An in-depth discussion of molecular electronics in an easy-to-understand manner, designed for chemists, computer scientists, surface scientists, physicists and applied mathematicians. Lighter overviews are provided for the science-minded layperson and the high-tech entrepreneur in this nanoscale science. The author has included a detailed synthetic chemistry treasure chest, protocols of self-assembling routes for bottom-up fabrication atop silicon platforms, representative current-voltage and memory readouts from molecular devices, and overviews of present architectural and mathematical approaches to programming molecular computing machines. The investment and commercial insertion landscape is painted along with a "Who's Who" in the molecular electronics business space. Advice and forewarnings are provided for the aspiring academic corporate founder and the business CEO seeking to establish a high-tech company while wading through the idiosyncratic morass of university personalities and university-owned intellectual property.