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Moscow University Chemistry Bulletin Vol. 43, No. 6, P. 399 (2002)
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Kalmukova Ye. N., Yermolaeva T. N., Yeriomin S. A.

Development of Quartz Crystal Microbalance Immunosensors for the Flow Injection Analysis of High- and Low-Molecular Weight Compounds

Abstract

Possibility of application of piezo-quartz resonators with the silver electrodes for home-made immunosensors to flow injection analysis of high- and low-molecular weight compounds was estimated. It was shown that high molecular weight compounds could be directly detected by increasing of sensor’s mass in the results of formation of immunocomplexes. The liner change of frequency of biosensor from concentration of anti Rubella DNA antibody was in range 0.1-25 μg/mL. The low molecular weight haptens like cotinine (metabolite of nicotine) could be also detected by developed immunosensor, but only by competitive method. It was found, that concentration of cotinine in urea for smokers and non-smokers are 4-6 and 0.5-0.7 mg/L, respectively.
Moscow University Chemistry Bulletin.
2002, Vol. 43, No. 6, P. 399
   

Copyright (C) Chemistry Dept., Moscow State University, 2002
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