Application of multipotent mesenchymal stromal cells from human adipose tissue for compensation of neurological deficiency induced by 3-nitropropionic Acid in rats.

Kulikov AV; Stepanova MS; Stvolinsky SL; Hudoerkov RM; Voronkov DN; Rzhaninova AA; Goldstein DV; Boldyrev AA

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Article

Title:	Application of multipotent mesenchymal stromal cells from human adipose tissue for compensation of neurological deficiency induced by 3-nitropropionic Acid in rats.
Authors:	Kulikov AV; Stepanova MS; Stvolinsky SL; Hudoerkov RM; Voronkov DN; Rzhaninova AA; Goldstein DV; Boldyrev AA
Publication:	Bull Exp Biol Med. 2008 Apr;145(4):514-9.
PubmedID	19110607
Abstract
We evaluated possible therapeutic effect of multipotent mesenchymal stromal cells from human adipose tissue differentiated to neuronal phenotype with retinoic acid on Wistar rats subjected to toxic effect of 3-nitropropionic acid. Transplantation of mesenchymal stromal cells from human adipose tissue considerably decreased neurological symptoms, normalized exploratory activity (open field test) and long-term memory (Morris test), which correlated with normalization of pathomorphological manifestations in the brain. Destructive changes in the caudate nucleus caused by treatment with 3-nitropropionic acid (reduced size of neurons, changes in their shape, and cell edema) tended to decrease under the effect of multipotent mesenchymal stromal cells: the area of neurons increased 2-fold, the cells acquired typical round shape, cell edema decreased.