Документ взят из кэша поисковой машины. Адрес оригинального документа : http://chem.msu.ru/rus/teaching/carcinogenesis/4.pdf Дата изменения: Wed Feb 27 13:27:52 2013 Дата индексирования: Sun Apr 10 17:18:40 2016 Кодировка:


HPV (Human Papillomavirus) ( )
· - - · : ,



· · ~500 000 , ~230 000

2004 12 700 12 100 . 40% - III-IV

21


()


100 30 -
16, 18, 31, 33, 35, 39, 45, 52, 53, 56, 58, 59, 66, 70

-
6, 11, 40, 42, 43,44, 54, 61, 70, 72, 81 ...



(
Hybrid Capture)

)

(




: CIN
CIN CIN CIN 1: 2: 3: ; ; CIS; FIGO 0 CIN 1 CIN 2 CIN 3



Basal cells

All figures reprinted with permission from Frappart, et al. Histopathology and Cytopathology of the Uterine Cervix. Digital Atlas, Lyon, France: IARC Press, 2004.


CIN


CIN CIN CIN

1: 2: 3:

; ; cancer in situ (CIS); FIGO 0 CIN 1 CIN 2 CIN 3

Photo courtesy of Dr. J. Monsonego

Photo courtesy of Dr. J. Monsonego

From IARC, 2003.4


:

From IARC, 2003.

1

Photos courtesy of Dr. J. Monsonego

1. Reprinted with permission from Sellors JW, Sankaranarayanan R, eds. Colposcopy and Treatment of Cervical Intraepithelial Neoplasia. A Beginner's Manual. Lyon, France: International Agency for Research on Cancer; 2003.




6 11 >90% >70% 40%

1. Jansen KU, Shaw AR. Annu Rev Med. 2004;55:319­331. 2. Koutsky L. Am J Med. 1997;102:3­8. 3. Franco EL, Villa LL, Richardson H, Rohan TE, Ferenczy A. In: Franco EL, Monsonego J, eds. Oxford, UK: Blackwell Science; 1997:14­22. 4. Tortolero-Luna G. Hematol Oncol Clin North Am. 1999;13:245­257, x.


-
­ ( 50-100 )
From IARC, 2004.4


70% -

()
( 6,11 )

(, , ) -


(RRP) (RRP)

: 2 - 4 20 - 40 6 11







Photos courtesy of Craig S. Derkay, MD Eastern Virginia Medical School

1. University of Maryland Medicine. Available at: http://www.marylandthoracic.com. Accessed March 29, 2006.