.1825 0.1523/0.2209

1.023 0.0644/0.1319 0.1328/0.1622

0.926 0.0754/0.1343 0.2563/0.2091

0.941 0.0569/0.1028 0.1569/0.1404

0.222/- 0.298

0.209/- 0.233 0.02 0.108 0.032 0.076 0.123 7.9

0.212/- 0.209

0.201/- 0.165 0.02 0.058 0.027 0.043 0.077 3.64


1012 ýÇÞÛ^ 3. áÞÛÜÀ â,flÑÒØ d (Õ) , âêëÝêëÒ I û,flÑÈ N(1)-C(6) N(1)-C(2) N(1)-H(1) O(2)-C(2) C(2)-C(3) d 1.3584(8) 1.3684(8) 0.874(5) 1.2534(8) 1.4227(9) û,flÑÈ C(3)-C(4) C(4)-C(5) C(4)-C(8) C(5)-C(6) C(6)-C(7) d

Ôó?Õù× Û . ýÇÞÛ^ 4. ×ÞÒÜêÜÀÒ ë,,ÞÀ (,,) , âêëÝêëÒ I ü,,ãÞ C(6)-N(1)-C(2) C(6)-N(1)-H(1) C(2)-N(1)-H(1) O(2)-C(2)-N(1) O(2)-C(2)-C(3) N(1)-C(2)-C(3) C(4)-C(3)-C(2) 124.55(5) 119.4(3) 116.0(3) 119.58(5) 125.01(6) 115.40(5) 121.18(6) ü,,ãÞ C(3)-C(4)-C(5) C(3)-C(4)-C(8) C(5)-C(4)-C(8) C(6)-C(5)-C(4) C(5)-C(6)-N(1) C(5)-C(6)-C(7) N(1)-C(6)-C(7) 124.55(5) 119.4(3) 116.0(3) 119.58(5) 125.01(6) 115.40(5) 121.18(6)

1.3526(9) 1.3951(9) 1.5215(10) 1.3519(8) 1.4983(9)

ýÇÞÛ^ 5. áÞÛÜÀ â,flÑÒØ d (Õ) , âêëÝêëÒ II û,flÑÈ P(1)-O(11) P(1)-O(14) P(1)-O(13) P(1)-O(12) O(12)-H(12) O(13)-H(13) O(14)-H(14) N(1A)-C(2A) N(1A)-C(9A) d 1.496(2) 1.512(3) 1.542(3) 1.544(3) 0.89(7) 0.94(7) 0.86(8) 1.356(5) 1.359(4) û,flÑÈ N(1A)-H(1A) C(2A)-O(2A) C(2A)-C(3A) C(3A)-C(4A) C(4A)-C(5A) C(4A)-C(10A) C(5A)-C(9A) C(5A)-C(6A) C(7A)-C(8A) 0 1 1 1 1 1 1 1 1 d .89(4) .274(4) .417(5) .370(5) .402(5) .499(5) .358(5) .505(5) .538(6) û,flÑÈ C(8A)-C(9A) N(1B)-C(9B) N(1B)-C(2B) N(1B)-H(1B) C(2B)-O(2B) C(2B)-C(3B) C(3B)-C(4B) C(4B)-C(5B) 1 1 1 0 1 1 1 1 d .481(5) .359(5) .367(5) .88(4) .271(4) .410(5) .366(5) .424(5) û,flÑÈ C(4B)-C(10B) C(5B)-C(9B) C(5B)-C(6B) C(6B)-C(7B) C(7B)-C(8B) C(8B)-C(9B) C(21)-O(21) O(21)-H(21) d 1.479(6) 1.338(5) 1.498(5) 1.524(7) 1.520(7) 1.508(5) 1.387(7) 0.86(5)

ýÇÞÛ^ 6. ×ÞÒÜêÜÀÒ ë,,ÞÀ (,,) , âêëÝêëÒ II ü,,ãÞ O(11)-P(1)-O(14) O(11)-P(1)-O(13) O(14)-P(1)-O(13) O(11)-P(1)-O(12) O(14)-P(1)-O(12) O(13)-P(1)-O(12) P(1)-O(12)-H(12) P(1)-O(13)-H(13) P(1)-O(14)-H(14) C(2A)-N(1A)-C(9A) C(2A)-N(1A)-H(1A) C(9A)-N(1A)-H(1A) O(2A)-C(2A)-N(1A) O(2A)-C(2A)-C(3A) N(1A)-C(2A)-C(3A) C(4A)-C(3A)-C(2A) C(3A)-C(4A)-C(5A) C(3A)-C(4A)-C(10A) C(5A)-C(4A)-C(10A) C(9A)-C(5A)-C(4A) C(9A)-C(5A)-C(6A) C(4A)-C(5A)-C(6A) C(5A)-C(6A)-C(7A) C(6A)-C(7A)-C(8A) 111.85(17) 112.07(16) 109.31(18) 111.53(16) 106.88(18) 104.83(18) 113(4) 119(4) 124(5) 122.8(3) 119(2) 119(2) 119.7(3) 123.5(3) 116.9(3) 121.4(4) 118.6(3) 121.5(4) 119.9(4) 120.0(3) 109.8(3) 130.2(3) 104.4(3) 108.3(4) ü,,ãÞ C(9A)-C(8A)-C(7A) C(5A)-C(9A)-N(1A) C(5A)-C(9A)-C(8A) N(1A)-C(9A)-C(8A) C(9B)-N(1B)-C(2B) C(9B)-N(1B)-H(1B) C(2B)-N(1B)-H(1B) O(2B)-C(2B)-N(1B) O(2B)-C(2B)-C(3B) N(1B)-C(2B)-C(3B) C(4B)-C(3B)-C(2B) C(3B)-C(4B)-C(5B) C(3B)-C(4B)-C(10B) C(5B)-C(4B)-C(10B) C(9B)-C(5B)-C(4B) C(9B)-C(5B)-C(6B) C(4B)-C(5B)-C(6B) C(5B)-C(6B)-C(7B) C(8B)-C(7B)-C(6B) C(9B)-C(8B)-C(7B) C(5B)-C(9B)-N(1B) C(5B)-C(9B)-C(8B) N(1B)-C(9B)-C(8B) C(21)-O(21)-H(21) 102.6(3) 120.3(3) 114.6(3) 125.1(3) 121.6(3) 120(2) 119(2) 117.0(3) 126.6(3) 116.4(3) 123.1(4) 117.2(4) 122.6(4) 120.2(4) 119.5(3) 111.4(4) 129.1(4) 103.4(4) 109.4(4) 102.1(4) 122.2(3) 113.4(3) 124.4(4) 105(3)

ôúðûýÔóóùÙúÔþð? êãß 48 < 6 2003


úæ÷ýÙæ÷ùûýúüôýüú÷ùæ ôÔúýðúù×Ô÷ðæ ýÇÞÛ^ 7. áÞÛÜÀ â,flÑÒØ d (Õ) , âêëÝêëÒ II û,flÑÈ N(1)-C(2) N(1)-C(9) N(1)-H(1) O(2)-C(2) C(2)-C(3) C(3)-C(4) C(4)-C(5) d 1.43(2) 1.37(2) 0.86(7) 1.23(2) 1.41(2) 1.39(2) 1.40(2) û,flÑÈ C(4)-C(10) C(5)-C(6) C(5)-C(9) C(6)-C(7) C(7)-C(8) C(8)-C(9) d 1.51(2) 1.57(3) 1.34(3) 1.53(2) 1.57(2) 1.46(2) ýÇÞÛ^ 8. áÞÛÜÀ â,flÑÒØ d (Õ) , âêëÝêëÒ III û,flÑÈ N(1)-C(2) N(1)-C(11) N(1)-H(1) C(2)-O(2) C(2)-C(3) C(3)-C(4) C(4)-C(5) C(4)-C(12) d 1.352(3) 1.358(3) 0.839(19) 1.264(3) 1.424(3) 1.382(3) 1.392(3) 1.507(4) û,flÑÈ C(5)-C(11) C(5)-C(6) C(6)-C(7) C(7)-C(8) C(8)-C(9) C(9)-C(10) C(10)-C(11) d

1013

1.383(3) 1.513(4) 1.491(4) 1.501(4) 1.563(4) 1.561(4) 1.467(3)

ýÇÞÛ^ 9. ×ÞÒÜêÜÀÒ ë,,ÞÀ (,,) , âêëÝêëÒ III ü,,ãÞ C(2)-N(1)-C(11) C(2)-N(1)-H(1) C(11)-N(1)-H(1) O(2)-C(2)-N(1) O(2)-C(2)-C(3) N(1)-C(2)-C(3) C(4)-C(3)-C(2) C(3)-C(4)-C(5) C(3)-C(4)-C(12) C(5)-C(4)-C(12) C(11)-C(5)-C(4) 124.8(2) 124.6(13) 110.6(13) 121.1(2) 123.0(2) 115.9(2) 120.6(2) 120.6(2) 118.2(2) 121.2(2) 118.4(2) ü,,ãÞ C(11)-C(5)-C(6) C(4)-C(5)-C(6) C(7)-C(6)-C(5) C(6)-C(7)-C(8) C(7)-C(8)-C(9) C(10)-C(9)-C(8) C(11)-C(10)-C(9) N(1)-C(11)-C(5) N(1)-C(11)-C(10) C(5)-C(11)-C(10) 117.5(2) 124.1(2) 117.1(2) 114.8(2) 116.1(2) 113.7(2) 115.1(2) 119.7(2) 115.2(2) 125.1(2)

ýÇÞÛ^ 10. áÞÛÜÀ â,flÑÒØ d (Õ) , âêëÝêëÒ IV û,flÑÈ N(1)-C(2) N(1)-C(12) N(1)-H(1) C(2)-O(2) C(2)-C(3) C(3)-C(4) C(4)-C(5) C(4)-C(13) d 1.361(3) 1.381(3) 0.82(2) 1.273(3) 1.394(4) 1.355(4) 1.425(3) 1.504(4) û,flÑÈ C(5)-C(12) C(5)-C(6) C(6)-C(7) C(7)-C(8) C(8)-C(9) C(9)-C(10) C(10)-C(11) C(11)-C(12) d 1.361(3) 1.527(3) 1.518(3) 1.519(4) 1.550(4) 1.507(3) 1.540(3) 1.478(3)

âãÒÛÜÒÜÛØ III Û IV 20%. ûãÒÛÜÒÜÛÒ V äãÞë~ÒÜã äã ßÒêãÛÝÒ [16]. ÿÝêÒÛâêÛÝÛ äãÞë~ÒÜÜÀi âãÒÛÜÒÜÛØ äÛ,ÒÒÜÀ , êÇÞ. 1. áÞfl ßãÜãÝÛâêÞã, âãÒÛÜÒÜÛØ I, II, III Û IV ÝâäÒÛßÒÜêÞÈÜÀÒ ÛÜêÒÜâÛ,ÜãâêÛ ÛéÝ^ÛãÜÜÀi ãêÚÒÜÛØ äãÞë~ÒÜÀ äÛ ÝãßÜêÜãØ êÒßäÒêëÒ Ü ÛéÝêãßÒêÒ CAD-4 [17] (MoK, ,,éÛêã,ÀØ ßãÜãiãßêã, -âÝÜÛã,ÜÛÒ). øßÒêÀ ÞÒßÒÜêÜãØ fl~ÒØÝÛ ãäÒÒÞflÞÛ Û ëêã~ÜflÞÛ äã 25 ÒéÞÒÝâß , ÛÜêÒ,ÞÒ ë,,Þã, 12-15À. øãâÝãÞÈÝë ÝÛâêÞÞÀ ÛââÞÒã,ÜÜÀi âãÒÛÜÒÜÛØ ÛßÒê ÜÛÑÝÛÒ ÞÛÜÒØÜÀÒ ÝãééÛ^ÛÒÜêÀ äã,,ÞãÒÜÛfl Û ßÞÀÒ ÑßÒÀ, äãä,Ý Ü äã,,ÞãÒÜÛÒ ÜÒ ,,ãÛÞâÈ. øÒ,Û~Üfl ãÇÇãêÝ ßââÛ, ÝâäÒÛßÒÜêÞÈÜÀi ÜÜÀi äã,ãÛÞâÈ äã ÝãßäÞÒÝâë äã,,ßß WinGX98 [18]. ×âÒ äãâÞÒëÛÒ â~ÒêÀ ,ÀäãÞÜflÞÛâÈ , ßÝi ÝãßäÞÒÝâ äã,,ßß SHELX97 [19]. ôÛâêÞÞÛ~ÒâÝÛÒ âêëÝêëÀ ãäÒÒÞÒÜÀ äflßÀßÛ ßÒêãßÛ â äãâÞÒëÛß ëêã~ÜÒÜÛÒß äãÑÛ^ÛãÜÜÀi Û êÒäÞã,Ài äßÒêã, , ÜÛÑãêãäÜãß äÛÇÞÛÚÒÜÛÛ Þfl ,âÒi ÜÒ,ãããÜÀi êãßã,. áÛéÝ^ÛãÜÜÀØ ÝâäÒÛßÒÜê Þfl âãÒÛÜÒÜÛØ IIa Û V, ãâêëäÜÀi êãÞÈÝã , ,ÛÒ äãã?Ýã,, äã,ãÛÞâfl äÛ ÝãßÜêÜãØ êÒßäÒêëÒ Ü ,êãßêÛôúðûýÔóóùÙúÔþð? êãß 48 < 6 2003

ÑÛã,ÜÜãß äãã?Ýã,ãß ÛéÝêãßÒêÒ áúù÷3 (÷øù "ÕëÒ,ÒâêÜÛÝ") ( CuK, Ge-ßãÜãiãßêã) â ?,,ãß 2 0.02À. øßÒêÀ ÞÒßÒÜêÜãØ fl~ÒØÝÛ äãÞë~ÒÜÀ äã äã,,ßßÒ ÛÜÛ^Ûã,ÜÛfl ITO [20]. øãâêÜâê,ÒÜÜÀÒ ,,ëääÀ ãäÒÒÞÒÜÀ äã âÛâêÒßêÛ~ÒâÝÛß äã,,âÜÛflß ãêÚÒÜÛØ. øÒ,ÛêÒÞÈÜfl ÛÜéãß^Ûfl ã âêëÝêëÒ ßãÞÒÝëÞ âãÒÛÜÒÜÛØ IIa Û V äãê,ÒÚÒÜ ÜÜÀßÛ øõú-âäÒÝêãâÝãäÛÛ. ðâiãÜÀÒ ,,ÒãßÒêÛ~ÒâÝÛÒ ßãÒÞÛ äãâêãÒÜÀ äãÞëßäÛÛ~ÒâÝÛßÛ Û ßäÛÛ~ÒâÝÛßÛ ßÒêãßÛ â ÛâäãÞÈÑã,ÜÛÒß äã,,ßß õùúÔû 6.0 [21] Û úûõùDæL [22]. CêëÝêëÀ Ò?ÒÜÀ ßÒêããß "âÛâêÒßêÛ~ÒâÝã,,ã äãÛâÝ" [23] â ÛâäãÞÈÑã,ÜÛÒß ÑÜÜÀi ßãÞÒÝëÞflÜÀi é,,ßÒÜêã,. øãÞÜãäãéÛÞÈÜãÒ ëêã~ÜÒÜÛÒ âêëÝêëÀ äã ßÒêãë úÛê,ÒÞÈ äã,ãÛÞãâÈ äã,,ßßãØ MRIA [24]. × Ý~Òâê,Ò éëÜÝ^ÛÛ äãéÛÞfl ÛâäãÞÈÑã,ÞâÈ äâÒ,ã-×ãØê-éëÜÝ^Ûfl, éãÜ äãÝâÛßÛã,Þâfl äãÞÛÜãßßÛ ?ÒÇÀ?Ò, 5-,,ã äãflÝ. ýÒäÞã,ÀÒ äßÒêÀ ÜÒ,ãããÜÀi êãßã, ßãÞÒÝëÞflÜã,,ã ÝÝâ ,ã ,Òßfl ëêã~ÜÒÜÛfl ëâÒÜflÞÛâÈ. ùâÜã,ÜÀÒ äßÒêÀ ÝâäÒÛßÒÜêã, Û ÝÛâêÞÞã,,éÛ~ÒâÝÛÒ iÝêÒÛâêÛÝÛ âãÒÛÜÒÜÛØ äÛ,ÒÒÜÀ , êÇÞ. 2. õÒÚêãßÜÀÒ ââêãflÜÛfl âÛ-


1014

Ôó?Õù× Û . ýÇÞÛ^ 12. áÞÛÜÀ â,flÑÒØ d (Õ) , âêëÝêëÒ V û,flÑÈ û(1)-C(2) C(1)-C(9) C(2)-O(2) C(2)-C(3) C(3)-C(4) C(3)-C(11) C(4)-C(10) d 1.396(12) 1.346(14) 1.270(13) 1.506(13) 1.463(14) 1.259(12) 1.452(12) û,flÑÈ C(5)-C(6) C(5)-C(10) C(6)-C(7) C(7)-C(8) C(8)-C(9) C(9)-C(10) C(11)-N(11) d 1.485(12) 1.588(15) 1.452(14) 1.623(18) 1.512(13) 1.254(14) 1.207(9)

ýÇÞÛ^ 11. ×ÞÒÜêÜÀÒ ë,,ÞÀ (,,) , âêëÝêëÒ IV ü,,ãÞ C(2)-N(1)-C(12) C(2)-N(1)-H(1) C(12)-N(1)-H(1) O(2)-C(2)-N(1) O(2)-C(2)-C(3) N(1)-C(2)-C(3) C(4)-C(3)-C(2) C(3)-C(4)-C(5) C(3)-C(4)-C(13) C(5)-C(4)-C(13) C(12)-C(5)-C(4) 124.1(2) 119.8(14) 116.0(14) 119.2(2) 124.9(2) 115.9(2) 122.3(2) 120.2(2) 119.1(2) 120.7(2) 118.0(2) ü,,ãÞ C(12)-C(5)-C(6) C(4)-C(5)-C(6) C(7)-C(6)-C(5) C(8)-C(7)-C(6) C(7)-C(8)-C(9) C(10)-C(9)-C(8) C(9)-C(10)-C(11) C(12)-C(11)-C(10) C(5)-C(12)-N(1) C(5)-C(12)-C(11) N(1)-C(12)-C(11) 120.7(2) 121.2(2) 114.8(2) 117.8(2) 114.7(2) 115.8(2) 115.2(2) 112.2(2) 119.6(2) 125.8(2) 114.6(2)

ýÇÞÛ^ 13. øßÒêÀ ßÒÚêãßÜÀi ÝãÜêÝêã, , ÛââÞÒã,ÜÜÀi âêëÝêëi D-H N(1)-H(1) N(1A)-H(1A) N(1B)-H(1B) O(12)-H(12) O(13)-H(13) O(14)-H(14) O(21)-H(21) N(1)-H(1) N(1)-H(1) N(1)-H(1) N(1)-H(1) d(D-H) 0.874(1) 0.89(4) 0.88(4) 0.89(7) 0.94(6) 0.86(8) 0.86(5) 0.86(7) 0.839(19) 0.82(2) 0.89(5) d(DÇÇÇA) 2.768(1) 2.780(4) 2.768(4) 2.548(4) 2.589(4) 2.462(4) 2.710(4) 2.81(1) 2.785(3) 2.776(3) 2.71(1) d(HÇÇÇA) I 1.895(5) II 1.89(4) 1.89(4) 1.68(7) 1.65(6) 1.60(8) 1.86(5) IIa 2.01(7) III 1.96(2) IV 1.96(2) V 1.83(5) DHA 176.1(1) 177(4) 173(4) 168(7) 173(6) 175(8) 173(5) 156(7) 167(2) 174(2) 171(6) A O(2) O(11) O(21) O(2A) O(11) O(2B) O(2A) O(2) O(2) O(2) O(2) (ãäÒ^Ûfl âÛßßÒêÛÛ) (- x; 1 - y; 1 - z)

(- x; 1 - y; 1 - z) (- x; 1 - y; 1 - z) (1 - x; 1 - y; 1 - z) (1 - x; y - 1/2; 1/2 - z) (- x; - y; 1 - z) (1 - x; - y; 1 - z) (-1 - x; 1 - y; - z)

øÛßÒ~ÜÛÒ. D - êãß-ãÜã; A - êãß-Ý^Òäêã; H - êãß ,ããã; ââêãflÜÛfl d, Õ; ë,,ãÞ , ,,.

âêÒßêÛÑÛã,ÜÀ , êÇÞ. 3-12. ?ÝâäÒÛßÒÜêÞÈÜÀÒ ÒÜê,,ÒÜã,âÝÛÒ Û ÑÜãâêÜÀÒ âäÒÝêÀ äÒâê,ÞÒÜÀ Ü Ûâ. 1 Û 2. øãâêÜâê,ÒÜÜãÒ âäãÞãÚÒÜÛÒ êãßã, , ßãÞÒÝëÞi Û Ûi ÜëßÒ^Ûfl äãÝÑÜÀ Ü Ûâ. 3-8, äãÞë~ÒÜÜÀi â ÛâäãÞÈÑã,ÜÛÒß ,,éÛ~ÒâÝã,,ã äÝÒê äã,,ßß PLUTON96 [25]. ôÛâêÞÞã,,éÛ~ÒâÝfl ÛÜéãß^Ûfl äã ÛââÞÒã,ÜÜÀß âãÒÛÜÒÜÛflß ÒäãÜÛã,Ü , ôÒßÇÛÚâÝãØ ÇÑÒ âêëÝêëÜÀi ÜÜÀi (ÒäãÜÒÜêÀ < 000001-000005).

úæñüó?ýÔý? ð ðÿ ùÕûüìáæ÷ðæ ùÇÒÛÑ,ÒâêÜã, ~êã äÛÛãÜÀ-2 Û Ûi âãÞÛ fl,Þflêâfl ßÇÛÒÜêÜÀßÛ âãÒÛÜÒÜÛflßÛ , ÒÝ^Ûfli â ÞÒÝêãéÛÞßÛ, ÜäÛßÒ, , ÒÝ^Ûfli ÞÝÛÞÛã,ÜÛfl. ÷ÞÛ~ÛÒ ßÒêÛÞÈÜãØ ,,ëääÀ ÛÞÛ ßÒêÛÞÒÜã,ã,,ã Ñ,ÒÜ , äãÞãÚÒÜÛÛ 6 äÛÛãÜ-2 âäãâãÇÜã âëÒâê,ÒÜÜã äã,ÞÛflêÈ Ü âÒÞÒÝêÛ,ÜãâêÈ êÝÛi ÒÝ^ÛØ Ñ â~Òê âêÒÛ~ÒâÝã,,ã ÝÜÛã,ÜÛfl ÞÝÛÞÈÜÀß é,,ßÒÜêãß êãß Ñãê. × êãØ â,flÑÛ äÒâê,ÞflÞã ÛÜêÒÒâ ,ÀflâÜÛêÈ, ÜâÝãÞÈÝã ,ÒÞÛÝ âêÒäÒÜÈ êÝã,,ã ÝÜÛã,ÜÛfl äÛ ÑßÒÜÒ ßÒôúðûýÔóóùÙúÔþð? êãß 48 < 6 2003


úæ÷ýÙæ÷ùûýúüôýüú÷ùæ ôÔúýðúù×Ô÷ðæ

1015

C(8)

C(4) C(5) C(6) C(7) C(3) C(2) N(1) H(1) O(2)

êÛÞÈÜãØ ,,ëääÀ Ü ^ÛÝÞãÞÝÜã,ÀØ é,,ßÒÜê ÑÞÛ~Üã,,ã ÑßÒ, ÜÜÒÞÛã,ÜÜÀØ äã â,flÑÛ û(5)-û(6). ûêëÝêëÜÀÒ ÜÜÀÒ Þfl âãÒÛÜÒÜÛfl â ^ÛÝÞã,,ÒÝâÜã,Àß é,,ßÒÜêãß (2-ãÝâã1,2,5,6,7,8-,,ÒÝâ,,ÛãiÛÜãÞÛÜ (VI)) äãÞë~ÒÜÀ ÜÒÒ [11]. CêëÝêëë ^ÛÜäãÛÑ,ãÜã,,ã V â,ÜÛ,ÞÛ â ÒÒ äãêãêÛäãß - 6-ßÒêÛÞ-3-^ÛÜäÛÛãÜãß-2 (VII), ãäÛâÜÜÀß , [26]. øãâêÒØ?Ûß âäãâãÇãß âãäãâê,ÛêÈ âêëÝêëÜÀÒ ÛÑßÒÜÒÜÛfl äÛ äÒÒiãÒ ãê ßÒêÛÞÈÜãØ ,,ëääÀ Ý ^ÛÝÞãÞÝÜã,ãßë é,,ßÒÜêë , ßãÞÒÝëÞi IVII fl,ÞflÒêâfl âëäÒäãÑÛ^Ûfl âêëÝêëÀ äÛÛãÜã,ã,,ã ßãÞÒÝëÞÀ äãêãêÛä I â äÛÛãÜã,ÀßÛ é,,ßÒÜêßÛ ë,,Ûi äãÛÑ,ãÜÀi II-V Û âãäãâê,ÞÒÜÛÒ ,ÑÛßÜã,,ã âäãÞãÚÒÜÛfl 6-û÷3-,,ëääÀ Û ßÒêÛÞÒÜã,Ài Ñ,ÒÜÈÒ, , äãÞãÚÒÜÛÛ 6 (Ûâ. 9). ôÝ ,ÛÜã, ÞÛ?È , âÞë~Ò ^ÛÝÞãäÒÜêÜã,ã,,ã äãÛÑ,ãÜã,,ã IIa êÝãÒ ÝÜÛã,ÜÛÒ ßÒÜÈ?Ò (âêÒÛ~ÒâÝãÒ ÜäflÚÒÜÛÒ "âêfl,,Û,Òê" äflêÛ~ÞÒÜÜÀØ ^ÛÝÞ, ãêÞflfl ßÒêÛÞÒÜã,ãÒ Ñ,ÒÜã , äãÞãÚÒÜÛÛ 6 ãê êãß Ñãê, Ûâ. 9). ×ã ,âÒi ãâêÞÈÜÀi âÞë~fli (Ûâ. 9Ç) âäãÞãÚÒÜÛÒ ßÒêÛÞÒÜã,ã,,ã Ñ,ÒÜ ?ÒâêÛ-, âÒßÛ- Û ,ãâÈßÛ~ÞÒÜÜã,,ã ^ÛÝÞã, äÝêÛ~ÒâÝÛ êã~Üã âã,äÒê â âäãÞãÚÒÜÛÒß ßÒêÛÞÈÜãØ ,,ëääÀ , ããÜ~ÞÈÜãØ ßãÞÒÝëÞÒ I. ÔÜÞã,,Û~Üfl ÝêÛÜ ÜÇÞÒêâfl äÛ äÒÒiãÒ ãê ßÒêÛÞÈÜã,,ã Ý ^ÛÝÞã,,ÒÝâÜã,ãßë äãÛÑ,ãÜãßë , 3^ÛÜäÛÛãÜi V, VII (Ûâ. 9,). ×âÒ ÇÒÑ ÛâÝÞ~ÒÜÛfl âãÒÛÜÒÜÛfl (I-V) ãÇÑëê âÛâêÒßÀ ÷-â,flÑÒØ, ÝãêãÀÒ fl,Þflêâfl ÜÒãê-

úÛâ. 3. ûêãÒÜÛÒ ßãÞÒÝëÞÀ, ÜëßÒ^Ûfl êãßã, Û ãÇÑã,ÜÛÒ ,ãããÜÀi â,flÑÒØ Þfl âãÒÛÜÒÜÛfl I.

H(21) C(10A) C(3A) C(4A) C(5A) C(6A) C(9A) O(11) C(7A) C(8A) C(2A) O(2A) N(1A) H(1A) P(1) H(14) H(13) O(14) O(13) H(12) O(12)

C(10B) C(6B) C(7B) C(5B) C(4B) C(8B) C(3B) C(2B) H(1B) O(2B) C(9B) N(1B)

O(21) C(21) H(21)

O(2A)

úÛâ. 4. ûêãÒÜÛÒ ßãÞÒÝëÞÀ, ÜëßÒ^Ûfl êãßã, Û ãÇÑã,ÜÛÒ ,ãããÜÀi â,flÑÒØ Þfl âãÒÛÜÒÜÛfl II. ôúðûýÔóóùÙúÔþð? êãß 48 < 6 2003


1016

Ôó?Õù× Û .

C(12) C(7) C(6) C(8) O(2) H(1) C(2) N(1) C(9) C(11) C(2) N(1) C(10) H(1) O(2) C(4) C(5)

C(3)

C(3)

C(9) C(8) C(7)

C(4) C(5) C(6)

C(10)

úÛâ. 5. ûêãÒÜÛÒ ßãÞÒÝëÞÀ, ÜëßÒ^Ûfl êãßã, Û ãÇÑã,ÜÛÒ ,ãããÜÀi â,flÑÒØ Þfl âãÒÛÜÒÜÛfl IIa.

úÛâ. 6. ûêãÒÜÛÒ ßãÞÒÝëÞÀ, ÜëßÒ^Ûfl êãßã, Û ãÇÑã,ÜÛÒ ,ãããÜÀi â,flÑÒØ Þfl âãÒÛÜÒÜÛfl III.

N(11) C(5) C(6) C(13) C(5) C(6) C(7) C(8) C(9) C(3) C(4) O(2) C(2) H(1) C(7) C(4) C(10) C(9) C(8) C(3) C(11)

N(1) C(12) C(11) C(10)

C(2) N(1) H(1)

O(2)

úÛâ. 7. ûêãÒÜÛÒ ßãÞÒÝëÞÀ, ÜëßÒ^Ûfl êãßã, Û ãÇÑã,ÜÛÒ ,ãããÜÀi â,flÑÒØ Þfl âãÒÛÜÒÜÛfl IV.

úÛâ. 8. ûêãÒÜÛÒ ßãÞÒÝëÞÀ, ÜëßÒ^Ûfl êãßã, Û ãÇÑã,ÜÛÒ ,ãããÜÀi â,flÑÒØ Þfl âãÒÛÜÒÜÛfl V.

ÒßÞÒßÀß êÛÇëêãß ÝÛâêÞÞÛ~ÒâÝÛi âêëÝêë êã,,ã ÝÞââ ,ÒÒâê,. ýÝ, âãÒÛÜÒÜÛfl I, III-V ãÇÑëê ^ÒÜêãâÛßßÒêÛ~ÜÀÒ ,ãâÈßÛ~ÞÒÜÜÀÒ ÛßÒÀ â ë~âêÛÒß êãßã, H(1)N(1)C(2)O(2) äÛÛãÜã,ã,,ã ^ÛÝÞ (êÇÞ. 13, Ûâ. 3, 6-8). ðâÝÞ~ÒÜÛÒß ÛÑ ä,ÛÞ ãÇÑã,ÜÛfl ,ãâÈßÛ~ÞÒÜÜÀi ^ÛÝÞÛ~ÒâÝÛi ÛßÒã, fl,ÞflÒêâfl ßãÞÒÝëÞ II. × ãÇÑã,ÜÛÛ ÷-â,flÑÒØ êã,,ã âãÒÛÜÒÜÛfl

ë~âê,ëê êÒ ÚÒ êãßÀ - H(1), N(1) Û O(2) äÛÛãÜ, Üã iÝêÒ â,flÑÀ,ÜÛfl ë,,ãØ - , ÝÛâêÞÞÛ~ÒâÝãØ âêëÝêëÒ ,ßÒâêã ÛßÒÜÀi ãÇÑã,ÜÛØ äãfl,Þflêâfl ÇÒâÝãÜÒ~ÜÀÒ ^ÒäÛ (Ûâ. 5). ÕãÞÒÒ Ñ,Òê,ÞÒÜÜãØ âÛâêÒßãØ ÷-â,flÑÒØ ãÇÞÒê âãÒÛÜÒÜÛÒ II, ,,Ò , Ûi ãÇÑã,ÜÛÛ ë~âê,ëê ÜÒ êãÞÈÝã ,,ÒêÒã^ÛÝÞÛ~ÒâÝÛÒ ßãÞÒÝëÞÀ, Üã Û ßãÞÒÝëÞÀ ãêãéãâéãÜãØ ÝÛâÞãêÀ Û âãÞÈ,êÜãØ ßãÞÒÝëÞÀ
ôúðûýÔóóùÙúÔþð? êãß 48 < 6 2003


úæ÷ýÙæ÷ùûýúüôýüú÷ùæ ôÔúýðúù×Ô÷ðæ

1017

(a) C(4) C(5) C(3)

C(2) C(6) N(1) O(2) H(1)

(Ç) C(4) C(5) C(3)

C(2) C(6) N(1) O(2) H(1) (,) C(5) C(4) C(3)

C(2) C(6) N(1) O(2) H(1)

úÛâ. 9. ûëäÒäãÑÛ^Ûfl ßãÞÒÝëÞ: - I Û IIa, Ç - I Û IV, , - VII Û V. ôúðûýÔóóùÙúÔþð? êãß 48 < 6 2003


1018

Ôó?Õù× Û . 9. úÀÇÝã, ×.Õ., ÕÇÒ, æ.×., øâÛ~ÜÛ~ÒÜÝã ô.?. // ôÛâêÞÞã,,éÛfl. 2002. ý. 47. < 4. û. 678. 10. úÀÇÝã, ×.Õ., ÕÇÒ, æ.×., åÛâÒ,Û~ Ô.Ô. Û . // ôÛâêÞÞã,,éÛfl. 2002. ý. 47. < 6. û. 1042. 11. ÔÞÈÇã, á.×., úÀÇÝã, ×.Õ., ÕÇÒ, æ.×., ÔâÞÜã, ó.Ô. // ôÛâêÞÞã,,éÛfl. 2003. ý. 48. < 2. û. 277. 12. úÀÇÝã, ×.Õ., ÕãÇã?Ýã ó.Ù., ÕëÝã, ÷.ð. Û . // ôÛâêÞÞã,,éÛfl. 2003. ý. 48. < 3. û. (, äÒ~êÛ) 13. Allen F.H., Kennard O. // Chem. Des. Automat. News. 1993. V. 8. < 1. P. 31. 14. Bardhan G. // J. Chem. Soc. 1929. P. 2231. 15. Kato T., Sato M., Noda M., Itoh T. // Chem. Pharm. Bull. 1980. V. 28. P. 2244. 16. Paine J.B. // J. Heterocycl. Chem.. 1987. V. 24. P. 351. 17. Enraf-Nonius CAD-4 Software. Version 5.0. EnrafNonius, Delft, Netherlands, 1989. 18. Farrugia L.J. WinGX98. X-Ray Crystallographic Programs for Windows. University of Glasgow, U.K., 1998. 19. Sheldrick G.M. SHELX97. Program for the Solution and Refinement of Crystal Structures. University of G?ttingen, Germany, 1997. 20. Visser J.W. // J. Appl. Cryst. 1969. V. 2. P. 89. 21. Stewart J.J.P. MOPAC 6.0. QCPE Program < 455. Department of Chemistry. Bloomington: Indiana University. USA, 1990. 22. PCMODEL 7.0. Molecular Modelling Software for the Windows 95/NT. Sarena Software. Bloomington. USA, 1999. 23. Chernyshev V.V., Schenk H. // Z. Kristallogr. 1998. B. 213. S. 1. 24. Zlokazov V.B., Chernyshev V.V. // J. Appl. Cryst. 1992. V. 25. P. 447. 25. Spek A.L. PLUTON96. Molecular Graphics Program. University of Utrecht, Netherlands, 1996. 26. Munakata M., Wu Liang Ping, Yamamoto M. et al. // J.Am. Chem. Soc. 1996. V. 118. P. 3117. 27. Nardelli M. // J. Appl. Cryst. 1995. V. 28. P. 259.

ßÒêÜãÞ. ôÝ ,ÛÜã ÛÑ Ûâ. 4, êãÞÈÝã ßãÞÒÝëÞÀ ÷3úù4 ãÇÑëê ÷-â,flÑflßÛ ÛßÒÜÀØ é,,ßÒÜê ÝÛâêÞÞÛ~ÒâÝãØ âêëÝêëÀ. ÿÝêÒ ÷-â,flÑÒØ 2 ÝÛâêÞÞã,,éÛ~ÒâÝÛ ÜÒÑ,ÛâÛßÀi äÛÛãÜã,Ài ßãÞÒÝëÞ (Ô Û ×) ÑÞÛ~ÒÜ. ýÝ, ßãÞÒÝëÞ Ô ãÇÑëÒê êÛ ÷-â,flÑÛ - ,Ò â ÷3úù4 Û ãÜë â ßãÞÒÝëÞãØ ßÒêÜãÞ, ßãÞÒÝëÞ × - êãÞÈÝã ,Ò ÷-â,flÑÛ - ãÜë â ÷3úù4 Û ãÜë â ßãÞÒÝëÞãØ ßÒêÜãÞ, äÛ~Òß âãÞÈ,êÜfl ßãÞÒÝëÞ ,ÀâêëäÒê , ,ëi Ûäãâêâfli - Û ãÜã, Û Ý^Òäêã (êÇÞ. 13). úâ~ÒêÀ äßÒêã, ÷-â,flÑÒØ äã,ÒÒÜÀ â ÛâäãÞÈÑã,ÜÛÒß äã,,ßßÀ PARST95 [27] Ô,êãÀ ,ÀÚê ÇÞ,,ãÜãâêÈ úãââÛØâÝãßë éãÜë éëÜßÒÜêÞÈÜÀi ÛââÞÒã,ÜÛØ Ñ éÛÜÜâã,ë äãÒÚÝë , ãäÞêÒ ÞÛ^ÒÜÑÛÛ Ü äãÞÈÑã,ÜÛÒ ôÒßÇÛÚâÝÛß ÇÜÝãß âêëÝêëÜÀi ÜÜÀi (,,Üê < 02-07-90322), êÝÚÒ éãÜë ð÷ýÔû (,,Üê INTAS 00-0711). ûøðûùô óðýæúÔýüú?
1. úÀÇÝã, ×.Õ., ìëÝã, û.Ù., ÕÇÒ, æ.×. Û . // ôÛâêÞÞã,,éÛfl. 1999. ý. 44. < 6. û. 1067. 2. úÀÇÝã, ×.Õ., ìëÝã, û.Ù., ÕÇÒ, æ.×. Û . // ôÛâêÞÞã,,éÛfl. 2000. ý. 45. < 1. û. 108. 3. úÀÇÝã, ×.Õ., ìëÝã, û.Ù., ÕÇÒ, æ.×. Û . // ôÛâêÞÞã,,éÛfl. 2000. ý. 45. < 2. û. 292. 4. úÀÇÝã, ×.Õ., ìëÝã, û.Ù., øâÛ~ÜÛ~ÒÜÝã ô.?., ÕÇÒ, æ.×. // ôããÛÜ^. iÛßÛfl. 2000. ý. 26. < 9. û. 714. 5. úÀÇÝã, ×.Õ., ìëÝã, û.Ù., ÕÇÒ, æ.×., ñãÜÜÒ,ÒÞÈ ?. // ôÛâêÞÞã,,éÛfl. 2001. ý. 46. < 3. û. 435. 6. úÀÇÝã, ×.Õ., ýãflÜã, û.ð., ÕÇÒ, æ.×. Û . // ôÛâêÞÞã,,éÛfl. 2001. ý. 46. < 5. û. 1069. 7. úÀÇÝã, ×.Õ., ÕÇÒ, æ.×, øâÛ~ÜÛ~ÒÜÝã ô.?., ñãÜÜÒ,ÒÞÈ ?. // ôÛâêÞÞã,,éÛfl. 2002. ý. 47. < 1. û. 76. 8. úÀÇÝã, ×.Õ., ÕÇÒ, æ.×., ?ÒÜÀ?Ò, ×.×. // ôÛâêÞÞã,,éÛfl. 2002. ý. 47. < 3. û. 473.

ôúðûýÔóóùÙúÔþð? êãß 48 < 6 2003