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ID TBRG4_HUMAN Reviewed; 631 AA.
AC Q969Z0; O14710; Q53GI8; Q8NDM4; Q9BUC6; Q9Y2F6;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 10-FEB-2009, entry version 50.
DE RecName: Full=Protein TBRG4;
DE AltName: Full=Transforming growth factor beta regulator 4;
DE AltName: Full=Cell cycle progression restoration protein 2;
DE Short=Cell cycle progression protein 2;
DE AltName: Full=FAST kinase domain-containing protein 4;
GN Name=TBRG4; Synonyms=CPR2, FASTKD4, KIAA0948;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX MEDLINE=99246063; PubMed=10231032; DOI=10.1093/dnares/6.1.63;
RA Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M.,
RA Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XIII.
RT The complete sequences of 100 new cDNA clones from brain which code
RT for large proteins in vitro.";
RL DNA Res. 6:63-70(1999).
RN [2]
RP SEQUENCE REVISION.
RA Ohara O., Nagase T., Kikuno R.;
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS
RP SER-22 AND LEU-57.
RC TISSUE=Mammary cancer;
RG The German cDNA consortium;
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Kidney;
RA Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lung, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 172-615 (ISOFORM 1), AND FUNCTION.
RC TISSUE=Hepatoma;
RX MEDLINE=98043401; PubMed=9383053;
RA Edwards M.C., Liegeois N., Horecka J., DePinho R.A., Sprague G.F. Jr.,
RA Tyers M., Elledge S.J.;
RT "Human CPR (cell cycle progression restoration) genes impart a Far-
RT phenotype on yeast cells.";
RL Genetics 147:1063-1076(1997).
RN [7]
RP TISSUE SPECIFICITY.
RC TISSUE=Lung;
RX MEDLINE=22642486; PubMed=12759187; DOI=10.1016/S0167-4781(03)00051-4;
RA Rival-Gervier S., Thepot D., Jolivet G., Houdebine L.-M.;
RT "Pig whey acidic protein gene is surrounded by two ubiquitously
RT expressed genes.";
RL Biochim. Biophys. Acta 1627:7-14(2003).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-65, AND MASS
RP SPECTROMETRY.
RC TISSUE=Epithelium;
RX PubMed=16964243; DOI=10.1038/nbt1240;
RA Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
RT "A probability-based approach for high-throughput protein
RT phosphorylation analysis and site localization.";
RL Nat. Biotechnol. 24:1285-1292(2006).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-553, AND MASS
RP SPECTROMETRY.
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of
RT the kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY.
RA Colinge J., Superti-Furga G., Bennett K.L.;
RL Submitted (OCT-2008) to UniProtKB.
CC -!- FUNCTION: May play a role in cell cycle progression.
CC -!- INTERACTION:
CC O43150:DDEF2; NbExp=1; IntAct=EBI-702328, EBI-310968;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q969Z0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q969Z0-2; Sequence=VSP_022460;
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC -!- SIMILARITY: Belongs to the FAST kinase family.
CC -!- SIMILARITY: Contains 1 RAP domain.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB69312.1; Type=Frameshift; Positions=211, 479, 498, 576;
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DR EMBL; AB023165; BAA76792.2; ALT_INIT; mRNA.
DR EMBL; AL833840; CAD38700.1; -; mRNA.
DR EMBL; AK222943; BAD96663.1; -; mRNA.
DR EMBL; BC002732; AAH02732.2; -; mRNA.
DR EMBL; BC014918; AAH14918.1; -; mRNA.
DR EMBL; BC017235; AAH17235.1; -; mRNA.
DR EMBL; AF011792; AAB69312.1; ALT_FRAME; mRNA.
DR IPI; IPI00329625; -.
DR IPI; IPI00477123; -.
DR RefSeq; NP_004740.2; -.
DR RefSeq; NP_112162.1; -.
DR UniGene; Hs.231411; -.
DR IntAct; Q969Z0; 5.
DR PhosphoSite; Q969Z0; -.
DR PeptideAtlas; Q969Z0; -.
DR PRIDE; Q969Z0; -.
DR Ensembl; ENSG00000136270; Homo sapiens.
DR GeneID; 9238; -.
DR KEGG; hsa:9238; -.
DR GeneCards; GC07M045103; -.
DR HGNC; HGNC:17443; TBRG4.
DR MIM; 611325; gene.
DR PharmGKB; PA134882196; -.
DR HOVERGEN; Q969Z0; -.
DR NextBio; 34633; -.
DR ArrayExpress; Q969Z0; -.
DR Bgee; Q969Z0; -.
DR CleanEx; HS_TBRG4; -.
DR GO; GO:0005739; C:mitochondrion; IDA:LIFEdb.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0005515; F:protein binding; IPI:IntAct.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0006915; P:apoptosis; IEA:InterPro.
DR GO; GO:0007050; P:cell cycle arrest; TAS:UniProtKB.
DR GO; GO:0000080; P:G1 phase of mitotic cell cycle; TAS:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell proliferation; TAS:UniProtKB.
DR InterPro; IPR013579; FAST_2.
DR InterPro; IPR010622; FAST_Leu-rich.
DR InterPro; IPR013584; RAP.
DR Pfam; PF06743; FAST_1; 1.
DR Pfam; PF08368; FAST_2; 1.
DR Pfam; PF08373; RAP; 1.
DR PROSITE; PS51286; RAP; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Polymorphism.
FT CHAIN 1 631 Protein TBRG4.
FT /FTId=PRO_0000273026.
FT DOMAIN 561 619 RAP.
FT MOD_RES 65 65 Phosphothreonine.
FT MOD_RES 553 553 Phosphoserine.
FT VAR_SEQ 246 355 Missing (in isoform 2).
FT /FTId=VSP_022460.
FT VARIANT 22 22 A -> S (in dbSNP:rs2304694).
FT /FTId=VAR_030071.
FT VARIANT 57 57 P -> L (in dbSNP:rs2304693).
FT /FTId=VAR_030072.
FT CONFLICT 365 365 T -> A (in Ref. 4; BAD96663).
FT CONFLICT 489 489 V -> E (in Ref. 6; AAB69312).
FT CONFLICT 524 524 A -> S (in Ref. 6; AAB69312).
SQ SEQUENCE 631 AA; 70738 MW; 4EFC3AF5D5BBABD3 CRC64;
MAAHLVKRCT CLLREAARQA PAMAPVGRLR LAWVAHKTLT SSATSPISHL PGSLMEPVEK
ERASTPYIEK QVDHLIKKAT RPEELLELLG GSHDLDSNQA AMVLIRLSHL LSEKPEDKGL
LIQDAHFHQL LCLLNSQIAS VWHGTLSKLL GSLYALGIPK ASKELQSVEQ EVRWRMRKLK
YKHLAFLAES CATLSQEQHS QELLAELLTH LERRWTEIED SHTLVTVMMK VGHLSEPLMN
RLEDKCLELV EHFGPNELRK VLVMLAAQSR RSVPLLRAIS YHLVQKPFSL TKDVLLDVAY
AYGKLSFHQT QVSQRLATDL LSLMPSLTSG EVAHCAKSFA LLKWLSLPLF EAFAQHVLNR
AQDITLPHLC SVLLAFARLN FHPDQEDQFF SLVHEKLGSE LPGLEPALQV DLVWALCVLQ
QAREAELQAV LHPEFHIQFL GGKSQKDQNT FQKLLHINAT ALLEYPEYSG PLLPASAVAP
GPSALDRKVT PLQKELQETL KGLLGSADKG SLEVATQYGW VLDAEVLLDS DGEFLPVRDF
VAPHLAQPTG SQSPPPGSKR LAFLRWEFPN FNSRSKDLLG RFVLARRHIV AAGFLIVDVP
FYEWLELKSE WQKGAYLKDK MRKAVAEELA K
//