Документ взят из кэша поисковой машины. Адрес оригинального документа : http://kodomo.cmm.msu.ru/FBB/BasicData/aa_properties/aahydro.doc Дата изменения: Fri Apr 17 18:26:23 2009 Дата индексирования: Tue Aug 18 06:50:55 2009 Кодировка: koi8-r

Существуют разные методы оценки гидрофобности боковых цепей аминокислотных
остатков.
Разные методы дают несколько различающиеся результаты. Вашему вниманию
предлагаются 3 из наиболее популярных шкал гидрофобности
(http://garlic.mefos.hr/split/scales.html)

1.
Eisenberg normalized consensus hydrophobicity values. Average of 5 other
scales.
Selected (H) normalized values as published in:
D. Eisenberg, E. Schwarz, M. Komaromy and R. Wall: " Analysis of Membrane
and
Surface Protein Sequences with the Hydrophobic Moment Plot". J. Mol. Biol.
179 (1984), 125-142.

|Arg |R |-2.53 |
|Lys |K |-1.5 |
|Asp |D |-0.9 |
|Gln |Q |-0.85 |
|Asn |N |-0.78 |
|Glu |E |-0.74 |
|His |H |-0.4 |
|Ser |S |-0.18 |
|Thr |T |-0.05 |
|Pro |P |0.12 |
|Tyr |Y |0.26 |
|Cys |C |0.29 |
|Gly |G |0.48 |
|Ala |A |0.62 |
|Met |M |0.64 |
|Trp |W |0.81 |
|Leu |L |1.06 |
|Val |V |1.08 |
|Phe |F |1.19 |
|Ile |I |1.38 |

2.
Kyte&Doolittle hydropathy values of amino acid residues.
Selected (H) as published in:
J. Kyte and R.F. Doolittle: "A Simple Method for Displaying the
Hydropathic Character of a Protein".
J. Mol. Biol. 157(1982)105-132.

|Arg |R |-4.50 |
|Lys |K |-3.90 |
|Glu |E |-3.50 |
|Gln |Q |-3.50 |
|Asp |D |-3.50 |
|Asn |N |-3.50 |
|His |H |-3.20 |
|Pro |P |-1.60 |
|Tyr |Y |-1.30 |
|Trp |W |-0.90 |
|Ser |S |-0.80 |
|Thr |T |-0.70 |
|Gly |G |-0.40 |
|Ala |A |1.80 |
|Met |M |1.90 |
|Cys |C |2.50 |
|Phe |F |2.80 |
|Leu |L |3.80 |
|Val |V |4.20 |
|Ile |I |4.50 |


3.
Calculated values (H) for hydrophathy based on the transfer of solutes
from water to alkalane solvents.
Free energy changes are corrected for self-solvation.
M.A. Roseman: "Hydrophilicity of Polar Amino Acid Side-chains is
Markedly Reduced by Flanking Peptide Bonds". J. Mol. Biol. 200 (1988),
513-522.

|Arg | -3.8 |
|Lys | -2.46 |
|Asn |-2.27 |
|Gln |-2.12 |
|Glu | -1.78 |
|Asp | -1.57 |
|His |-1.09 |
|Tyr | -0.98 |
|Ser | -0.1 |
|Gly |0 |
|Thr |0.42 |
|Ala |0.67 |
|Cys |1.48 |
|Met | 1.67 |
|Pro | 1.75 |
|Val |2.18 |
|Trp | 2.86 |
|Leu | 3.02 |
|Ile |3.02 |
|Phe | 3.02 |