Документ взят из кэша поисковой машины. Адрес оригинального документа : http://kodomo.cmm.msu.ru/~dracon/t4-files/Alignment/alig_full.msf Дата изменения: Wed May 24 10:39:09 2006 Дата индексирования: Sat Dec 22 07:05:25 2007 Кодировка:

PileUp

GDC ******** GeneDoc Multiple Sequence Alignment Editor ********
GDC 01144b0190000cffffffffffff000000000000000000808080c0c0c0ffff
GDC ff000000000000f43f000000000000f43f000000000000f03f0000000000
GDC 00f03f00A000300000190000cA54696d6573204e657720526f6d616e00B0
GDC 0320002000000000000000000000601444e000245510003535400044b520
GDC 00546595700064c49564d00285037343437375f53594e59332c0d0a434c4
GDC 3415f45434f4c492c0d0a5037333734355f53594e59332c0d0a593330355
GDC f4d45544a412c0d0a4f32383835375f41524346552c0d0a5039363832305
GDC f4d594354552c0d0a4f35373734375f505952484f2c0d0a4f39343238375
GDC f534348504f2c0d0a5132323833335f434145454c2c0d0a5131383336385
GDC f434145454c2c0d0a434c434b415f48554d414e2c0d0a434c434e325f485
GDC 54d414e2c0d0a434943485f544f524d412c0d0a434c434e315f5241542c0
GDC d0a434c43445f41524154482c0d0a434c43415f41524154482c0d0a50393
GDC 33536375f534f4c54552c0d0a5139424842325f434145454c2c0d0a434c4
GDC 34e365f48554d414e2c0d0a434c434e375f5241542c0d0a4f36303935385
GDC f4c45494d412c0d0a4f36303135395f534348504f2c0d0a474546315f594
GDC 54153542c0d0a5131373830345f434145454c2c0d0a434c434e335f52415
GDC 42c0d0a4f31333038305f58454e4c412c0d0a416c69676e6d656e742c0d0
GDC a446f6d61696e2c0d0a5365636f6e646172792c0d0a46756e6374696f6e6
GDC 16c4141293b0d0a00BBAABAAA0000002a000a00020001B20AAA000a203a2
GDC 000203a200000000000000059400000000000000000000c5058000000fff
GDC f000047580000ff00ff000041475358000000ffffff0056434147444e535
GDC 450580000ff00ffff00484b525800ff00000000ff4544580000ff000000f
GDC f484b5245445800ffffff0000ff48524551444e425a5800ff000000ff005
GDC 957484b524551444e5354425a580000000000ff00494c56415800ff00008
GDC 080804659574858000000ff808080494c564341474d4659574854505800f
GDC fffff0000000c50580000000000000047580000000000000041434753580
GDC 0000000000000564147444e5354505800000000000000484b52580000000
GDC 000000045445800000000000000484b52454458000000000000004852455
GDC 1444e425a5800000000000000435957484b524551444e5354425a5800000
GDC 000000000494c56415800000000000000465957485800000000000000494
GDC c564341474d46595748545058000000000000000300ffffff00000000fff
GDC fff80808000000000c0c0c00000ABBBBBBBBBBBBBB00ff00A001e0001000
GDC 100010001000100010001000100010001000100010001000100010001000
GDC 10001000100010001000100010001000100010001000100010001A0018AA
GDC 000000000000000000000003A00ff00A0000000000805640000000000080
GDC 514000000000000049400000020000000000001440A0000000098b20c410
GDC 00000001025064100000000189806410000000078b10b4100AAABB000053
GDC 74616e646172640046464c4c5353535359592a2a43432a574c4c4c4c5050
GDC 505048485151525252524949494d545454544e4e4b4b5353525256565656
GDC 414141414444454547474747002d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d
GDC 2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d4d2d2d2d2d2d2d2d2d2d2d2d
GDC 2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d00BBBBB000000000000001e000
GDC 2000002ef00000000ff00000000fd00000000ff000002000002ef0000000
GDC 0ff00000000fd00000000ff000002000002ef00000000ff00000000fd000
GDC 00000ff000002000002ef00000000ff00000000fd00000000ff000002000
GDC 002ef00000000ff00000000fd00000000ff000002000002ef00000000ff0
GDC 0000000fd00000000ff000002000002ef00000000ff00000000fd0000000
GDC 0ff000002000002ef00000000ff00000000fd00000000ff000002000002e
GDC f00000000ff00000000fd00000000ff000002000002ef00000000ff00000
GDC 000fd00000000ff000002000002ef00000000ff00000000fd00000000ff0
GDC 00002000002ef00000000ff00000000fd00000000ff000002000002ef000
GDC 00000ff00000000fd00000000ff000002000002ef00000000ff00000000f
GDC d00000000ff000002000002ef00000000ff00000000fd00000000ff00000
GDC 2000002ef00000000ff00000000fd00000000ff000002000002ef0000000
GDC 0ff00000000fd00000000ff000002000002ef00000000ff00000000fd000
GDC 00000ff00000300000144000000ffffff000002ef00000000ff00000000f
GDC d00000000ff000002000002ef00000000ff00000000fd00000000ff00000
GDC 2000002ef00000000ff00000000fd00000000ff000002000002ef0000000
GDC 0ff00000000fd00000000ff000002000002ef00000000ff00000000fd000
GDC 00000ff000002000002ef00000000ff00000000fd00000000ff000002000
GDC 002ef00000000ff00000000fd00000000ff000003000002ef00000000ff0
GDC 0000000fe000000ffffff000000fd00000000ff000000000000000046000
GDC 0011e000000ff80000000011d000000ff80000000011c000000ff8000000
GDC 0011b000000ff80000000011a000000ff800000000119000000ff8000000
GDC 00118000000ff800000000117000000ff800000000116000000ff8000000
GDC 00115000000ff800000000114000000ff800000000113000000ff8000000
GDC 00112000000ff800000000111000000ff800000000110000000ff8000000
GDC 0013f000000ff80000000013e000000ff80000000013d000000ff8000000
GDC 0013c000000ff800000000149000000ff800000000148000000ff8000000
GDC 00147000000ff800000000146000000ff800000000145000000ff8000000
GDC 00144000000ff800000000143000000ff800000000142000000ff8000000
GDC 00141000000ff800000000140000000ff800000000288000000ff8000000
GDC 00287000000ff800000000286000000ff800000000285000000ff8000000
GDC 00284000000ff800000000282000000ff8000000001760000008000ff000
GDC 001770000008000ff000001780000008000ff000001790000008000ff000
GDC 0017a0000008000ff0000017b0000008000ff0000017c0000008000ff000
GDC 0017d0000008000ff0000017e0000008000ff0000017f0000008000ff000
GDC 00283000000ff804000000289000000ff80400000028f000000ff8040000
GDC 0028e000000ff80400000028d000000ff80400000028c000000ff8040000
GDC 0028b000000ff80400000028a000000ff8040000001800000008000ff000
GDC 001860000008000ff000001870000008000ff000001810000008000ff000
GDC 001820000008000ff000001830000008000ff000001840000008000ff000
GDC 001850000008000ff0000018b0000008000ff0000018a0000008000ff000
GDC 001890000008000ff000001880000008000ff00000291000000ff8040000
GDC 00290000000ff80400000010f000000ff80000000010e000000ff8000000
GDC 0010d000000ff80000003000000000000BBAB001e0000000000000000000
GDC 000000000000000000000000000000000000000000201b7B000000000000
GDC 564000000000008051400000000000804a4000DAAB000000ffffff030201
GDC 4445484b524e5153540000ff00ff0000024c49564d4659574147435000ff
GDC 000000ff0004014445484b520000ff00ff0000024e5153540000ff00ff80
GDC 00034c49564d46595700ff000000ff0004414700ff000000800008014445
GDC 0000ff00ff000002484b5200ffffffff0000034e510000ff00ff80000453
GDC 5400ffffffff8000054c495600ff000000ff000646595700ffffff00ff00
GDC 07414700ff0000008000084d4300ffffff0080000000000000Affffff808
GDC 08000A
alig_full.msf MSF: 1276 Type: P May 24, 2006 10:39 Check: 9650 ..

Name: CICH_TORMA Len: 1276 Check: 7081 Weight: 0.05
Name: CLCA_ARATH Len: 1276 Check: 6838 Weight: 0.04
Name: CLCA_ECOLI Len: 1276 Check: 8340 Weight: 0.04
Name: CLCD_ARATH Len: 1276 Check: 3306 Weight: 0.06
Name: CLCKA_HUMAN Len: 1276 Check: 8511 Weight: 0.03
Name: CLCN1_RAT Len: 1276 Check: 6134 Weight: 0.03
Name: CLCN2_HUMAN Len: 1276 Check: 2251 Weight: 0.03
Name: CLCN3_RAT Len: 1276 Check: 8605 Weight: 0.03
Name: CLCN6_HUMAN Len: 1276 Check: 945 Weight: 0.02
Name: CLCN7_RAT Len: 1276 Check: 4275 Weight: 0.02
Name: GEF1_YEAST Len: 1276 Check: 6771 Weight: 0.03
Name: O13080_XENLA Len: 1276 Check: 6967 Weight: 0.04
Name: O28857_ARCFU Len: 1276 Check: 5302 Weight: 0.05
Name: O57747_PYRHO Len: 1276 Check: 2467 Weight: 0.03
Name: O60159_SCHPO Len: 1276 Check: 2171 Weight: 0.03
Name: O60958_LEIMA Len: 1276 Check: 1477 Weight: 0.03
Name: O94287_SCHPO Len: 1276 Check: 8809 Weight: 0.05
Name: P73745_SYNY3 Len: 1276 Check: 9582 Weight: 0.03
Name: P74477_SYNY3 Len: 1276 Check: 865 Weight: 0.05
Name: P93567_SOLTU Len: 1276 Check: 1560 Weight: 0.03
Name: P96820_MYCTU Len: 1276 Check: 254 Weight: 0.04
Name: Q17804_CAEEL Len: 1276 Check: 6861 Weight: 0.03
Name: Q18368_CAEEL Len: 1276 Check: 7570 Weight: 0.04
Name: Q22833_CAEEL Len: 1276 Check: 2256 Weight: 0.03
Name: Q9BHB2_CAEEL Len: 1276 Check: 8681 Weight: 0.03
Name: Y305_METJA Len: 1276 Check: 6815 Weight: 0.05
Name: Alignment Len: 1276 Check: 7490 Weight: 1.00
Name: Domain Len: 1276 Check: 6070 Weight: 1.00
Name: Secondary Len: 1276 Check: 9876 Weight: 1.00
Name: FunctionalAA Len: 1276 Check: 1520 Weight: 1.00

//

1 50
CICH_TORMA ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~MSHEKNEA
CLCA_ARATH ~~~~~~~~~~ ~~~~~~~~~M DEDGNLQISN SNYNGEEEGE DPENNTLNQP
CLCA_ECOLI ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
CLCD_ARATH ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~MLSNH LQNGIESDNL
CLCKA_HUMAN ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~MEELVGL
CLCN1_RAT ~~~~~~~~~~ ~~~~~MERSQ SQQHGGEQSW WGTAPQYQYM PFEHCTSYGL
CLCN2_HUMAN ~~~~~~~~~~ MAAAAAEEGM EPRALQHEQT LMYGRYTQDL GAFAKEEAAR
CLCN3_RAT ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~MTNGG
CLCN6_HUMAN ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~MAGCR GSLCCCCRWC CCCGERETRT
CLCN7_RAT MANVSKKVSW SGRDRDDEEG APLLRRTGQP DEETPLLNGA GPGARQSHSA
GEF1_YEAST ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~M PTTYVPINQP
O13080_XENLA ~~~~~~~~~~ ~~~~~~~~~M DNKGFRRSSL ASFHSNTSDE DMVEITEATL
O28857_ARCFU ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O57747_PYRHO ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O60159_SCHPO ~~~~~~~~~~ ~~~~~~~~~~ MSSQKRADSS SSFDQAERRS LDENERKKKY
O60958_LEIMA ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~MHS SLPMAEQTAR
O94287_SCHPO ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
P73745_SYNY3 ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
P74477_SYNY3 ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
P93567_SOLTU ~~~~~~~~~~ ~~~~~~~~~~ ~~~~MIEEEK FDLERNFSTI SESGSIRVPL
P96820_MYCTU ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Q17804_CAEEL ~~~~~~~~~~ ~~~~~~~~~~ ~~~MERAGRS STLGSTDDVE LEPSGTSATI
Q18368_CAEEL ~~~~~~~~~~ ~~~~~~~~~~ ~~~MDPLAKV SILSPLAMLQ MHHHKPKKSW
Q22833_CAEEL ~~~MEDAVVV DEEHRRRGED TQSSGQSSLP SDIVQFTARP HMLMEDVECS
Q9BHB2_CAEEL ~~~~~~~~~~ ~~~~~~~~~M TSRNRVRTSS NSLDPNEDPV SGLERVMSNS
Y305_METJA ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Alignment .......... .......... .......... .......... ..........
Domain .......... .......... .......... .......... ..........
Secondary .......... .......... .......... .......... ..........
FunctionalAA .......... .......... .......... .......... ..........

51 100
CICH_TORMA SGYPEAQSWK SQEAMLGA~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~RTEV
CLCA_ARATH LLKRHRTLSS TPLALVGAKV S~~~~~~~~~ ~~~~~~~~~~ ~~~~~~HIES
CLCA_ECOLI ~~~~~~~~~~ ~MKTDTP~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~SLET
CLCD_ARATH LWSRVPESDD TSTDDITLLN SHRDGDG~~~ ~~~~~~~~~~ ~~~~~~GVNS
CLCKA_HUMAN REGFSGDPVT LQELWGP~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
CLCN1_RAT PSENGGLQHR PRKDLGPRHN AHPTQIYGHH KEQYSYQAQD RGIPKKTDSS
CLCN2_HUMAN IRLGGPEPWK GPPSSRA~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~APEL
CLCN3_RAT SINSSTHLLD LLDEPIPGVG TYD~~~~~~~ ~~~~~~~~~~ ~~~~~~DFHT
CLCN6_HUMAN PEELTILGET QEEEDEILPR K~~~~~~~~~ ~~~~~~~~~~ ~~~~~~DYES
CLCN7_RAT LFRIGQMNNV ELDDELLDPE VDPPHTFPKE IPHNEKLLSL ~~~~~~KYES
GEF1_YEAST IRDGEDVIDT NRFTNIP~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~ETQN
O13080_XENLA DFTMTDDVPP IDRDMAAGFV SYNGNGLNGG AKVMDFLDVP GVGTYEDFNT
O28857_ARCFU ~~~~~~~~~M KRRAPLS~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O57747_PYRHO ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O60159_SCHPO FFNREGSGID NFETDGMVFQ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~ASKA
O60958_LEIMA AGGGGGGGAG NGADESITNL VVNVSEA~~~ ~~~~~~~~~~ ~~~~~~DWAT
O94287_SCHPO ~~~~~~~~~~ MKDDQLI~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
P73745_SYNY3 ~~~MAADFET SNRRWLD~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
P74477_SYNY3 ~~~~~~~~~~ ~~MAWFP~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
P93567_SOLTU LKSKSRVNNT SQIAIVGANV Y~~~~~~~~~ ~~~~~~~~~~ ~~~~~~PIES
P96820_MYCTU ~~~~~~~~~M APGDWSV~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Q17804_CAEEL HLDMTAGGGS SSSDFNP~FG AIDDVRFKTD DDLPDVMAPP FFSKYGDFHT
Q18368_CAEEL VRSVMSDVKR SLLDMSPGGK TDD~~~~~~~ ~~~~~~~~~~ ~~~~~~ADEE
Q22833_CAEEL PIEPTEKEWN EYRDRVQENA DQMELLGDDE SSDTEDQNDL ~~~~~~DEEY
Q9BHB2_CAEEL NLEHVARQRR RLEEELLFSR QLDDVGRTDS HEALSA~~~~ ~~~~~~RYES
Y305_METJA ~~~~~~~MPM NIVNMFG~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Alignment .......... .......... .......... .......... ..........
Domain .......... .......... .......... .......... ..........
Secondary .......... .......... .......... .......... ..........
FunctionalAA .......... .......... .......... .......... ..........

101 150
CICH_TORMA SRWRAVKNCL YR~~~~~~~~ ~~~~~~~~~~ ~~~~HLVKVL GEDWIFL~LL
CLCA_ARATH LDYEINENDL FKHDWRSRSK A~~~~~~~~~ ~~~~QVFQYI FLKWTLA~CL
CLCA_ECOLI PQAARLRRRQ LIRQLLERDK T~~~~~~~~~ ~~~~~~~~~~ PLAILFMAAV
CLCD_ARATH LDYEVIENYA YREEQAHRGK L~~~~~~~~~ ~~~~YVGYYV AVKWFFS~LL
CLCKA_HUMAN ~~~CPHIRRA IQGGLEWLKQ K~~~~~~~~~ ~~~~~~VFRL GEDWYFL~MT
CLCN1_RAT STVDSLDEDH YSKCQDCVHR L~~~~~~~~~ ~~GRVLRRKL GEDWIFL~VL
CLCN2_HUMAN LEYGRSRCAR CRVCSVRCHK F~~~~~~~~~ ~~~~~LVSRV GEDWIFL~VL
CLCN3_RAT IDWVREKCKD RERHRRINSK K~~~~~KESA WEMTKSLYDA WSGWLVV~TL
CLCN6_HUMAN LDYDRCINDP YLEVLETMDN K~~~~~~~~~ ~~~~KGRRYE AVKWMVV~FA
CLCN7_RAT LDYDNSENQL FLEEERRINH T~~~~~~~~~ ~~~~AFRTVE IKRWVIC~AL
GEF1_YEAST FDQFVTIDKI AEENRPLSVD SDREFLNSKY RHYREVIWDR AKTFITL~SS
O13080_XENLA IDWVREKSRD RDRHREILSR S~~~~~KEST WALLHSVSDA FSGWMLM~LL
O28857_ARCFU ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ SKYLILLAAI
O57747_PYRHO ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~MLKL~IL
O60159_SCHPO FDYYLLTTFK DRVNEIINEQ NEENVIDQSR WSKLWRIWNV GYSWFIL~SI
O60958_LEIMA IDCIRSHTEA AERAAMWRRH SATAAASSSY GDKWSVYSPE GEAFFAA~MA
O94287_SCHPO ~DWIHERYEE QKSANRLAGR F~~~~~~~~~ ~~~~RFLGLE TKYSIIS~II
P73745_SYNY3 ~~~~KLPRNL TDSARSLHPR T~~~~~~~~~ ~~~~~~~~~~ ~~~~LVAAIV
P74477_SYNY3 ~FWQRWQQWL RSRHYGRTAI D~~~~~~~~~ ~~~~~~~~~~ SRYAIAEACV
P93567_SOLTU LDYDIVENDL FKQDWRSRKK V~~~~~~~~~ ~~~~EIFQYI FLKWTLV~LL
P96820_MYCTU FAWHAANLPT MPEAEDIGNE A~~~~~AGGR FGVSIRSAGY LRKWFLLGIT
Q17804_CAEEL IDWQRDLARD RLRHKMISKK K~~~~~VDFP LGLLQSGWDA GAGWICV~LF
Q18368_CAEEL PDDHVESNET FAEFCTRQAQ N~~~~~~~~~ ~~~~~VVHFL VEDWFLS~AL
Q22833_CAEEL EDYYTDSKST RRETTKEFLT R~~~~~~~~~ ~QFQNIVHFF VEDWFIS~AA
Q9BHB2_CAEEL LNYEISENRL YRDAEKKPSH Q~~~~~~~~~ ~~~LTLWRIS RNRWFVC~FL
Y305_METJA ~KYIK~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ IIKWIGIASL
Alignment .......... .......... .......... .......... XXXAAAAAAA
Domain .......... .......... .......... .......... ..........
Secondary ......HHHH HHHHHH.... .......... .......... HHHHHHHHHH
FunctionalAA .......... .......... .......... .......... ..........

151 200
CICH_TORMA LGALMALVSW AMDFIGSRGL RFYK~~~YLF ALVEGNIG~~ ~~~~~~~~~~
CLCA_ARATH VGLFTGLIAT LINLAVENIA GYKLLAVGYY IAQDRFW~~~ ~~~~~~~~~~
CLCA_ECOLI VGTLVGLAAV AFDKGVAWLQ NQRM~~~GAL VHTADNYP~~ ~~~~~~~~~~
CLCD_ARATH IGIGTGLAAV FINLSVENFA GWKF~~~ALT FAIIQKSYF~ ~~~~~~~~~~
CLCKA_HUMAN LGVLMALVSY AMNFAIGCVV RAHQ~~~WLY REIGDSHL~~ ~~~~~~~~~~
CLCN1_RAT LGLLMALVSW CMDYVSAKSL QAYK~~~WTY AQMQPSLP~~ ~~~~~~~~~~
CLCN2_HUMAN LGLLMALVSW VMDYAIAACL QAQQ~~~WMS RGLNTSIL~~ ~~~~~~~~~~
CLCN3_RAT TGLASGALAG LIDIAADWMT DLKE~~~GIC ~~LSALWYNH EQCCWG~~~~
CLCN6_HUMAN IGVCTGLVGL FVDFFVRLFT QLKF~~~G~V ~~VQTSVE~~ ~~~~~~~~~~
CLCN7_RAT IGILTGLVAC FIDIVVENLA GLKY~~~R~V ~~IKDNID~~ ~~~~~~~~~~
GEF1_YEAST TAIVIGCIAG FLQVFTETLV NWKT~~~GHC ~~QRNWLLNK SFCCNGVVNE
O13080_XENLA IGLTAGSLAG LIDISSHWMT DLKE~~~GIC ~~LPWFWFNH EQCCWQ~~~~
O28857_ARCFU VGVISGLGAF IFYFLLDLFT KIFL~~~SGL ~~DSFNPP~~ ~~~~~~~~~~
O57747_PYRHO VGILVGLIVG AYKVLVCLVG DLYP~~~AIS ~~EGIRRD~~ ~~~~~~~~~~
O60159_SCHPO IGTTVGFAAY MLDIVTSWLS DIRR~~~GYC ~~TSHWYYNE KFCCWYSETM
O60958_LEIMA CGIVLGCLGV FSDACAHWVS AFRS~~~GIC ~~ANFFWLGR NMCCV~~~~~
O94287_SCHPO SGIFIGLTAA LLNALASLLN SFRE~~~GYC ~~TVNILFDK QTCCSTLTED
P73745_SYNY3 VGLITGVLGA GFKSAVNNML QWRS~~~QLA QILAPIPP~~ ~~~~~~~~~~
P74477_SYNY3 IGFVSALAAL VIKNGVNWLG SSRL~~~SLA ~~DTY~~~~~ ~~~~~~~~~~
P93567_SOLTU IGLSTGLVGF FNNIGVENIA GFKL~~~LLT ~~SNLMLD~~ ~~~~~~~~~~
P96820_MYCTU IGVIAGLGAV VFYLALKYTS EFLL~~~GYL ~~ADYQIP~~ ~~~~~~~~~~
Q17804_CAEEL VGLAAGATAG IIDIGARWMS DLKT~~~GVC ~~ADRFWLDH EHCCWS~~~~
Q18368_CAEEL LGIITAVLSV GMDVAIEVLQ HAHV~~~TFY DKMLAISSY~ ~~~~~~~~~~
Q22833_CAEEL LGFITAIFSI FIDMGIEYLI HFRN~~~FML ESLEQFNNY~ ~~~~~~~~~~
Q9BHB2_CAEEL IGVFTGLVAA FIDIMVHYSK DIKF~~~NWI ~~LKYLLS~~ ~~~~~~~~~~
Y305_METJA IGIVGGLSSV IIAIIIEYFP EKHN~~~V.. ~~~~~~~~~~ ~~~~~~~~~~
Alignment AAAAAAAAAA AAAAAAXXXX XXXXXXXXXX XXX....... ..........
Domain .......... .......... .......... .......... ..........
Secondary HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHH..HHHHH HHHHHHHHHH
FunctionalAA .......... .......... .......... .......... ..........

201 250
CICH_TORMA ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~LQYLV
CLCA_ARATH ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~TGLMV
CLCA_ECOLI ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~LLLTV
CLCD_ARATH ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~AGFIV
CLCKA_HUMAN ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~LRYLS
CLCN1_RAT ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~LQYLA
CLCN2_HUMAN ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~LQYLA
CLCN3_RAT ~~~S~~~~NE TTFEERD~KC PQ~~~WKTWA ELIIGQAEGP GSYI~MNYIM
CLCN6_HUMAN ~~~~~~~~~~ ~~~~~~~~EC SQK~~~~~~G CLA~~~~~~~ ~~~~~LSLLE
CLCN7_RAT ~~~~~~~~~~ ~~~~~~~~KF TEK~~~~~~G GLS~~~~~~~ ~~~~~FSLLL
GEF1_YEAST VTST~~~~SN LLLKRQEFEC EAQGLWIAWK GHV~~~~~~~ ~~~~~SPFII
O13080_XENLA ~~~S~~~~NN VTFEDRN~NC PE~~~WRSWS QLVLGRSEGA FPYI~LNYFM
O28857_ARCFU ~~~~~~~~~~ ~~~~~~~~LA GGEAEVVKIE LH~~~~~~~~ ~~~~~LGILP
O57747_PYRHO ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~IRFAL
O60159_SCHPO GMFKHDLYND LTFQGSS~~C TA~~~WKPWT YKFS~~~~~~ ~~~~~LNYLI
O60958_LEIMA ~~~~~~~~~~ ~~~~~~~~DC RECGEYYSWG EFFLGRDNHV VAF~~VDFVM
O94287_SCHPO Y~~~~~~~~~ ~~~~~~~~EC QEFFFWRNNH SVF~~~~~~~ ~~~~~VSCLI
P73745_SYNY3 ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~LAWLV
P74477_SYNY3 ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~GAIWV
P93567_SOLTU ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~G KYF~~~~~~~ ~~~~~QAFAA
P96820_MYCTU ~~~~~~~~~~ ~~~~~~~~TP VGEGGHRGST GF~~~~~~~~ ~~~~~ARPWA
Q17804_CAEEL ~~~S~~~~ND TFYKD~D~DC KA~~~WTKWP WMLNYYNSSS FLFLFLEWIF
Q18368_CAEEL ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~LAFSQ
Q22833_CAEEL ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~AAFCG
Q9BHB2_CAEEL ~~~~~~~~~~ ~~~~~~~~KC GEEQRGTTAG CMW~~~~~~~ ~~~~~TVMIA
Y305_METJA ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Alignment .......... .......... .......... .......... .....AAAAA
Domain .......... .......... .......... .......... ..........
Secondary HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH
FunctionalAA .......... .......... .......... .......... ..........

251 300
CICH_TORMA WVCYPLALIL FSSLFCQIVS PQAVGSGIPE LKTIIRGAVL ~HE~~~YLTL
CLCA_ARATH FTGANLGLTL VATVLVVYFA PTAAGPGIPE IKAYLNGIDT ~PN~~~MFGF
CLCA_ECOLI AFLCSAVLAM FGYFLVRKYA PEAGGSGIPE IEGALEDQRP ~~~~~~VRWW
CLCD_ARATH YLLINLVLVF SSAYIITQFA PAAAGSGIPE IKGYLNGIDI ~PG~~~TLLF
CLCKA_HUMAN WTVYPVALVS FSSGFSQSIT PSSGGSGIPE LKTMLAGVIL ~ED~~~YLDI
CLCN1_RAT WVTFPLILIL FSALFCQLIS PQAVGSGIPE MKTILRGVVL ~KE~~~YLTL
CLCN2_HUMAN WVTYPVVLIT FSAGFTQILA PQAVGSGIPE MKTILRGVVL ~KE~~~YLTL
CLCN3_RAT YIFWALSFAF LAVSLVKVFA PYACGSGIPE IKTILSGFII ~RG~~~YLGK
CLCN6_HUMAN LLGFNLTFVF LASLLV~LIE PVAAGSGIPE VKCYLNGVKV ~PG~~~IVRL
CLCN7_RAT WATLNSAFVL VGSVIVAFIE PVAAGSGIPQ IKCFLNGVKI ~PH~~~VVRL
GEF1_YEAST FMLLSVLFAL ISTLLVKYVA PMATGSGISE IKVWVSGFEY NKE~~~FLGL
O13080_XENLA YVMWALLFSL LAVLLVRNFA PYACGSGIPE IKTILSGFII ~RG~~~YLGK
O28857_ARCFU LPVVVALGGL LSGLIVYKFA PEAEGHGTDA VIRAFHRARG ~~~~~~EIRA
O57747_PYRHO LWFLFTVLAI FTVEVMLKKE PAASSGGINQ MYLVLHGILR ~~~~~~YNPV
O60159_SCHPO YTAFALLFVL CAAIMVRDVA PLAAGSGISE IKCIISGFLR ~DS~~~FLSF
O60958_LEIMA YVSFSTMAAV TAAYLCKTYA PYASGGGIAE VKTIVSGHHV ~KR~~~YLGG
O94287_SCHPO YVSVSVGFAF IATTLGYVVA PAARASGIPT IKAILSGYKY ~PDMNVFFSI
P73745_SYNY3 TALISGGMVA LSFWLMKRFA PDTSGSGIPQ IEGHLEGKLP ~~~~~~LVWQ
P74477_SYNY3 LPCFGLVFGG LAGALIEQFS RPAGGGGIPQ VKAALARYPI ~~~~~~PLDW
P93567_SOLTU FAGCNVFFAT CAAALCAFIA PAAAGSGIPE VKAYLNGIDA ~HS~~~ILAP
P96820_MYCTU IPLVTTGGAV LSALIVAKLA PEATGHGTDE AIESVHGDPR ~~~~~~AIRG
Q17804_CAEEL YIGWAVAMST LAVLFVKIFA PYACGSGIPE IKCILSGFVI ~RG~~~YLGK
Q18368_CAEEL WVAHIVILTM FAAIFCQIVS KQAVGSGIPE VKVIMHGFKM ~EN~~~YLTT
Q22833_CAEEL WVFYITGLVY LAALVCYGFG KQAVGSGIPE VKVIIHGFQL ~KN~~~YLSG
Q9BHB2_CAEEL WIGYNCVLVT IAAILVIYVA PIAGGSGIPQ IKCYLNGIAI ~PE~~~VVRL
Y305_METJA ~~~LLIPIVF FIAGLFVDYI YELKGSGIDR VLKALNTNEK ~~~~~~LTWI
Alignment AAAAAAXXXX XXXXAAAAAA AAAAAAAAAA AAAAAAALLL LLLLLLLAAA
Domain ...DDDDDDD DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD
Secondary HHHHHHHHHH HHHHHHHHHH HHHH..HHHH HHHHHH.... ........HH
FunctionalAA .......... .......... ....MMMMM. .......... ..........

301 350
CICH_TORMA RTFVAKTVGL TVALSAG~~F PLGKEGPFVH IASICATLLN ~~~~~~~~~~
CLCA_ARATH TTMMVKIVGS IGAVAAG~~L DLGKEGPLVH IGSCIASLLG QGGPDNHRIK
CLCA_ECOLI RVLPVKFFGG LGTLGGG~~M VLGREGPTVQ IGGNIGRMVL ~~~~~~~~~~
CLCD_ARATH RTLIGKIFGS IGSVGGG~~L ALGKEGPLVH TGACIASLLG QGGSTKYHLN
CLCKA_HUMAN KNFGAKVVGL SCTLATGSTL FLGKVGPFVH LSVMIAAYLG RVR~~~~~~~
CLCN1_RAT KAFVAKVVAL TAGLGSG~~I PVGKEGPFVH IASICAAVLS KFM~~~~~~~
CLCN2_HUMAN KTFIAKVIGL TCALGSG~~M PLGKEGPFVH IASMCAALLS KFL~~~~~~~
CLCN3_RAT WTLMIKTITL VLAVASG~~L SLGKEGPLVH VACCCGNIFS ~~~~~~~~~~
CLCN6_HUMAN RTLLCKVLGV LFSVAGG~~L FVGKEGPMIH SGSVVGAGLP QFQSISLRKI
CLCN7_RAT KTLVIKVSGV ILSVVGG~~L AVGKEGPMIH SGSVIAAGIS QGRSTSLKRD
GEF1_YEAST LTLVIKSVAL PLAISSG~~L SVGKEGPSVH YATCCGYLLT ~~~~~~~~~~
O13080_XENLA WTLIIKTMTL VLAVSSG~~L SLGKEGPLIH VACCCGNILC ~~~~~~~~~~
O28857_ARCFU RVPIVKTIAS AITIGSG~~G SAGREGPIAQ IGAGFGSFVG ~~~~~~~~~~
O57747_PYRHO KVILTKIFGS LLVIMSG~~F SLGRVGPSVQ LGGSLAMVLG ~~~~~~~~~~
O60159_SCHPO RVMLVKCVGL PLAIASG~~L SVGKEGPSVH LATTIGHNIS ~~~~~~~~~~
O60958_LEIMA WTLITKVVGM CFSTGSG~~L TVGKEGPFVH IGACVGGIIS ~~~~~~~~~~
O94287_SCHPO KTLCSKSLAV CFSVASG~~L WVGKEGPFVH IATNIIYLVE ~~~~~~~~~~
P73745_SYNY3 RVLPIKLVGG FLSLGAG~~M LAGFEGPTIQ MGGSIGQMTG ~~~~~~~~~~
P74477_SYNY3 RVAVVKLLGT VLVLGGG~~M TLGRRAPTVH IGAALAAQLS ~~~~~~~~~~
P93567_SOLTU STLLVKIFGS ILGVSAG~~F VVGKEGPMVH TGACIANLLG QGGSRKYHLT
P96820_MYCTU RAVLVKMVAS ALTIGSG~~G SGGREGPTAQ ISAGFCSLLT ~~~~~~~~~~
Q17804_CAEEL WTFIIKSVGL ILSSASG~~L SLGKEGPMVH LACCIGNIFS ~~~~~~~~~~
Q18368_CAEEL RTLVAKMVGL TLAMGGG~~L PIGKEGPFVH MGAIVATLLS KITSAC~~~~
Q22833_CAEEL KTLIAKMIGL TLTIGSG~~L PVGKEGPFVH IGAIVASLLN KVTAAC~~~~
Q9BHB2_CAEEL KTLVSKAVGV ACSVGGG~~L CAGKEGPMIH SGAAVGAGIS QGKSYSLGID
Y305_METJA RGLLKVLLAG AV~IAVG~~G SAGKEGPCVQ SSASFADELY ~~~~~~~~~~
Alignment AAAAAAAAAA AAAAAAA..A AAAAAAAAAA AAAAAAAAA. ..........
Domain DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD
Secondary HHHHHHHHHH HHHHHH.... ...HHHHHHH HHHHHHHHHH HHHHHHHHHH
FunctionalAA .......... .......... ..MMSMM... .......... ..........

351 400
CICH_TORMA ~QLLCFISGR REEPYYLRAD ILTVGCALGI SCCFGTPLAG VLFSIE~~~~
CLCA_ARATH WRWLRYFNN~ DRD~~~~RRD LITCGSASGV CAAFRSPVGG VLFALE~~~~
CLCA_ECOLI ~DIFRLKG~~ DEA~~~~RHT LLATGAAAGL AAAFNAPLAG ILFIIE~~~~
CLCD_ARATH SRWPQLFKS~ DRD~~~~RRD LVTCGCAAGV AAAFRAPVGG VLFALE~~~~
CLCKA_HUMAN ~TTTIGEPEN KSK~~~~QNE MLVAAAAVGV ATVFAAPFSG VLFSIE~~~~
CLCN1_RAT ~SMFSGVYEQ PYY~~~~YTD ILTVGCAVGV GCCFGTPLGG VLFSIE~~~~
CLCN2_HUMAN ~SLFGGIYEN ESR~~~~NTE MLAAACAVGV GCCFAAPIGG VLFSIE~~~~
CLCN3_RAT ~YLFPKYSTN EAK~~~~KRE VLSAASAAGV SVAFGAPIGG VLFSLE~~~~
CLCN6_HUMAN QFNFPYFRS~ DRD~~~~KRD FVSAGAAAGV AAAFGAPIGG TLFSLE~~~~
CLCN7_RAT FKIFEYFRR~ DTE~~~~KRD FVSAGAAAGV SAAFGAPVGG VLFSLE~~~~
GEF1_YEAST ~KWLLRDTLT YST~~~~QYE YLTAASGAGV AVAFGAPIGG VLFGLE~~~~
O13080_XENLA ~HLFTKYRKN EAK~~~~RRE VLSAAAAAGV SVAFGAPIGG VLFSLE~~~~
O28857_ARCFU ~ELLRLS~~~ DKD~~~~RRI LVICGVAGGI GSIFRSPFGG AMFGIE~~~~
O57747_PYRHO ~~~~~~~~~~ ~~~~~~~~EG LIDAGIAAGV AATLEAPITG VVFTLE~~~V
O60159_SCHPO ~KIFKYAREG SIR~~~~YRD ICVASAASGV AVAFGSPIGG VLFGIEVGKF
O60958_LEIMA ~GALPSYQQ~ EAK~~~~ERE LITAGAGGGM AVAFGAPVGG VIFALE~~~~
O94287_SCHPO ~RIAPSLADS EIF~~~~TRQ LLAAAMASGI AASFNAPVGG VIFALE~~~~
P73745_SYNY3 ~GWFKAT~~~ QEN~~~~QRI LIAVGAGAGL ATAFNAPLAG VALIGE~~~~
P74477_SYNY3 ~RWFPTS~~~ PEH~~~~RRQ MIAAGAAAGL AAGFTTPIAG VLFVVE~~~~
P93567_SOLTU WKWLKYFKN~ DRD~~~~RRD LITCGAAAGV AAAFRAPVGG VLFALE~~~~
P96820_MYCTU ~RRLNLS~~~ NED~~~~GRT AVALGIGAGI GAIFAAPLGG AALGAS~~~~
Q17804_CAEEL ~YLFPKYGLN EAK~~~~KRE ILSASAAAGV SVAFGAPIGG VLFSLE~~~~
Q18368_CAEEL ~QYSAFFSN~ EGR~~~~EME MLSSGCAVGI ACTFSAPIGA VLYAIE~~~~
Q22833_CAEEL ~QYNAFFSN~ EGR~~~~AME MLSIGCAVGI ACTFSAPMGA VLYGIE~~~~
Q9BHB2_CAEEL FGLFREFRN~ DRE~~~~KRD FVSAGAAAGV AAAFGAPIGG VLFSLE~~~~
Y305_METJA ~RLLKL~~~~ ~KN~~~~REL VIITGIAGGL GGAFSAPLGT AILACE~~~~
Alignment .......... ........AA AAAAAAAAAA AAAAAAAAAA AAAAAA....
Domain DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD
Secondary HHHH...HHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHH.....
FunctionalAA .......... .......... .......... .......... ..........

401 450
CICH_TORMA ~VT~~CSH~~ ~~~~FGVR~~ SYWRGFLGGA FSAFIFRVL~ ~~~~~SVWVK
CLCA_ARATH ~EV~~ATW~~ ~~~~WRSA~~ LLWRTFFSTA VVVVVLRAFI EICNSGKCGL
CLCA_ECOLI ~EMRPQFR~~ ~~~~YTLI~~ SIKAVFIGVI MSTIMYRIF~ ~~~~~~~~~~
CLCD_ARATH ~EV~~TSW~~ ~~~~WRSQ~~ LMWRVFFTSA IVAVVVRTAM GWCKSGICGH
CLCKA_HUMAN ~VM~~SSH~~ ~~~~FSVR~~ DYWRGFFAAT CGAFIFRLL~ ~~~~~AVFNS
CLCN1_RAT ~VT~~STY~~ ~~~~FAVR~~ NYWRGFFAAT FSAFVFRVL~ ~~~~~AVWNK
CLCN2_HUMAN ~VT~~STF~~ ~~~~FAVR~~ NYWRGFFAAT FSAFIFRVL~ ~~~~~AVWNR
CLCN3_RAT ~EV~~SYY~~ ~~~~FPLK~~ TLWRSFFAAL VAAFVLRSI~ ~~~~~~~~NP
CLCN6_HUMAN ~EG~~SSF~~ ~~~~WNQG~~ LTWKVLFCSM SATFTLNFFR SGIQFGSWGS
CLCN7_RAT ~EG~~ASF~~ ~~~~WNQF~~ LTWRIFFASM ISTFTLNFVL SIYHGNMWDL
GEF1_YEAST ~EIASANR~~ ~~~~FNSS~~ TLWKSYYVAL VAITTLKYI~ ~~~~~~~~DP
O13080_XENLA ~EV~~SYY~~ ~~~~FPLK~~ TLWRSFFAAL VAAFTLRSI~ ~~~~~~~~NP
O28857_ARCFU ~VLYKRD~~~ ~~~~NEVE~~ AIVPAFVSSI VAFIVFDVI~ ~~~~MSYFAN
O57747_PYRHO FKIRPTLY~~ ~~~~KIVT~~ LLFASVPAAL VSKLMFP~~~ ~~~~~~~~~~
O60159_SCHPO IEILTNSFKE MSGGYDPK~~ MIVYSFFCCL SAVGVLHML~ ~~~~~~~~NP
O60958_LEIMA ~DV~~STS~~ ~~~~YNFK~~ ALMAALICGV TAVLLQSRV~ ~~~~~~~~DL
O94287_SCHPO ~QLASSSF~~ ~~~~PSLFTG SIWYEFLCSA SSVVALQLI~ ~~~~~~~~RS
P73745_SYNY3 ~EMHPRFR~~ ~~~~SQTL~~ AYHSLLFGCV MATIILRMI~ ~~~~~~~~~~
P74477_SYNY3 ~ELMRDVS~~ ~~~~SLTLET AIVASFVGA~ VTSLVFQ~~~ ~~~~~~~~SS
P93567_SOLTU ~EI~~ASW~~ ~~~~WRSA~~ LLWRTFFTTA IVAMVLRSLI QFCRGGNCGL
P96820_MYCTU ~IPYRDD~~~ ~~~~FDYR~~ NLLPGFIASG TAYAVLG~~~ ~~~~~AFLGF
Q17804_CAEEL ~EA~~SYY~~ ~~~~FPLK~~ TMWRSFFCAL VAGIILRFV~ ~~~~~~~~NP
Q18368_CAEEL ~ST~~SKY~~ ~~~~FAVK~~ NYWRGFLAAT CSAIVFRCA~ ~~~NFFVTAE
Q22833_CAEEL ~ST~~SKY~~ ~~~~FAVK~~ NYWRSFFATT CSAMLFRFA~ ~~IAFFVPQH
Q9BHB2_CAEEL ~EG~~ASF~~ ~~~~WNQA~~ LTWRMFFSAM ISSFTVNWIL SWFN~GRSGW
Y305_METJA ~IIEHEN~~~ ~~~~FNYI~~ NLIPPIIASV VGYLIFYLI~ ~~~~~~~~~~
Alignment .......... .......... AAAAAAAAAA .......... ..........
Domain DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD
Secondary .......... .......... HHHHHHHHHH .......... ..........
FunctionalAA .......... .......... .......... .......... ..........

451 500
CICH_TORMA DTVTLTALFK TNFRGDIP~~ ~~~FDLQEMP AFAIIGIASG FFGALFVYLN
CLCA_ARATH FGSGGLIMFD VSHVEVR~~~ ~~~YHAADII PVTLIGVFGG ILGSLYNHL~
CLCA_ECOLI ~~NHEVALID VGKLSD~~~~ ~~~APLNTLW LYLILGIIFG IFGPIFNKWV
CLCD_ARATH FGGGGFIIWD VSDGQDD~~~ ~~~YYFKELL PMAVIGVIGG LLGALFNQLT
CLCKA_HUMAN EQETITSLYK TSFRVDVP~~ ~~~FDLPEIF FFVALGGICG VLSCAYLFCQ
CLCN1_RAT DAVTITALFR TNFRMDFP~~ ~~~FDLKELP AFAVIGICCG FLGAVFVYLH
CLCN2_HUMAN DEETITALFK TRFRLDFP~~ ~~~FDLQELP AFAVIGIASG FGGALFVYLN
CLCN3_RAT FGNSRLVLFY VEYHTP~~~~ ~~~WYLFELF PFILLGVFGG LWGAFFIRAN
CLCN6_HUMAN FQLPGLLNFG EFKCSDSDKK CHLWTAMDLG FFVVMGVIGG LLGATFNCLN
CLCN7_RAT SSPGLINFGR FDSEKMA~~~ ~~~YTIHEIP VFIAMGVVGG ILGAVFNALN
GEF1_YEAST FRNGRVILFN VTYDRD~~~~ ~~~WKVQEIP IFIALGIFGG LYGKYISKWN
O13080_XENLA FGNSRLVLFY VEFHAP~~~~ ~~~WHLLELI PFILLGIFGG VWGAFFIRAN
O28857_ARCFU TPFGVLPIFK IPQVTI~~~~ ~~~HSPLEFP IYAIVSVLAA FFGIIYVKVF
O57747_PYRHO ~~~~~~MRFW PSFEYS~~~~ ~~~YGLFDYL LILLLGIFTG LYSSAFMQLL
O60159_SCHPO FRTGQVVLFE VRYSGS~~~~ ~~~WHFFELL FFCFLGIFGG LYGEFVMRLF
O60958_LEIMA WHTGRIVQFS VNYQHN~~~~ ~~~WHFFELP MFAAIGCFGG FMGSTFSVVN
O94287_SCHPO WHTDVGYLSY VSLDRR~~~~ ~~~WSYKDTL PFIFISILCG CLGSVLIYLN
P73745_SYNY3 ~~RGQSAIIS LTEFKR~~~~ ~~~VPLDSLW MFIILGILFG VMGYTFNRGL
P74477_SYNY3 DLNLAHSLSN SPTVR~~~~~ ~~~FTTGEIP FYLLLGILAG ILGVLLNRSI
P93567_SOLTU FGQGGLIMFD VNSGVSN~~~ ~~~YNTIDVL ALIFIGVLGG LLGSLYNYL~
P96820_MYCTU DPLFGYIDAE YRFEKA~~~~ ~~~WP~~~LL WFVVIGLIAA AVGYLYARVF
Q17804_CAEEL FGSNQTSLFH VDYMMK~~~~ ~~~WTFIELV PFAILGLFGG IIGSLFIFAN
Q18368_CAEEL QSGTITAFYQ TRFPTDC~~~ ~~~FLVEELP IFLLLGFISG LMGSFFIFIH
Q22833_CAEEL IAGTITAYYQ TYFPNEV~~~ ~~~FVVEELP FFIGLGVMTG LLGALFVYYH
Q9BHB2_CAEEL LSWTGLANFG VFENKD~~~~ ~~~YNIWEIP LFLLIGIIGG CLGALFNYLN
Y305_METJA ~~TGRKHLFN ITLSYT~~~~ ~~~INIHDFL LFILGAFFCS LIAHCYIKTY
Alignment .......... .......... ...AAAAAAA AAAAAAAAAA AAAAAAAAAX
Domain DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD
Secondary .......... .......... ....HHHHHH HHHHHHHHHH HHHHHHHHHH
FunctionalAA .......... .......... .......... .......... ..........

501 550
CICH_TORMA RQIIVFMRKK NFVTKILKKQ RLIYPAVVTF VLATLR~FPP GVGQFFGAGL
CLCA_ARATH LHKVLRLYNL ~~INQKGKIH KVLLSLGVSL FTSVCL~FGL PF~~~~~~LA
CLCA_ECOLI LGMQDLLHRV ~~HGGNITKW VLMGGAIGG~ LCGLLG~FVA PAT~~~~~SG
CLCD_ARATH LYMTSWRRNS ~~LHKKGNRV KIIEACIISC ITSAIS~FGL PL~~~~~~LR
CLCKA_HUMAN RTFLSFIKTN RYSSKLLATS KPVYSALATL LLASIT~YPP GVGHFLASRL
CLCN1_RAT RQVMLGVRKH KALSQFLAKH RLLYPGIVTF VIASLT~FPP GMGQFMAGEL
CLCN2_HUMAN RKIVQVMRKQ KTINRFLMRK RLLFPALVTL LISTLT~FPP GFGQFMAGQL
CLCN3_RAT IAWCRRRKST ~~~~~KFGKY PVLEVIIVAA ITAVIA~FPN PYT~~~~~RL
CLCN6_HUMAN KRLAKYRMRN ~~VHPKPKLV RVLESLLVSL VTTVVV~FVA SMV~~~~~LG
CLCN7_RAT YWLTMFRIRY ~~~~IHRPCL QVIEAMLVAA VTATVA~FVL IYS~~~~~SR
GEF1_YEAST INFIHFRKMY ~~~~~~LSSW PVQEVLFLAT LTALIS~YFN EFL~~~~~KL
O13080_XENLA IAWCHRRKTT ~~~~~KLGRY PVAEVLMVTA ITAILA~FPN DYT~~~~~RM
O28857_ARCFU YTVHNYSKRV ~~~~~~~SIP PYFKPAIGGF FTGVIGLFLP GV~~~~~~LG
O57747_PYRHO FKLRKFLVKR ~~~~~~~~~~ ~~SYKFVPSL LFSWFFILLL PQV~~~~~LG
O60159_SCHPO FLIQKLRKKY ~~~~~~LSRW GVLDAAFVTV ITSLVS~FLN PWL~~~~~RL
O60958_LEIMA LHVGRWRKKH ~~~~~~LRQW RIVEVAVVAA VTGVVN~FLT PYG~~~~~SG
O94287_SCHPO MKFASKTKGF ~~~~~~SKIS NVFFVIFLSL ITSLTAYAIL GESEL~~~LF
P73745_SYNY3 FKVLDWFDRL ~~~~~~PPLA TKWKGFLLGS IIGILSLFPL PL~~~~~~TD
P74477_SYNY3 LSLQNWQRKQ ~~~~~~~NLS LVIRIGVVGL ISGVAIALLP SF~~~~~~FR
P93567_SOLTU ~~VDKVLRTY AVINERGPAF KILLVMSVSI LTSCCS~YGL PW~~~~~~FA
P96820_MYCTU HASVAITRRL ~~~~~~~PGG PVLKPAIGGL LVGLLG~LPI PQI~~~~~LS
Q17804_CAEEL IRWSRFRKNS KMLG~~~~GN PIYEVMLITL VTAAIS~YFN PFT~~~~~RK
Q18368_CAEEL RQISIFRSKN RVYKLIFRNN FLAFTVFMAF VVGVLT~FPN GLGRYFAGRL
Q22833_CAEEL RRIAFFKRKN RIFQALFGKS PILFTACCAA IFAVLV~YPN GLGSYVAGKY
Q9BHB2_CAEEL TKLTEFRKKY ~~~~VSSKLG RLFECLLVAA VSGFLA~FLT IFA~~~~~ID
Y305_METJA RKISSTFDNL ~~~~~~~KIP YCIKTLIGGI LVAVIS~YFI PEV~~~~~MG
Alignment XXXXXXXXXX XXXXYXXXXX XAAAAAAAAA AAAAAAAAXX XXXXXXXXXY
Domain DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD
Secondary HHHHHHHHHH HHHH.HHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHH.
FunctionalAA .......... .......... .......... .......... ..........

551 600
CICH_TORMA MPRETINSLF D~~~NYT~~~ ~~~~~~~~~~ ~WTKT~~I~D PRGLGNSA~~
CLCA_ARATH ECKPCDPSID E~~~ICP~TN GRSGNFKQ~~ FNCPNGY~YN DLSTLLLTTN
CLCA_ECOLI GGFNLIPIAT A~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
CLCD_ARATH KCSPCPESVP DSGIECPRPP GMYGNYVN~~ FFCKTDNEYN DLATIFFNTQ
CLCKA_HUMAN SMKQHLDSLF D~~~NHS~~~ ~~~~~~~~~~ ~WALM~~TQN SSPPWPEELD
CLCN1_RAT MPREAISTLF D~~~NNT~~~ ~~~~~~~~~~ ~WVKH~~IGD PKSLGQSA~~
CLCN2_HUMAN SQKETLVTLF D~~~NRT~~~ ~~~~~~~~~~ ~WVRQGLVEE LEPPSTSQ~~
CLCN3_RAT NTSELIKELF T~~~DCGPLE SS~~~~~~~~ SLCDYRNDMN ASKIVDDIPD
CLCN6_HUMAN ECRQMSSSSQ IGNDSFQLQV TEDVNSSIKT FFCPNDT~YN DMATLFFNPQ
CLCN7_RAT DCQPLQGSSM S~~~~~~~~~ ~~~~~~YPLQ LFCADGE~YN SMAAAFFNTP
GEF1_YEAST DMTESMGILF H~~~ECVKND NTSTFSHRLC QLDENTHA~~ ~~~~~~~~~~
O13080_XENLA SSSEMISELF N~~~DCGLLD SS~~~~~~~~ KLCDYVNDYN NTKGG~~NLP
O28857_ARCFU MGYGYVQMAI D~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O57747_PYRHO GGKLLLWSLM K~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O60159_SCHPO DMTLGMELLF Q~~~ECKSSS SP~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O60958_LEIMA SMLELLGDCF Q~~~DCTPSG TM~~~~~~~~ EMCED~~~~~ ~~~~~~~~~~
O94287_SCHPO NPMELFPQVI N~~~SCSPSS ST~~~~~~~~ VLCE~~~~~~ ~~~~~~~~~~
P73745_SYNY3 GGDNAVLWAF N~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
P74477_SYNY3 DNAGLREFVT S~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
P93567_SOLTU GCIPCPVGLE E~~~KCPTIG RS~GNYKN~~ FQCPAGH~YN DLASLFLNTN
P96820_MYCTU SGYGWAQLAA DRGTLLS~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Q17804_CAEEL SAQSMIQQLF D~~~RCEDQI DE~~~~~D~~ SLCD~~~~~~ ~~~~~~~~~Q
Q18368_CAEEL TFRETMADFF N~~~NCT~~~ ~~~~~~~~~~ ~W~VS~~~ND SRRCPDTILT
Q22833_CAEEL TFRETLVDFL S~~~NCT~~~ ~~~~~~~~~~ LWKQT~~~NG SEGCPPHMLE
Q9BHB2_CAEEL DCQPIGANPT A~~~TSTQIN QM~~~~~~~~ ~WCKKGE~YS AVASLFFQNP
Y305_METJA MGLTLTKELF I~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Alignment YYXXXXXXXX X......... .......... .......... ..........
Domain DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD
Secondary ..HHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH
FunctionalAA .......... .......... .......... .......... ..........

601 650
CICH_TORMA ~~~~~~QWF~ ~~IPHLNIFI VMALY~FVMH FWMAALAVTM PVPCGAFVPV
CLCA_ARATH DDAVRNIFSS NTPNEFGMVS LWIFF~~GLY CILGLITFGI ATPSGLFLPI
CLCA_ECOLI ~~~~~~~~~~ ~~~GNFSMGM LVFIF~~VAR VITTLLCFSS GAPGGIFAPM
CLCD_ARATH DDAIRNLFSA KTMREFSAQS LLTFL~~AMF YTLAVVTFGT AVPAGQFVPG
CLCKA_HUMAN PQHLWWEWY~ ~~HPRFTIFG TLAFF~LVMK FWMLILATTI PMPAGYFMPI
CLCN1_RAT ~~~~~~VWI~ ~~HPQVNVVI IILLF~FVMK FWMSIVATTM PIPCGGFMPV
CLCN2_HUMAN ~~~~~~AWN~ ~~PPRANVFL TLVIF~ILMK FWMSALATTI PVPCGAFMPV
CLCN3_RAT RPAGVGVY~~ ~~~SAIWQLC LALIF~~~~K IIMTVFTFGI KVPSGLFIPS
CLCN6_HUMAN ESAILQLFH~ Q~DGTFSPVT LALFF~~VLY FLLACWTYGI SVPSGLFVPS
CLCN7_RAT EKSVVSLFH~ DPPGSYNPMT LGLFT~~LVY FFLACWTYGL TVSAGVFIPS
GEF1_YEAST ~~~~~~~~~~ ~~~FEFLKIF TSLCFATVIR ALLVVVSYGA RVPAGIFVPS
O13080_XENLA DRAAGNGVY~ ~~~TAMWQLS LALIF~~~~K AVITIFTFGI KVPSGLFIPS
O28857_ARCFU ~~~~~~~~~~ ~~~GKLAVTV MLLLI~~FGK IVATSLTVGT GGSGGVFAPS
O57747_PYRHO ~~~~~~~~~~ ~~ESIVSLDI LILLL~~ILK SIHTLFSAAS DAPGGLFCPS
O60159_SCHPO ~~~~~ELINL CDPSLRTKNT ILLLIATFAR TIFVTFSYGA KVPAGIFVPS
O60958_LEIMA ~~~~~~~~~~ ~~~SDLRAFF SLLVT~ATAK FAMFAYTVGT FLPAGILVPS
O94287_SCHPO ~~~~~~~~~~ ~~~TTFWVTA IVLFTSALLG LLLTSATFGA AIPTGIIVPS
P73745_SYNY3 ~~~~~~~~~~ ~~~SQSHFST LILVF~~CGR FLLTLICYGS GAIGGIFAPM
P74477_SYNY3 ~~~~~~~~~~ ~~~GELSWHQ VVLTL~~VAH FILTILAYST DAPGGLFAPA
P93567_SOLTU DDAIRNLFSS NNSNEFHIST LLIFF~~AGV YCLGIITYGI AIPSGLFIPV
P96820_MYCTU ~~~~~~~~~~ ~~~IPLWIVI VLPIA~~~~K ILATSLSIGT GGSGGLFGPG
Q17804_CAEEL NKALSIAFG~ ~~~QLLW~~~ ~ALIF~~~~K FVITIFTFGI KVPCGLFVPS
Q18368_CAEEL ~~~~~~HWTG GSEGDVSIFT SLVLY~YILY FVLVAICISI NVPAGVFVPS
Q22833_CAEEL ~~~~~~HWS~ GPEGDMMPIN SLLIY~FLFY FIIVPICITL YIPSGIFVPC
Q9BHB2_CAEEL EESVKSMFH~ SPINSFGVTT LVIFG~~IEY FLLTLWTFGI SVPSGVFIPA
Y305_METJA ~~~~~~~~~~ ~~~MEFSLVF LVLLL~~IGK ILATSFTVGS GTPGGLVFPS
Alignment .......... ......XXXX AAAAXXXXXX XAAAAAAAAA AAAAAAAAAA
Domain DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD
Secondary HHHHHHHHHH HHHH..HHHH HHHHHHHHHH HHHHHHHHHH .....HHHHH
FunctionalAA .......... .......... .......... .......... ....MBBMM.

651 700
CICH_TORMA FNLGAVLGRF V~~~~~GELM ALL~~~~~~~ ~~FPDGLVSN GNLYHILPGE
CLCA_ARATH ILMGSAYGRM L~~~~~GTAM GSY~~~~~~~ ~~~~~~~~~~ ~~~TNIDQGL
CLCA_ECOLI LALGTVLGTA F~~~~~GMVA VEL~~~~~~~ ~~~~~~~~~~ FPQYHLEAGT
CLCD_ARATH IMIGSTYGRL V~~~~~GMFV VRF~~~~~~~ ~~~~~~~~~~ YKKLNIEEGT
CLCKA_HUMAN FILGAAIGRL L~~~~~GEAL AVA~~~~~~~ ~~FPEGIVTG GVTNPIMPGG
CLCN1_RAT FVLGAAFGRL V~~~~~GEIM AML~~~~~~~ ~~FPEGILFD DIIYKILPGG
CLCN2_HUMAN FVIGAAFGRL V~~~~~GESM AAW~~~~~~~ ~~FPDGIHTD SSTYRIVPGG
CLCN3_RAT MAIGAIAGRI V~~~~~GIAV EQL~~AYYHH DWFIFKEWCE VGADCITPGL
CLCN6_HUMAN LLCGAAFGRL V~~~~~ANVL KSY~~~~~~~ ~~~~~~~~~~ IGLGHIYSGT
CLCN7_RAT LLIGAAWGRL F~~~~~GISM SYL~~~~~~~ ~~~~~~~~~T GAAIWADPGK
GEF1_YEAST MAVGATFGRA V~~~~~SLLV ERF~~~~~~~ ~~~~~~~~~I SGPSVIIPGA
O13080_XENLA MAVGAIMGRL L~~~~~GVAM EQL~~SFYHH DWLIFRGWCN QGADCITPGL
O28857_ARCFU IVIGSMVGGF V~~~~~GYSF HYL~~~~~~~ ~~~~~~~~~~ FPNVIVQPEA
O57747_PYRHO LAMGAIIGSI L~~~~~GK~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~K
O60159_SCHPO MAVGASFGYM I~~~~~GLIA EMI~~~YQRF PNSVLFLACH GSESCITPGT
O60958_LEIMA LTIGALYGRA F~~~~~GMMF RAL~~~QETY ASSYIFTECY DQDLCVIPGV
O94287_SCHPO LAIGACIGRA V~~~~~GTLL KSR~~~~~~~ ~~~~~~~~~~ ~FPSLAGTSI
P73745_SYNY3 LGIASIVSVA M~~~~~ARHF HLL~~~~~~~ ~~~~~~~~~~ FPSQIPEPAV
P74477_SYNY3 LVMGSALGYL V~~~~~GEFG SYW~~~~~~~ ~~~~~~~~~~ ~~QDQVTQTT
P93567_SOLTU ILAGASYGRI F~~~~~GRAL GSL~~~~~~~ ~~~~~~~~~~ ~~~SNLNVGL
P96820_MYCTU IVIGAFVGAA I~~WRLGELT ELP~~~~~~~ ~~~~~~~~~~ ~~GVPHEPGI
Q17804_CAEEL IGMGAIAGRI L~~~~~GITV DQIFRAVQAT PGHSDYFTCQ IGKDCVMPGL
Q18368_CAEEL FIIGAAGGRL ITVFPVGETM VVL~~~~~~~ ~~FPEGMRGP GGP~PIHPGL
Q22833_CAEEL FVIGACGGRI F~~~~~GEII SMI~~~~~~~ ~~WPYGLRGL GQP~QIYPGL
Q9BHB2_CAEEL ILTGAAWGRL F~~~~~GIFV ERL~~~~~~~ ~~~~~~~~~F PSVTGIDPGK
Y305_METJA MCIGAISGII F~~~~~GSLI GDC~~~~~~~ ~~~~~~~~~~ ~~~~~~~SAP
Alignment AAAAAAAAAA A.....AAAA XXX....... .......... XXXXXAAAAA
Domain DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD
Secondary HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHH.HHHH
FunctionalAA .......... .......... .......... .......... ..........

701 750
CICH_TORMA YAVIGAAAMT GAVTH~AVST AVICFELTGQ ISHVLPMMVA VILANMVAQG
CLCA_ARATH YAVLGAASLM AGSMRMTVSL CVIFLELTNN LLLLPITMFV LLIAKTVGDS
CLCA_ECOLI FAIAGMGALL AASIRAPLTG IILVLEMTDN YQLILPMIIT GLGATLLAQF
CLCD_ARATH YALLGAASFL GGSMRMTVSL CVIMVEITNN LKLLPLIMLV LLISKAVGDA
CLCKA_HUMAN YALAGAAAFS GAVTH~TIST ALLAFELTGQ IVHALPVLMA VLAANAIAQS
CLCN1_RAT YAVIGAAALT GAVSH~TVST AVICFELTGQ IAHILPMMVA VILANMVAQS
CLCN2_HUMAN YAVVGAAALA GAVTH~TVST AVIVFELTGQ IAHILPVMIA VILANAVAQS
CLCN3_RAT YAMVGAAACL GGVTRMTVSL VVIVFELTGG LEYIVPLMAA VMTSKWVGDA
CLCN6_HUMAN FALIGAAAFL GGVVRMTISL TVILIESTNE ITYGLPIMVT LMVAKWTGDF
CLCN7_RAT YALMGAAAQL GGIVRMTLSL TVIMMEATSN VTYGFPIMLV LMTAKIVGDV
GEF1_YEAST YAFLGAAATL SGITNLTLTV VVIMFELTGA FMYIIPLMIV VAITRIILST
O13080_XENLA YAMVGAAACL GGATRMTVSL VVIMFEITGG LEYIVPLMSA AMTSKWVADA
O28857_ARCFU FVLIGMSAFV AAVAKTPIAA ILMVLEMCGG YSLLPALMTA ATLAYYLAGD
O57747_PYRHO FVVPGMVGVL AGVYKAPLTP ILLMFETGVT PKVIPGLLLS SLISYLITIK
O60159_SCHPO YALLGAAASL SGIMHLTVTI VVIMFELTGA LNFILPTVLV VALANSIGNM
O60958_LEIMA YAIVGAAAML TGVTHMTICL AIIMFELTGS LEYMVPVIVG ILCAKAAGEA
O94287_SCHPO YGVIGSIAFL SSTTRLVVAL VVILFELTGA LNIALPLMLA TLISKWVSDS
P73745_SYNY3 MAIAGMGALV AATVRAPLTA ILLTIEMTDN YFVILPLLVT CLVASVVAEA
P74477_SYNY3 FALAGMGAFF TSVVRVPVTA IIIVFELTGN FNVVLPLMVA CATSYLVAES
P93567_SOLTU FSLLGAASFL GGTMRMTVSI CVILLELTNN LLMLPLVMLV LLISKTVADI
P96820_MYCTU FVVVAMMACF GSVSRAPLAV MIMVAEMTGS FSVVPGAIIA VGIAALLLRS
Q17804_CAEEL YAMVGAAAVL GGVTRMTVSL VVIMFELTGS LEFIVPTMVA TMFSKWIGDG
Q18368_CAEEL YAVVGAAAYT GAVTH~TLSV SVIICELTGQ LSPILPVLIA MLMGNAVCKF
Q22833_CAEEL YAVVGAASFT GSVTH~SLSI ALIVCETTGQ LCALLPVLIA LMISNAICAF
Q9BHB2_CAEEL YALAGAAAQL GGVVRMTISL TAIIMEATKD ITFGLPIMLV LMVTKWVGDM
Y305_METJA YIVLGIATTL SATTNAPLGG AVLCTEIFGF DFAVPASIGA VIGY.~~~~~
Alignment AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAXXX
Domain DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD DDDDDDDDDD
Secondary HHHHHHHHHH HHH..HHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH
FunctionalAA .......... .......... .......... .......... ..........

751 800
CICH_TORMA LQ..PSLYDS IIQIKKLPYL PELSWSSANK YNIQVGD~~~ ~~~~~~~~~~
CLCA_ARATH FN..LSIYEI ILHLKGLPFL EANPEPWMRN LTVGELN~~~ ~~~~~~~~~~
CLCA_ECOLI TG~GKPLYSA I~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
CLCD_ARATH FN..EGLYEV QARLKGIPLL ESRPKYHMRQ MIAKEA~~~~ ~~~~~~~~~~
CLCKA_HUMAN CQ..PSFYDG TIIVKKLPYL PRILGRNIGS HHVRVEH~~~ ~~~~~~~~~~
CLCN1_RAT LQ..PSLYDS IIQVKKLPYL PDLGWNQLSK FTIFVED~~~ ~~~~~~~~~~
CLCN2_HUMAN LQ..PSLYDS IIRIKKLPYL PELGWGRHQQ YRVRVED~~~ ~~~~~~~~~~
CLCN3_RAT FG~REGIYEA HIRLNGYPFL DAKEEFTHTT LAADVMRP~~ ~~~~~~~~~~
CLCN6_HUMAN FN..KGIYDI HVGLRGVPLL EWETEVEMDK LRASD~~~~~ ~~~~~~~~~~
CLCN7_RAT FI..EGLYDM HIQLQSVPFL HWEAPVTSHS LTARE~~~~~ ~~~~~~~~~~
GEF1_YEAST SGISGGIADQ MIMVNGFPYL EDEQDEEEEE TLEKYTAEQ~ ~~~~~~~~~~
O13080_XENLA LG~RGSIYDA HIHLNGYPFL EAKGEFSHKT LAMDVMRP~~ ~~~~~~~~~~
O28857_ARCFU YS....IYAE QVATRAESPA HRMEMSIDVL ENVRVQDAM~ ~~~~~~~~~~
O57747_PYRHO TL~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O60159_SCHPO LG~KTGIADR SIEINGLPLL EPEKSINSSN TINIPITE~~ ~~~~~~~~~~
O60958_LEIMA VG~VKGTYEI GIEENKLPYL DPKKEFYLDF VAKDVYGN~~ ~~~~~~~~~~
O94287_SCHPO II~ETSIYDA WIQFRNIPYF PSSNSLKFSI PLNFPVR~~~ ~~~~~~~~~~
P73745_SYNY3 LG~GKPIYTV L~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
P74477_SYNY3 LF~PRSLYDH LLETKGIFLA EEKPDHDFLA DIRAGQ~~~~ ~~~~~~~~~~
P93567_SOLTU FN..KGVYDQ IVKMKGLPFL EAHAEPFMRN LVAGD~~~~~ ~~~~~~~~~~
P96820_MYCTU TN~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Q17804_CAEEL IS~KMGIYEA HIELNGYPFL DSKGEYPYST VASQVMRPSI HRQVADEMSM
Q18368_CAEEL LQ..PSIYES IIRVKKYPYL PDLPPSRVSV HTVKVEQ~~~ ~~~~~~~~~~
Q22833_CAEEL LQ..PSIYDS IIKINGYPYL ADLPPSRMSV HQMKVER~~~ ~~~~~~~~~~
Q9BHB2_CAEEL FN..EGLYDA HIDLAEVPIL GWNPPKMSRN ILADR~~~~~ ~~~~~~~~~~
Y305_METJA ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Alignment .....XXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXX... ..........
Domain DD........ .......... .......... .......... ..........
Secondary .....HHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH
FunctionalAA .......B.. .......... .......... .......... ..........

801 850
CICH_TORMA ~~~~~IMVRD VTSIASTSTY GDLLHVLRQT ~~KL~~KFFP FV~~~~~~~~
CLCA_ARATH ~~~~~DAKPP VVTLNGVEKV ANIVDVLRNT ~~TH~~NAFP VL~~~~~~~~
CLCA_ECOLI ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
CLCD_ARATH ~~~~~CQSQK VISLPRVIRV ADVASILGSN ~~KH~~NGFP VI~~~~~~~~
CLCKA_HUMAN ~~~~~FMNHS ITTLAKDTPL EEVVKVVTST ~~DV~~TEYP LV~~~~~~~~
CLCN1_RAT ~~~~~IMVRD VKFVSASCTY GELRNLLQTT ~~TV~~KTLP LV~~~~~~~~
CLCN2_HUMAN ~~~~~IMVRD VPHVALSCTF RDLRLALHRT ~~KG~~RMLA LV~~~~~~~~
CLCN3_RAT ~~~RRSDPPL AVLTQDNMTV DDIENMINET ~~SY~~NGFP VI~~~~~~~~
CLCN6_HUMAN ~~~~~IMEPN LTYVYPHTRI QSLVSILRTT ~~VH~~HAFP VV~~~~~~~~
CLCN7_RAT ~~~~~VMSTP VTCLRRREKV GIIVDVLSDT ASNH~~NGFP VV~~~~~~~~
GEF1_YEAST ~~~~~LMSSK LITINETIYL SELESLLYDS ASEYSVHGFP IT~~~~~~~~
O13080_XENLA ~~~RRNDPIL TAITQDSMTV EDIEAIISET ~~TY~~SGFP IV~~~~~~~~
O28857_ARCFU ~~~~~VSADK LVVVTPYQRV SEVLELIEKT ~~GH~~MGFP VV~~~~~~~~
O57747_PYRHO ~~~~~~~~~~ ~~~~~~~~~~ ~~~....KTE ~~~~~~~~~~ ~~~~~~~~~~
O60159_SCHPO ~~~~VMASNL ITIPSIGFTW RKLLGMMEGY ~~DF~~SGYP VV~~~~~~~~
O60958_LEIMA ~~~~~~~KQF TVLTAYGLQV RDINELVTKM ~~NV~~TGFP VV~~~~~~~~
O94287_SCHPO ~~~~~SPEQL VRLPIRSCSI EELERAMHDS ~~~S~~QSFF VV~~~~~~~~
P73745_SYNY3 ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
P74477_SYNY3 ~~~~~VMKTE VESLEQSLTL AQVLPIMSNS ~~HH~~RGFP VVQGGKLVGV
P93567_SOLTU ~~~~~VCSGP LLSFSGVEKV GNIVHALKYT ~~RH~~NGFP VI~~~~~~~~
P96820_MYCTU ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Q17804_CAEEL SDLRELKNEL SVITESGMTL GDLESLLRQT ~~DF~~NGFP VV~~~~~~~~
Q18368_CAEEL ~~~~~LMVTD VIYITKDMTY REMKEILQLA ~PHL~~RSFP IV~~~~~~~~
Q22833_CAEEL ~~~~~IMVKD IFYITRETTY RELREMLLES ~PTL~~RSYP FV~~~~~~~~
Q9BHB2_CAEEL ~~~~~VMRKD VVALERRERV SRIVEILRST ~~LH~~HGFP VV~~~~~~~~
Y305_METJA ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Alignment .......... .......... ..XXXXXXXX XXXXXXXXXX XX........
Domain .......... .......... .......... .......... ..........
Secondary HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH
FunctionalAA .......... .......... .......... .......... ..........

851 900
CICH_TORMA ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~DT PDTNT~~~~~ ~~~~~~~~~~
CLCA_ARATH ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~DG ADQNTGTE~~ ~~~~~~~~~~
CLCA_ECOLI ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
CLCD_ARATH ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~DH TRSGETL~~~ ~~~~~~~~~~
CLCKA_HUMAN ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~ES TE~~~~SQI~ ~~~~~~~~~~
CLCN1_RAT ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~DS KD~~~~SMI~ ~~~~~~~~~~
CLCN2_HUMAN ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~ES PESMI~~~~~ ~~~~~~~~~~
CLCN3_RAT ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~MS KE~~~~SQR~ ~~~~~~~~~~
CLCN6_HUMAN ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~TE NRGNEKEFMK GNQ~~~~~~~
CLCN7_RAT ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~ED VGDTQPAR~~ ~~~~~~~~~~
GEF1_YEAST ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~KD EDKFEKEKR~ ~~~~~~~~~~
O13080_XENLA ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~VS RE~~~~SQR~ ~~~~~~~~~~
O28857_ARCFU ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~MD GR~~~~~~~~ ~~~~~~~~~~
O57747_PYRHO ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O60159_SCHPO ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~LD SR~~~~SNY~ ~~~~~~~~~~
O60958_LEIMA ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~ES LS~~~~DVT~ ~~~~~~~~~~
O94287_SCHPO ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~LK ND~~~~TEF~ ~~~~~~~~~~
P73745_SYNY3 ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
P74477_SYNY3 FTQTDLANAA QESVHIALKQ IMTPNPITVD PEAPLSDVLY LLNRYQLSRL
P93567_SOLTU ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~DE PPFSETPE~~ ~~~~~~~~~~
P96820_MYCTU ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Q17804_CAEEL ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~VS QN~~~~SMH~ ~~~~~~~~~~
Q18368_CAEEL ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~TD HE~~~~NKI~ ~~~~~~~~~~
Q22833_CAEEL ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~TD SR~~~~SMT~ ~~~~~~~~~~
Q9BHB2_CAEEL ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~DR IEESPYESLP DYGR~~~~~~
Y305_METJA ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Alignment .......... .......... .......... .......... ..........
Domain .......... .......... .......... .......... ..........
Secondary HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH
FunctionalAA .......... .......... .......... .......... ..........

901 950
CICH_TORMA ~~~~~~~~LL GSIDRTEVE~ ~GLLQRRISA YRRQPAAAAE ADEEGRNGET
CLCA_ARATH ~~~~~~~~LH GLILRAHLV~ ~KVLKKRWFL NEKRRTEE~~ ~~~~~~~~~~
CLCA_ECOLI ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
CLCD_ARATH ~~~~~~~~VI GLVLRSHLL~ ~VLLQSKVDF QHSPLPCDPS ARN~~~~~~~
CLCKA_HUMAN ~~~~~~~~LV GIVQRAQLV~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
CLCN1_RAT ~~~~~~~~LL GSVERSELQ~ ~SLLQRHLCA ERRLKAAQDM ARKLSELPYN
CLCN2_HUMAN ~~~~~~~~LL GSIERSQVV~ ~ALLGAQLSP ARRRQHMQER RATQTSPLSD
CLCN3_RAT ~~~~~~~~LV GFALRRDLT~ ~IAIESARK~ ~~~~~~~~~~ ~~~~~~~~~~
CLCN6_HUMAN ~~~~~~~~LI SNNIKFKKS~ ~SILTRAGEQ RKRSQSMKSY PSSELRNMCD
CLCN7_RAT ~~~~~~~~LQ GLILRSQLI~ ~VLLKHKVFV ERS~~~~~~~ ~~~~~~~~~~
GEF1_YEAST ~~~~~~~~CI GYVLKRHLAS KIMMQ~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O13080_XENLA ~~~~~~~~LM GFVLRRDLI~ ~ISIESARK~ ~~~~~~~~~~ ~~~~~~~~~~
O28857_ARCFU ~~~~~~~~LV GMVTFEDVE~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O57747_PYRHO ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O60159_SCHPO ~~~~~~~~LI GYLKKSSLK~ ~SSFE~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O60958_LEIMA ~~~~~~~~LL GYAPVKKIV~ ~RALQ~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O94287_SCHPO ~~~~~~~~FE GFISRNKVS~ ~ELLN~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
P73745_SYNY3 ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
P74477_SYNY3 PVVEGDNKLV GIITRTDIIR EEVSQLGGQI IHPPHPAYSV YQTRSPLVGE
P93567_SOLTU ~~~~~~~~LC GLVLRSHLL~ ~VLLNGKKFT KQRVLSASNI L~~~~~~~~~
P96820_MYCTU ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Q17804_CAEEL ~~~~~~~~LV GFITRRDIL~ ~LALHTARK~ ~~~~~~~~~~ ~~~~~~~~~~
Q18368_CAEEL ~~~~~~~~LL GSVAKRYLT~ ~MLLRRHVLV NQQ~~DSRNI GRMTPSEIFN
Q22833_CAEEL ~~~~~~~~LL GSVARKYLL~ ~YLIQRKLGP EPELFGHRRR SR~TASEIFS
Q9BHB2_CAEEL ~~~~~~~~LK GYILRSQLF~ ~KLLENRIFE EEGASNS~~~ ~~~~~~~~~~
Y305_METJA ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Alignment ........XX XXXXXXXXXX XXXX...... .......... ..........
Domain .......... .......... .......... .......... ..........
Secondary HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH
FunctionalAA .......... .......... .......... .......... ..........

951 1000
CICH_TORMA GASFTGEAES SFAYIDQEDA EGQQREGLEA VKVQTEDPRP PSPVPAEEPT
CLCA_ARATH ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
CLCA_ECOLI ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
CLCD_ARATH ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
CLCKA_HUMAN ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
CLCN1_RAT GQAQLAGEWH PGGRPESFAF VDEDEDE~~~ ~~DVSRKTEL PQTPTPPPPP
CLCN2_HUMAN QEGPPSPEAS VCFQVNTEDS AFPAARGETH KPLKPALKRG PSVTRNLGES
CLCN3_RAT ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
CLCN6_HUMAN EHIASEEPAE KEDLLQQMLE RRYTPYPNLY PDQSPSEDWT MEERFRPLTF
CLCN7_RAT ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
GEF1_YEAST ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O13080_XENLA ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O28857_ARCFU ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O57747_PYRHO ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O60159_SCHPO ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O60958_LEIMA ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O94287_SCHPO ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
P73745_SYNY3 ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
P74477_SYNY3 GRILLPIRDS DSALVLFQIA AAIAKKQNYE IDCLQVVKVS KAQSPSVQRV
P93567_SOLTU ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
P96820_MYCTU ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Q17804_CAEEL ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Q18368_CAEEL TIRRTSMRLS RRSPSRRSNS SQTRENSVPE TARSDAPSDQ VEFVSERTIS
Q22833_CAEEL TINNLR~KYS RRGSLAANGA HMSSGNA~~~ ~~~~~~~~~~ ~~LMTDRNIS
Q9BHB2_CAEEL ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Y305_METJA ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Alignment .......... .......... .......... .......... ..........
Domain .......... .......... .......... .......... ..........
Secondary HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH
FunctionalAA .......... .......... .......... .......... ..........

1001 1050
CICH_TORMA QTSGIYQK~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
CLCA_ARATH ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
CLCA_ECOLI ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
CLCD_ARATH ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
CLCKA_HUMAN ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
CLCN1_RAT PPPLPPQFPI APSYPEEPNG PLPSHKQPPE ASDSADQRSS IFQRLLHCLL
CLCN2_HUMAN PTGSAESAGI A~~~~~~~~~ ~~~~~~~~LR SLFCGSPPPE AASEKLESCE
CLCN3_RAT ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
CLCN6_HUMAN HGLILRSQLV T~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~L LVRGVCYSES
CLCN7_RAT ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
GEF1_YEAST ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O13080_XENLA ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O28857_ARCFU ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O57747_PYRHO ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O60159_SCHPO ~~~~~~~AA~ K~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O60958_LEIMA ~~~~~~~VAA A~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O94287_SCHPO ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
P73745_SYNY3 ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
P74477_SYNY3 QWQRQRQLMQ K~~~~~~~~~ ~~~~~~~~~~ ~~~~LERIAR HQRVLFHTEI
P93567_SOLTU ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
P96820_MYCTU ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Q17804_CAEEL ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Q18368_CAEEL GNTLLSISPL H~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Q22833_CAEEL GNTLLPQSPL H~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Q9BHB2_CAEEL ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Y305_METJA ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Alignment .......... .......... .......... .......... ..........
Domain .......... .......... .......... .......... ..........
Secondary HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH
FunctionalAA .......... .......... .......... .......... ..........

1051 1100
CICH_TORMA ~~~~~KQKGT GQVASRFEEM LTLEEIYRWE QREKNVVVNF ~~ETCRIDQS
CLCA_ARATH ~~~~~WEVRE KFTPVELAER EDNFDDVAIT SSEMQLYVDL ~~HPL~TNTT
CLCA_ECOLI ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
CLCD_ARATH ~~~~~IRHSF SEFAKPVSSK GLCIEDIHLT SDDLEMYIDL ~~APF~LNPS
CLCKA_HUMAN ~~~~~~~~~~ ~~~~~~~~~Q ALQAEPPSRA PGHQQCLQDI LARGCPTEPV
CLCN1_RAT GKAHSTKKKI TQDSTDLVDN MSPEEIEAWE REQLSQPVCF ~~DFCCIDQS
CLCN2_HUMAN KRKLKRVRIS LASDADLEGE MSPEEILEWE EQQLDEPVNF ~~SDCKIDPA
CLCN3_RAT ~~~~~KQEGV VGSSRVCFAQ ~~~~~HTPSL PAESPRPLKL ~~RSI~LDMS
CLCN6_HUMAN QSSASQPRLS YAEMAEDYPR YPDIHDLDLT LLNPRMIVDV ~~TPY~MNPS
CLCN7_RAT NMGLVQRRLR LKDFRDAYPR FPPIQSIHVS QDERECTMDL ~~SEF~MNPS
GEF1_YEAST ~~~~~~~~~~ SVNSTKAQTT LVYFNKSNEE LGHRENCIGF ~~KDI~MNES
O13080_XENLA ~~~~~KQEGI VSTSRIYFTE ~~~~~HTPTQ PTTAPPSLKL ~~RAI~MDLS
O28857_ARCFU ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~RVPLE ERDKKLVRDI ~~~~~~MTRE
O57747_PYRHO ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O60159_SCHPO ~~~~~LEPSF TFDQQLCFGK VDSVGDSKSS KFGESDRIDL ~~SAY~MDVN
O60958_LEIMA ~~~~~RNSDM NLNTYIRFKT ~~~~~KPSHS RDATFLEVDL ~~TGI~LESC
O94287_SCHPO ~~~~~RRPMS SNMQTTDNTG ~~~LDPLRSA SAPVDSTFDL ~~FDY~IHPT
P73745_SYNY3 ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~LERT
P74477_SYNY3 KLAYSITDTI LDTIQTRHSD LLILEWQGEM PIGGQIFGQI ~~TDRLIDQA
P93567_SOLTU ~~~~~SRFHA FDFAKPGSGK GLKFEDLVIT EEEMEMYIDL ~~HPI~TNTS
P96820_MYCTU ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~....
Q17804_CAEEL ~~~~~TQPYV VTNSIAYFSD ~~~~~GVPDA MPGGPAPLRL ~~RKI~LDMA
Q18368_CAEEL CP~~NNIPLQ AVFTRPSSAD ~~LSKTETNA DILLNRNIDL ~~DEIAIDAA
Q22833_CAEEL EDQGDRSPLA PLLYAQTNQH EPIVHSLAKR AEILSKKLDM ~~EEVAIDPA
Q9BHB2_CAEEL ~~~~~ALPND FYECQDDDDQ MKSVAELGLT NFDESCFLDI ~~EPY~MHPH
Y305_METJA ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Alignment .......... .......... .......... .......XXX XXXXXXXX..
Domain .......... .......... .......... .......... ..........
Secondary HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH
FunctionalAA .......... .......... .......... .......... ..........

1101 1150
CICH_TORMA PFQLVEGTSL QKTHTLFSLL GLDRAYVTSM ~~~~~~GKLV GVVALAEIQA
CLCA_ARATH PYTVVQSMSV AKALVLFRSV GLRHLLVVPK IQASGMSPVI GILTRQDLR~
CLCA_ECOLI ~~~LARTLAK QEAEQLARSK AASASENT~~ ~~~~~~~~~~ ~~~~~~~~~~
CLCD_ARATH PYVVPEDMSL TKVYNLFRQL GLRHLFVVPR ~~~~~PSRVI GLITRKDLLI
CLCKA_HUMAN TLTLFSETTL HQAQNLFKLL NLQSLFVTSR ~~~~~~GRAV GCVSWVEMK~
CLCN1_RAT PFQLVEQTTL HKTHTLFSLL GLHLAYVTSM ~~~~~~GKLR GVLALEELQK
CLCN2_HUMAN PFQLVERTSL HKTHTIFSLL GVDHAYVTSI ~~~~~~GRLI GIVTLKELRK
CLCN3_RAT PFTVTDHTPM EIVVDVFRKL GLRQCLVTHN ~~~~~~GRLL GIITKKDIL~
CLCN6_HUMAN PFTVSPNTHV SQVFNLFRTM GLRHLPVVNA ~~~~~VGEIV GIITRHNLTY
CLCN7_RAT PYTVPQEASL PRVFKLFRAL GLRHLVVVDN ~~~~~HNQVV GLVTRKDLA~
GEF1_YEAST PISVKKAVPV TLLFRMFKEL GCKTIIVEES ~~~~~~GILK GLVTAKDILR
O13080_XENLA PFTITDQTPM EIVVDIFRKL GLRQCLVTHN ~~~~~~GRLL GIITKKDVL~
O28857_ARCFU LIVTYPDETL EEALIKLVDK GIGRLPVVDR ~~~NDEKKLL GIITRSDIMK
O57747_PYRHO ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O60159_SCHPO PISVLHTQSI ANVAVLFEVL SPSVIFIEKD ~~~~~~GNLV GLISKKDLLL
O60958_LEIMA LLQVEPECSV KKLLYLFKSL GTHHIFVCRY ~~~~~~SKFE GFISKKDFI~
O94287_SCHPO TFTLNYDTPP VLMLKLFKDA GITNLALLNH ~~~~~~GKLH GVLTK~~IV~
P73745_SYNY3 LAKQNRG~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
P74477_SYNY3 PCSLLMVKQG TNDHAYPRYL SPMAHWLMPV AGGPNIEKML NLLPALFSLY
P93567_SOLTU PYTVVETMSL AKAAILFRQL GLRHLCVVPK ~~KTGRAPIV GILTRHDFM~
P96820_MYCTU .VTIYETQRL NRQTAEAERG GSDRPTTA~~ ~~~~~~~~~~ ~~~~~~~~~~
Q17804_CAEEL PMTVTDQTPM ETVIDMFRKL GLRHVLVTKN ~~~~~~GKVL GIITKKDIL~
Q18368_CAEEL PFQLVLGSSL YKVHTLFSLL GLSHAYVTDC ~~~~~~GKLV GVVGLKELRD
Q22833_CAEEL PFQLVRGTSL YKVHTLFSLL ALNHAYVTEK ~~~~~~GRLC GVVAVKELRE
Q9BHB2_CAEEL PHRVPLNTSL PFIFRLFRGL GLRYLFVVND ~~~~~DNHLR GVITRKDVAR
Y305_METJA ~~~~~~~~QM TKLETIFKYI RF~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Alignment AAAAXXXXXA XXXX.AAAAA AAAAAAALLL LLLLLLLLAA AAAAAAAA..
Domain .......... .......... .......... .......... ..........
Secondary HHHHHHHHHH HHHH...... .......... .......... ..........
FunctionalAA .......... .......... .......... .......... ..........

1151 1200
CICH_TORMA AIEGSYQKGF RLPPPLASFR DVKHARNSGR TATSNSSGK~ ~~~~~~~~~~
CLCA_ARATH ~~~~AYNILQ AFPHLDKHKS GKAR~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
CLCA_ECOLI ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
CLCD_ARATH EENGESSAVE LQQSTSVRGR YSETATRMDA ARPLLDDLLG ~~~~~~~~~~
CLCKA_HUMAN ~~~~KAISNL TNPPAPK~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
CLCN1_RAT AIKGHTKSGV QLRPPLASFR NTTSIRKTPG GPPPPAESWN VPEGEDGAPE
CLCN2_HUMAN AIEGSVTAQG VKVRPPLASF RDSATSSSDT ETTEVHALWG PHSRHGLPRE
CLCN3_RAT ~~RHMAQTAN QDP~~~~~~~ ASIMFN~~~~ ~~~~~~~~~~ ~~~~~~~~~~
CLCN6_HUMAN EFLQARLRQH YQTI~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
CLCN7_RAT ~~RYRLGKGG LEELSLAQT~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
GEF1_YEAST FKRIKYREVH GAKFTYNEAL DRRCWSVIHF IIKRFTTNRN GNVI~~~~~~
O13080_XENLA ~~KHIAQMAN QDP~~~~~~~ DSILFN~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O28857_ARCFU AHAREVKRIV S~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O57747_PYRHO ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O60159_SCHPO ASKYYQEDND LVN~~~~~~~ PANRHRAVST ERIN~~~~~~ ~~~~~~~~~~
O60958_LEIMA ~~NFMRVKER EENMEDDELE RERRERVQQG RHHE~~~~~~ ~~~~~~~~~~
O94287_SCHPO ~~~~CFICTI ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
P73745_SYNY3 ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
P74477_SYNY3 PEENNPQLLI SKVYLPRQSQ RYDPFYDLKN LAERWSEQLQ RPIIPIPVCS
P93567_SOLTU ~~~~HEHISN LYPHLVPHK~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
P96820_MYCTU ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Q17804_CAEEL ~~QFMRNKNS Q~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Q18368_CAEEL AMANIYVRGA VAPVKPDRKL TSGTFLDMSH MNKD~~~~~~ ~~~~~~~~~~
Q22833_CAEEL ALSNIYSRGA VV~~~PKQRI RTSTFRLNPE QDLD~~~~~~ ~~~~~~~~~~
Q9BHB2_CAEEL FRERRRNREY HVDELYISES ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Y305_METJA ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Alignment .......... .......... .......... .......... ..........
Domain .......... .......... .......... .......... ..........
Secondary .......... .......... .......... .......... ..........
FunctionalAA .......... .......... .......... .......... ..........

1201 1250
CICH_TORMA ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
CLCA_ARATH ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
CLCA_ECOLI ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
CLCD_ARATH ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
CLCKA_HUMAN ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
CLCN1_RAT REVMVPTMPE TPVPPPSPEV PSCLAPARVE GELEELEMVG NLGPEEDLAD
CLCN2_HUMAN GSPSDSDDKC Q~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
CLCN3_RAT ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
CLCN6_HUMAN ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
CLCN7_RAT ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
GEF1_YEAST ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O13080_XENLA ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O28857_ARCFU ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O57747_PYRHO ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O60159_SCHPO ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O60958_LEIMA ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
O94287_SCHPO ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
P73745_SYNY3 ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
P74477_SYNY3 TSIADALSDL AEMRECAAIV LGASREGLLK NVIHGNLPTQ IASQTNTTVF
P93567_SOLTU ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
P96820_MYCTU ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Q17804_CAEEL ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Q18368_CAEEL ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~KLLN TPQTPPANGL
Q22833_CAEEL ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~RELQ NGHTAEPNGA
Q9BHB2_CAEEL ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Y305_METJA ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Alignment .......... .......... .......... .......... ..........
Domain .......... .......... .......... .......... ..........
Secondary .......... .......... .......... .......... ..........
FunctionalAA .......... .......... .......... .......... ..........

1251 1276
CICH_TORMA ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~
CLCA_ARATH ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~
CLCA_ECOLI ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~
CLCD_ARATH ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~
CLCKA_HUMAN ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~
CLCN1_RAT ILHGPSLRST DEEDEDELIL ~~~~~~
CLCN2_HUMAN ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~
CLCN3_RAT ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~
CLCN6_HUMAN ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~
CLCN7_RAT ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~
GEF1_YEAST ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~
O13080_XENLA ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~
O28857_ARCFU ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~
O57747_PYRHO ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~
O60159_SCHPO ~~~~~~DSYE NIELKPLKLN IE~~~~
O60958_LEIMA ~~~~~~AATA AVDVAPVAAR YN~~~~
O94287_SCHPO ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~
P73745_SYNY3 ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~
P74477_SYNY3 IFRGPVDSPN EEAIVPPLAP DFGLDE
P93567_SOLTU ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~
P96820_MYCTU ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~
Q17804_CAEEL ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~
Q18368_CAEEL SINMESPKFG NSLTVPPMAL ~~~~~~
Q22833_CAEEL PIR~~QPRV~ ~TIDVPENAK TDDETR
Q9BHB2_CAEEL ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~
Y305_METJA ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~
Alignment .......... .......... ......
Domain .......... .......... ......
Secondary .......... .......... ......
FunctionalAA .......... .......... ......