|
Bel'tiukov P. P., Galebskaya L. V., Simkina N. B., Tarasova Y. V.
The function of the human complement cascade
after the proteolytic serum treatment in vitro.
Abstract
Proteolytic treatment of serum with pancreatic
kallikrein leads to decrease of complement-mediated hemolysis velocity and
reduction of hemolytic complement capacity (HCC), mainly in alternative pathway
of complement activation (APC). It was demonstrated in experiments with
purified proteins that changes showed caused by proteolytic degradation of C3
component. Decreasing of functional hemolytic activity was observed after
treatment of C3 with elastase. C1-inhibitor prevents proteolytic splitting of
C3 and increases the level of inhibitory threshold for kallikrein.
Copyright (C) Chemistry Dept., Moscow State University, 2002
|
|
