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Proskurnin M. A., Orlova N. V., Pikhtar' A. V., Kuznetsova V. V.
Determination of
p-Aminophenol in Paracetamol by Reaction with Resorcinol Using Thermal Lens
Spectrometry
Abstract
The conditions for
photometric determination of p-aminophenol by its reaction with resorcinol in
alkaline solutions were found. The limit of detection is 2 mg/mL. Thermal lensing under these conditions provided the limit of detection
of 0.1 mg/mL; thus, a 20-fold increase in the sensitivity was attained. The
achieved limit of detection is fivefold lower than the value for the standard
procedure for the determination of p-aminophenol with sodium nitroprusside. The
procedure was verified by determining p-aminophenol in samples of paracetamol
produced by several pharmaceutical companies.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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