Äîêóìåíò âçÿò èç êýøà ïîèñêîâîé ìàøèíû. Àäðåñ îðèãèíàëüíîãî äîêóìåíòà : http://brain.bio.msu.ru/papers/Kaplan_Byeon_Timashev_Vstovskii_Park_2006_ZhVysNervDeyat_AutocorrelationStructure_EEG.pdf
Äàòà èçìåíåíèÿ: Fri Aug 10 18:34:30 2007
Äàòà èíäåêñèðîâàíèÿ: Mon Oct 1 20:25:33 2012
Êîäèðîâêà: ISO8859-5
ìüú÷Ôó ×?û?æò ÷æú×÷ùò áæ?ýæó?÷ùûýð, 2006, êãß 56, < 3, â. 389-392

ßÒêãÛÝ
üáô 612.821 + 612.822.3.087

þü÷ôåðù÷Ôó?÷Ô? ðñõæ÷?ð×ùûý? Ô×ýùôùúúæó?åðù÷÷ùò ûýúüôýüú? ??Ù
? 2006 ,,. Ô. ?. ôäÞÜ1, áÚ. Ù. ÕÈÒÜ2, û. þ. ýÛß?Ò,3, Ù. ×. ×âêã,âÝÛØ4, Õ. ü. øÝ2
éÛÑÛãÞã,,ÛÛ ~ÒÞã,ÒÝ Û ÚÛ,ãêÜÀi õãâÝã,âÝã,,ã ,,ãâëâê,ÒÜÜã,,ã ëÜÛ,ÒâÛêÒê Ûß. õ.×. óãßãÜãâã,, úãââÛfl. 2þÝëÞÈêÒê ÞÒÝêãÜÛÝÛ Û ÝãßäÈêÒÜãØ êÒiÜÛÝÛ ?ëÜÇëÝâÝã,,ã Ü^ÛãÜÞÈÜã,,ã ëÜÛ,ÒâÛêÒê, úÒâäëÇÞÛÝ ôãÒfl. 3 ÷ë~Üã-ÛââÞÒã,êÒÞÈâÝÛØ éÛÑÛÝã-iÛßÛ~ÒâÝÛØ ÛÜâêÛêëê Ûß. ó.?. ôäã,. 4 ðÜâêÛêëê iÛßÛ~ÒâÝãØ éÛÑÛÝÛ Ûß. ÷.÷. ûÒßÒÜã, úÔ÷. e-mail: akaplan@mail.ru
øãâêëäÛÞ , ÒÝ^Û 26.08.2005 ,,. øÛÜflê , äÒ~êÈ 12.12.2005 ,,.
1ôéÒ

÷ äÛßÒÒ ÑäÛâÒØ ??Ù 39 ÛâäÀêëÒßÀi ,ÀäãÞÜÒÜ ÝãÞÛ~Òâê,ÒÜÜÀØ ÜÞÛÑ ÛÑßÒÜ~Û,ãâêÛ ,êãÝãÒÞfl^ÛãÜÜãØ âêëÝêëÀ 1-âÒÝëÜÜÀi âÒ,,ßÒÜêã, ??Ù Ü ãâÜã,Ò â,ÜÒÜÛfl äãâêãÒÜÜÀi Þfl êÛi âÒ,,ßÒÜêã, âêëÝêëÜÀi éëÜÝ^ÛØ. × âãäãâê,ÞÒÜÛÛ â âëã,,êÜÀßÛ ??Ù, , ÝãêãÀi äãâÞÒã,êÒÞÈÜãâêÈ ãêâ~Òêã, ÇÀÞ äÒÒßÒ?Ü âÞë~ØÜÀß ãÇÑãß, äãÝÑÜã, ~êã ÇãÞÒÒ ~Òß , 30% âÞë~Ò, ßÒÚë âêëÝêëÜÀßÛ éëÜÝ^ÛflßÛ 1-âÒÝëÜÜÀi âÒ,,ßÒÜêã, ??Ù, â,ÛÜëêÀßÛ ßÒÚë âãÇãØ Ü 1-3 â, ÜÇÞÞÛâÈ âêêÛâêÛ~ÒâÝÛ ÑÜ~ÛßÀÒ ÑÞÛ~Ûfl. ÷ ãâÜã,Ò äãÞë~ÒÜÜÀi ÜÜÀi äÒÞãÚÒÜ ÛÜÒÝâ ÛÑßÒÜ~Û,ãâêÛ ,êãÝãÒÞfl^ÛãÜÜãØ âêëÝêëÀ ??Ù, ÝãêãÀØ ßãÚÒê ÇÀêÈ ÛâäãÞÈÑã,Ü Þfl ã^ÒÜÝÛ éëÜÝ^ÛãÜÞÈÜÀi âãâêãflÜÛØ ßãÑ,, ~ÒÞã,ÒÝ. ôÞ~Ò,ÀÒ âÞã,: ??Ù, ,êãÝãÒÞfl^Ûfl, âê^ÛãÜÜãâêÈ, âêëÝêëÜfl ã,,ÜÛÑ^Ûfl ??Ù.

Function Variability of the Autocorrelation Structure of the Human EEG
A. Ya. Kaplan, Jong-Gil Byeon, S. F. Timashev, G. V. Vstovsky, Byoung-Woo Park
Lomonosov Moscow State University, Russia; Chungbuk National University, School of Electronic and Computer Engineering, Chungcheongbuk-do, Republic of Korea; Karpov Institute of Physical Chemistry, Moscow, Russia; Semenov Institute of Chemical Physics, Russian Academy of Science, Moscow, Russia e-mail: akaplan@mail.ru On an example of records ??Ù of 39 healthy subjects the quantitative analysis of variability of autocorrelation structure of one-second segments EEG swgments was carried out on the basis of comparison of the structural functions constructed for these segments. It was shown that more than 30% of cases, statistically significant differences were observed between the structural functions of successive onesecond EEG segments dhifted by 1-3 s, as compared to surrogate EEGs formed with the tangled random sequence of count points. On the basis of the obtained data, the index of nonstationarity of the EEG autocorrelation structure was proposed. This index can be used for the objective quantitative evaluation of the functional states of the human brain. Key words: EEG, autocorrelation, index of nonstationarity, structural organization of EEG.

ûëßßÜfl ÞÒÝêÛ~ÒâÝfl ÝêÛ,ÜãâêÈ ßãÑ,, ~ÒÞã,ÒÝ, Ò,,ÛâêÛëÒßfl âã âÝÞÈä âêÜêÜÀßÛ ??Ù-ÞÒÝêãßÛ, äÒâê,ÞflÒê âãÇãØ ,ÀâãÝãÞÇÛÞÈÜÀØ âÛ,,ÜÞ, ÝãêãÀØ â ÜÒÝãêãÀß äÛÇÞÛÚÒÜÛÒß ßãÚÜã ââßêÛ,êÈ ÝÝ äãâÞÒã,êÒÞÈÜãâêÈ Ý,ÑÛâê^ÛãÜÜÀi âÒ,,ßÒÜêã,, ÑÒÞÒÜÜÀi ÝããêÝÛßÛ äÒÒiãÜÀßÛ äÒÛãßÛ [1, 3, 8, 10 Û .]. ùêÒÞÈÜÀÒ Ý,ÑÛâê^ÛãÜÜÀÒ âÒ,,ßÒÜêÀ ??Ù ßã,,ëê, êÝÛß ãÇÑãß, âÞëÚÛêÈ ßÝÒßÛ ëâêãØ~Û,Ài ßÛÝãâãâêãflÜÛØ ßãÑ,,, , êãØ ÛÞÛ ÛÜãØ âêÒäÒÜÛ ãêÚÛi éëÜÝ^ÛãÜÞÈÜÀÒ ÇÞãÝÛ ,ÜëêÛßãÑ,,ã,Ài Ò,,ëÞfl^ÛØ [12].

× ÜâêãflÒÒ ,Òßfl âëÒâê,ëê ÑÞÛ~ÜÀÒ ßÒêãÛ~ÒâÝÛÒ äãiãÀ Þfl ,êãßêÛ~ÒâÝã,,ã ,ÀÒÞÒÜÛfl ÝãÞÛ~Òâê,ÒÜÜÀi iÝêÒÛâêÛÝ âÒ,,ßÒÜêÜãØ âêëÝêëÀ ??Ù [3, 7 Û .], ãäÛâÀ,Ûi âêëÝêëÜë ã,,ÜÛÑ^Û êã,,ã âÞãÚÜã,,ã ÇÛãÞã,,Û~ÒâÝã,,ã âÛ,,ÜÞ [10]. ÷ã,ÀÒ êÒiÜãÞã,,ÛÛ ÝãßäÈêÒÜã,,ã ÜÞÛÑ ??Ù, ÑÇãêÜÜÀÒ , õÙü (SECT0.1?, SCAN-0.1? Û JAMPSYN-0.1?), äãÑ,ãÞÛÞÛ âëÒâê,ÒÜÜã â?ÛÛêÈ iÝêÒÛâêÛÝë éëÜÝ^ÛãÜÞÈÜÀi âãâêãflÜÛØ ßãÑ,, ~ÒÞã,ÒÝ , êÒßÛÜi âêëÝêëÜãØ ã,,ÜÛÑ^ÛÛ ??Ù äÛ Ýã,,ÜÛêÛ,ÜÀi [4] Û éßÝãÞã,,Û~ÒâÝÛi [9] Ü,,ëÑÝi, Ü éãÜÒ

389


390

ÝäÞÜ Û .

Üã~Üã,,ã âÜ [11] Û äÛ ÜÒÝãêãÀi äâÛiãäêãÞã,,Ûfli [2, 5]. ùÜÝã ÝÛêÒÛÛ ,ÀÒÞÒÜÛfl âêëÝêëÜÀi ÞÒßÒÜêã, ??Ù , äããÇÜÀi ÛââÞÒã,ÜÛfli ãÇÀ~Üã ãâÜã,À,êâfl Ü êÒi ÛÞÛ ÛÜÀi ßäÞÛêëÜÀi äãÝÑêÒÞfli ??Ù-ÝãÞÒÇÜÛØ. õÒÚë êÒß iãã?ã ÛÑ,ÒâêÜã, ~êã ÛÑßÒÜ~Û,ãâêÈ äãâÞÒã,êÒÞÈÜÀi ãêâ~Òêã, ã^Ûéã,ÜÜã,,ã ??Ù âÛ,,ÜÞ âëÒâê,ÒÜÜã ã,,ÜÛ~ÒÜ Ûi ÑÜ~ÛêÒÞÈÜãØ ,ÑÛßÜãØ âÝãÒÞÛã,ÜÜãâêÈ. × êãØ â,flÑÛ ,ãÑÜÛÝÒê ,ãäãâ: ÜâÝãÞÈÝã ÞÇÛÞÈÜ ,êãÝãÒÞfl^ÛãÜÜfl âêëÝêë ??Ù? õãÚÜã äãÞ,,êÈ, ~êã Ý,ÑÛâê^ÛãÜÜfl ÛÜßÛÝ ßãÑ,,ã,Ài äã^Òââã, ãêÚÒêâfl , êãß ~ÛâÞÒ Û , éëÜÝ^ÛãÜÞÈÜãØ ÛÑßÒÜ~Û,ãâêÛ ,êãÝãÒÞfl^ÛãÜÜã,,ã "ÝÝâ" ??Ù. ñ~ÒØ ÜâêãflÒØ ÇãêÀ ÇÀÞã ÛÑë~ÛêÈ, ÜâÝãÞÈÝã éëÜÝ^ÛãÜÞÈÜãØ fl,ÞflÒêâfl ÛÑßÒÜ~Û,ãâêÈ ,êãÝãÒÞfl^ÛãÜÜãØ âêëÝêëÀ ??Ù, Û ÑÇãêêÈ ÝãÞÛ~Òâê,ÒÜÜÀØ äãÝÑêÒÞÈ, iÝêÒÛÑëÛØ ÛÜêÒÜâÛ,ÜãâêÈ êã,,ã äã^Òââ. õæýùáðôÔ × ÛââÞÒã,ÜÛÛ ÇÀÞÛ ÛâäãÞÈÑã,ÜÀ 2-ßÛÜëêÜÀÒ ÑäÛâÛ ??Ù , ãê,ÒÒÜÛÛ ù1, äãÞë~ÒÜÜÀÒ ë 39 Ñãã,Ài ÛâäÀêëÒßÀi ãÇãÒ,,ã äãÞ äÛ ãêÝÀêÀi ,,ÞÑi. ×âÒ ÑäÛâÛ ??Ù ÇÀÞÛ âÒÞÜÀ Ü âêÜê2() 3.5 3.0 3.5 2.0 3.5 1.0 0.5 0 0.01 0.02 0.03 0.04 0.05 T, c ûþ ûÒ,,ßÒÜê 2 ûþ ûÒ,,ßÒÜê 1

Üãß ÇÛãßÒÛ^ÛÜâÝãß ãÇãëã,ÜÛÛ, , äãÞãâÒ äãäëâÝÜÛfl ãê 0.5 ã 30 Ù^, â äãâÞÒëÒØ ã^Ûéã,ÝãØ â ~âêãêãØ ,ÀÇãÝÛ 128 , 1 â. ôÞââÛ~ÒâÝÛß ÛÜâêëßÒÜêãß ã^ÒÜÝÛ ,ÑÛßÜãØ âÝãÒÞÛã,ÜÜãâêÛ fl âãâÒÜÛi ÑÜ~ÒÜÛØ ??Ù fl,ÞflÒêâfl ,À~ÛâÞÒÜÜfl Þfl êã,,ã fl ,êãÝãÒÞfl^ÛãÜÜfl éëÜÝ^Ûfl. × ÜâêãflÒß âããÇÒÜÛÛ Þfl äflßãØ ã^ÒÜÝÛ ,ÑÛßÜãØ ÛÑßÒÜ~Û,ãâêÛ âãâÒÜÛi ãêâ~Òêã, ??Ù ßÀ ÛâäãÞÈÑã,ÞÛ ãâê,ÒÜÜë ÝãÒÞfl^ÛãÜÜãØ éëÜÝ^ÛÛ âêêÛâêÛÝë ÑÜãâêÜÀi ßãßÒÜêã, ,êãã,,ã äãflÝ ÛÞÛ âêëÝêëÜë éëÜÝ^Û (ûþ) [6]. û ÜÒÝãêãÀß äÛÇÞÛÚÒÜÛÒß ßãÚÜã â~ÛêêÈ, ~êã ûþ ãêÚÒê âêÒäÒÜÈ ,ÑÛßÜãØ ÛÑßÒÜ~Û,ãâêÛ ßäÞÛêëÀ âãâÒÜÛi ãêâ~Òêã, ??Ù. ôÚë ÑäÛâÈ ??Ù äÒ,ÛêÒÞÈÜã ÜãßÛã,ÞÛ äÒÒâ~Òêãß ÑÜ~ÒÜÛØ ÝÚã,,ã 1-âÒÝëÜÜã,,ã ãêÒÑÝ , äãâÞÒã,êÒÞÈÜãâêÈ ~ÛâÒÞ â ÜëÞÒ,Àß âÒÜÛß Û ÒÛÜÛ~ÜãØ ÛâäÒâÛÒØ. áÞÒÒ Þfl äãâÞÒã,êÒÞÈÜÀi 1-âÒÝëÜÜÀi ãêÒÑÝã, ÜãßÛã,ÜÜãØ ??Ù ,Û {h(tk)}, tk = kt (,,Ò t - ?,, ÛâÝÒêÛÑ^ÛÛ ãêâ~Òêã, ??Ù, h(tk) - êÒÝëÒÒ ÑÜ~ÒÜÛÒ ãêâ~Òê ??Ù Ü ßãßÒÜê ,ÒßÒÜÛ tk, k - äãâÞÒã,êÒÞÈÜÀØ ÜãßÒ ãêâ~Òê ??Ù) ,À~ÛâÞflÞÛâÈ âêëÝêëÜÀÒ éëÜÝ^ÛÛ ,êãã,,ã äãflÝ 1 ( ) = ---M
2


k=1

M

[ h( tk ) - h( tk + ) ] ,
2

M = N - /t,

,,Ò ÛÑßÒÜflÞãâÈ ãê 1 ã 8 t, M - ~ÛâÞã ÛÜêÒ,Þã,, äã ÝãêãÀß äãÛÑ,ãÛÞãâÈ ëâÒÜÒÜÛÒ Þfl ,À~ÛâÞÒÜÛfl 2(). áÞfl ~âêãêÀ ÛâÝÒêÛÑ^ÛÛ 128 Ù^ (N = 128, t = 1/128 â) ÛäÑãÜ äÒÒÇã ÑÜ~ÒÜÛØ âããê,Òêâê,ã,Þ ÞÛêÒÞÈÜãâêÛ ,ÒßÒÜÜÀi ÛÜêÒ,Þã, ãê 7.8 ã 62.5 ßâ (Ûâ. 1). ñêÒß Þfl ÝÚã,,ã â,ÜÛ,ÞÛ ÑÜ~ÒÜÛfl ûþ , ÝÚãØ äÒ äãâÞÒã,êÒÞÈÜÀi 1-âÒÝëÜÜÀi âÒ,,ßÒÜêã, ??Ù, ,ÑflêÀi âã â,Û,,ãß T ë,, ãêÜãâÛêÒÞÈÜã ë,, Ü ,ÒÞÛ~ÛÜë ãê 50 ã 400% ÞÛÜÀ âÒ,,ßÒÜêã, â ÛâÝÒêÜãâêÈ 50%. ýÒß âßÀß ã^ÒÜÛ,ÞÛ ÝêÝã,ÒßÒÜÜë ÛÑßÒÜ~Û,ãâêÈ ,êãÝãÒÞfl^ÛãÜÜãØ âêëÝêëÀ âÒÝëÜÜÀi ãêÒÑÝã, ??Ù , äÒÒÞi 3-4 â. ðÜÀßÛ âÞã,ßÛ, ??Ù âÝÜÛã,ÞÛ ßÜã,,ãÝêÜÀß â,ÜÒÜÛÒß ÒÒ 1-âÒÝëÜÜÀi ãêÒÑÝã, , ,ëi ,ÒßÒÜÜÀi ãÝÜi, âÝãÞÈÑflÛi ,ãÞÈ ??Ù â ?,,ãß 1 â Û âßÒÒÜÜÀi ãêÜãâÛêÒÞÈÜã ë,, ë,, Ü T. áÞfl ÝÚã,,ã â,ÜÒÜÛfl âÒ,,ßÒÜêã, ??Ù éÛÝâÛã,ÞÛ ÑÜãâêÛ ûþ ÜÒ Þfl ,âÒi ÑÜ~ÒÜÛØ , êãÞÈÝã Þfl ãÜã,,ã ÛÑ ÜÛi, äÛ Ýãêããß ê ÑÜãâêÈ ÇÀÞ ßÝâÛßÞÈÜãØ (Ûâ. 1). ýÝÛß ãÇÑãß, ÝÚfl ÑäÛâÈ ??Ù Þfl ÜÜã,,ã T iÝêÒÛÑã,ÞâÈ äãÞë~ÒÜÜãØ Þfl ßÜã,,ãÝêÜÀi â,ÜÒÜÛØ âã,ãÝëäÜãâêÈ ÑÜ~ÒÜÛØ ßÝâÛßÞÈÜãØ ÑÜãâêÛ (õú) ûþ. ÷ ãâÜã,Ò ÑÜ~ÒÜÛØ õú ,À~ÛâÞflÞâfl ÛÜÒÝâ ÛÑßÒÜ~Û,ãâêÛ ,êãÝãÒÞfl^ÛãÜÜãØ âêëÝêëÀ (ðôû) ??Ù (âß. ÜÛÚÒ).

úÛâ. 1. ýÛäÛ~ÜÀØ äÛßÒ âêëÝêëÜÀi éëÜÝ^ÛØ (ûþ) Þfl ,ëi 1-âÒÝëÜÜÀi âÒ,,ßÒÜêã, ÜãßÛã,ÜÜãØ ??Ù, â,ÛÜëêÀi ãêÜãâÛêÒÞÈÜã ë,, ë,, Ü 2 â. á,ëâêããÜÜÒØ âêÒÞÝãØ äãÝÑÜã ßÝâÛßÞÈÜãÒ ÑÞÛ~ÛÒ ßÒÚë ,ëßfl ûþ , ÜÜãß âÞë~Ò. øã ,ÒêÛÝÞÛ - ÑÜ~ÒÜÛÒ âêëÝêëÜãØ éëÜÝ^ÛÛ; äã ,,ãÛÑãÜêÞÛ - ,ÒÞÛ~ÛÜÀ â,Û,,ã, ßÒÚë ãêâ~ÒêßÛ ??Ù (), Þfl ÝãêãÀi ,À~ÛâÞflêâfl ÑÜ~ÒÜÛfl âêëÝêëÜãØ éëÜÝ^ÛÛ. Fig. 1. A typical example of structural functions (SF) for two 1-second segments of normalized EEG, shifted to each other on 2 s. The bilateral arrow shows the maximal distinction between two SF in this case. On a vertical line - the value of structural function; on a horizontal line - the value of shifts between EEG points () for which the values of structural function are calculated.

ìüú÷Ôó ×?û?æò ÷æú×÷ùò áæ?ýæó?÷ùûýð êãß 56 < 3 2006


þü÷ôåðù÷Ôó?÷Ô? ðñõæ÷?ð×ùûý? Ô×ýùôùúúæó?åðù÷÷ùò ûýúüôýüú? ??Ù

391

úæñüó?ýÔý? ðûûóæáù×Ô÷ðò øÒ,ÛêÒÞÈÜÀØ ÜÞÛÑ äãÝÑÞ, ~êã âäÒÒÞÒÜÛÒ ,ÒÞÛ~ÛÜ ßÝâÛßÞÈÜÀi ÑÞÛ~ÛØ ßÒÚë ûþ Þfl â,Û,,ã, ßÒÚë âÝãÞÈÑflÛßÛ ,ÒßÒÜÜ ÀßÛ Ä ãÝÜßÛ ãê 100 ã 400% ÞÛÜÀ ãÝÜ äÛßÒÜã ãÛÜÝã,À. øãêãßë Þfl ÞÈÜÒØ?Ò,,ã êÒâêÛã,ÜÛfl ÇÀÞ ,ÀÇÜ â,Û,, ßÒÚë ãÝÜßÛ, ,ÜÀØ 200%, ê.Ò. â,ÜÛ,ÞÛ 1-âÒÝëÜÜÀÒ ãêÒÑÝÛ ??Ù â äãßÒÚëêÝãß ßÒÚë ÜÛßÛ 1 â. × äÒ,ë ã~ÒÒÈ êÒÇã,ÞãâÈ ëâêÜã,ÛêÈ, ÜâÝãÞÈÝã äãÞë~ÒÜÜÀÒ ã^ÒÜÝÛ ÛÑßÒÜ~Û,ãâêÛ ,êãÝãÒÞfl^ÛãÜÜãØ âêëÝêëÀ ??Ù ßã,,ÞÛ ãêÚêÈ ÛßÒÜÜã éëÜÝ^ÛãÜÞÈÜë ÜÒØãÛÜßÛÝë ??Ù, ÜÒ ÑÝãÜãßÒÜãâêÛ âêãiâêÛ~ÒâÝÛi éÞëÝêë^ÛØ ââßêÛ,ÒßÀi ã^ÒÜãÝ, iÝêÒÜÀÒ Þfl âÞë~ØÜÀi ,ÒßÒÜÜ Ài flã,. áÞfl êã,,ã ââ~ÛêÀ,Ä ÞÛ ÑÜ~ÒÜÛfl õú Þfl âëã,,êÜÀi ??Ù, ÝãêãÀÒ äãÞë~ÞÛ ÛÑ ÒÞÈÜÀi ÑäÛâÒØ äëêÒß âêãiâêÛ~ÒâÝã,,ã äÒÒßÒ?Û,ÜÛfl äãâÞÒã,êÒÞÈÜÀi ãêâ~Òêã,. ýÝÛß ãÇÑãß äãÞÜãâêÈ Ñë?ÞâÈ éëÜÝ^ÛãÜÞÈÜfl âêëÝêëÛã,ÜÜãâêÈ ÛâiãÜãØ ??Ù. ÷ Ûâ. 2 äÒâê,ÞÒÜÀ âäÒÒÞÒÜÛfl ÑÜ~ÒÜÛØ õú ûþ Þfl ÒÞÈÜÀi Û âëã,,êÜÀi ??Ù, äãÞë~ÒÜÜÀi Ü ãâÜã,Ò ÜÞÛÑ 2-ßÛÜëêÜÀi ÑäÛâÒØ ??Ù 39 ÛâäÀêëÒßÀi. ôÝ ,ÛÜã, âäÒÒÞÒÜÛfl ÑÜ~ÒÜÛØ õú Þfl ÒÞÈÜÀi Û ÒÝãÒÞÛã,ÜÜÀi ÑäÛâÒØ ??Ù âÛÞÈÜã ÑÞÛ~êâfl: äã~êÛ 99% ÑÜ~ÒÜÛØ õú âëã,,êÜÀi ??Ù ÞÒÚê ÜÛÚÒ ëã,Üfl 0.5, êã,, ÝÝ ÇãÞÒÒ 30% ÑÜ~ÒÜÛØ õú ÒÞÈÜÀi ??Ù äÒ,À?ê êãê ëã,ÒÜÈ. ýÝÛß ãÇÑãß, ßãÚÜã ëê,ÒÚêÈ, ~êã , äÒÒÞi ÜÒâÝãÞÈÝÛi âÒÝëÜ , ??Ù â ãâêêã~Üã ÇãÞÈ?ãØ ,ÒãflêÜãâêÈ äãÛâiãflê ÜÒâÞë~ØÜÀÒ äÒÒâêãØÝÛ ,êãÝãÒÞfl^ÛãÜÜãØ âêëÝêëÀ ??Ù. ?êã ãÑÜ~Òê, ~êã ,ÒßÒÜÜñfl Û,,ßß Û ßäÞÛêë ãêßÒ~ÒÜÜÀi äÒÒâêãÒÝ , ??Ù ãêÚê êÝÛÒ ãâãÇÒÜÜãâêÛ ÛÜßÛÝÛ éëÜÝ^ÛãÜÞÈÜÀi âãâêãflÜÛØ ßãÑ,,, ÝãêãÀÒ, ,ãÑßãÚÜã, ÜÒ äãfl,Þflêâfl , êÛ^ÛãÜÜÀi ßäÞÛêëÜÀi Û âäÒÝêÞÈÜÀi iÝêÒÛâêÛÝi ??Ù. øã,ÒÒÜÛÒ âÛâêÒßêÛ~ÒâÝÛi ÛââÞÒã,ÜÛØ éëÜÝ^ÛãÜÞÈÜãØ ÛÑßÒÜ~Û,ãâêÛ ,êãÝãÒÞfl^ÛãÜÜãØ âêëÝêëÀ ??Ù êÒÇëÒê ÑÇãêÝÛ ëÜÛêÜã,,ã äãÝÑêÒÞfl ÛÜêÒÜâÛ,ÜãâêÛ êãØ ÛÑßÒÜ~Û,ãâêÛ. × ÜâêãflÒØ ÇãêÒ Þfl êÛi ^ÒÞÒØ äÒÞ,,Òêâfl ÛÜÒÝâ ÛÑßÒÜ~Û,ãâêÛ ,êãÝãÒÞfl^ÛãÜÜãØ âêëÝêëÀ (ðôû). × ãâÜã,ë ,À~ÛâÞÒÜÛfl êã,,ã ÛÜÒÝâ äãÞãÚÒÜ äÒ,ÛêÒÞÈÜfl ã^ÒÜÝ âêãiâêÛ~ÒâÝã,,ã äãã,, õú Þfl ÜÜãØ ??Ù, ãäÒÒÞflÒßã,,ã ÝÝ âÒÜÒÒ ÑÜ~ÒÜÛÒ õú Þfl âëã,,êÜã,,ã ÜÞã,, êãØ ??Ù äÞâ ãÜã âêÜêÜãÒ ãêÝÞãÜÒÜÛÒ. ðÜÒÝâ ðôû ãäÒÒÞflÞÛ ÝÝ âÒÜÒÒ ÑÜ~ÒÜÛÒ Üäãã,,ã,Ài ,ÒÞÛ~ÛÜ õú, ,À~ÛâÞÒÜÜãÒ äã ,âÒß â,ÜÒÜÛflß ä âêëÝêëÜÀi éëÜÝ^ÛØ Þfl ÜÜãØ ÑäÛâÛ ??Ù. ù~Ò,ÛÜã, ~êã ~Òß ÇãÞÈ?Ò ÛÜÒÝâ ðôû, êÒß ÇãÞÒÒ ÑÜ~ÛêÒÞÈÜÀßÛ ßã,,ëê â~ÛêêÈâfl ÝêÝã-

% 40 35 30 25 20 15 10 5 0

0.5

ç 0.1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

úÛâ. 2. úâäÒÒÞÒÜÛÒ ÑÜ~ÒÜÛØ ßÝâÛßÞÈÜÀi ÑÜãâêÒØ ßÒÚë âêëÝêëÜÀßÛ éëÜÝ^ÛflßÛ 1-âÒÝëÜÜÀi âÒ,,ßÒÜêã, ÒÞÈÜÀi (êÒßÜÀÒ âêãÞÇÛÝÛ) ÑäÛâÒØ ??Ù Û âëã,,êÜÀi (â,ÒêÞÀÒ âêãÞÇÛÝÛ) ??Ù. áÜÜÀÒ äÛ,ÒÒÜÀ äã ÒÑëÞÈêêß 1092 â,ÜÒÜÛØ. øã ,ÒêÛÝÞÛ ãêÜãâÛêÒÞÈÜfl ãÞfl ÑÜ~ÒÜÛØ ßÝâÛßÞÈÜÀi ÑÜãâêÒØ (õú) Þfl ÝÚã,,ã ÇÛÜ ,,Ûâêã,,ßßÀ, %, äã ,,ãÛÑãÜêÞÛ ëÝÑÜÀ ä,ÀÒ ,,ÜÛ^À ÇÛÜã, ÑÜ~ÒÜÛØ õú , ÛÜêÒ,ÞÒ ãê 0 ã 1.6. ×ÒêÛÝÞÈÜãØ äëÜÝêÛÜãØ ÞÛÜÛÒØ ãêßÒ~ÒÜã ÑÜ~ÒÜÛÒ õú, ,ÜãÒ 0.5 (âß. êÒÝâê). Fig. 2. Distribution of values of the maximal differences between structural functions of 1-second segments of the real EEG records (dark columns) and surrogated EEG data (light columns). The data are given by results of 1092 comparisons. On a vertical line the relative share of the values of maximal differences (õú) for each section of histograms is presented in %, on a horizontal line are specified the right borders of MP values in interval from 0 up to 1.6. The vertical dashed line marks MP values equal to 0.5 (see the text).

,ÒßÒÜÜÀÒ äÒÒâêãØÝÛ ,êãÝãÒÞfl^ÛãÜÜãØ âêëÝêëÀ ÜÜãØ ÑäÛâÛ ??Ù. ÷ Ûâ. 3 , Ý~Òâê,Ò äÛßÒ äÛ,ÒÒÜÀ ÛÜÒÝâÀ ðôû Þfl ??Ù , ãê,ÒÒÜÛÛ ù1 Þfl ,âÒi êÒâêÛã,,?Ûiâfl ÛâäÀêëÒßÀi. ôÝ ,ÛÜã, âëÒâê,ëÒê ãâêêã~Üã ,ÀÚÒÜÜÀØ ßÒÚÛÜÛ,ÛëÞÈÜÀØ ÑÇãâ ã^ÒÜãÝ ??Ù äã êãßë äãÝÑêÒÞ. õãÚÜã ÇÀÞã äÒäãÞãÚÛêÈ, ~êã êãê ÑÇãâ â,flÑÜ â ÛÜÛ,ÛëÞÈÜÀßÛ ,Û^ÛflßÛ ÞÈé-ÝêÛ,ÜãâêÛ ÝÝ ÜÛÇãÞÒÒ ,ÀÚÒÜÜãØ âäÒÝêÞÈÜãØ ÝãßäãÜÒÜêÀ ??Ù. ùÜÝã ÝãÒÞfl^ÛãÜÜÀØ ÜÞÛÑ äãÝÑÞ, ~êã ßÒÚÛÜÛ,ÛëÞÈÜfl ÛÑßÒÜ~Û,ãâêÈ ÛÜÒÝâ ðôû äÝêÛ~ÒâÝÛ ÜÒ â,flÑÜ (r = 0.21; p < 0.05) â âëßßÜãØ ,ÀÚÒÜÜãâêÈ ÞÈé-ÝêÛ,ÜãâêÛ , ??Ù êÒâêÛã,,?Ûiâfl ÛâäÀêëÒßÀi. ùÕûüìáæ÷ðæ úæñüó?ýÔýù× ×ãÑßãÚÜã, ~êã ÑÞÛ~Ûfl , ÛÜÒÝâi ðôû Þfl ÑÜÀi ÛâäÀêëÒßÀi ãêÚê ÛÜÛ,ÛëÞÈÜÀÒ ãâãÇÒÜÜãâêÛ ÝãÝã,ãØ ÜÒØãÛÜßÛÝÛ, äã ÝØÜÒØ ßÒÒ Þfl ãê,ÒÒÜÛfl ù1 Ü éãÜÒ âãâêãflÜÛfl âäãÝãØÜã,,ã Çãâê,ã,ÜÛfl â ãêÝÀêÀßÛ ,,ÞÑßÛ. × êãØ â,flÑÛ ßãÚÜã ãÚÛêÈ, ~êã ÛÑë~ÒÜÛÒ ÑÞÛ~ÛØ ßÒÚë ÛÜÒÝâßÛ ðôû äãÑ,ãÞÛê äãÞë~ÛêÈ Üã,ÀÒ ÜÜÀÒ ã ÛÜßÛÝÒ ÝãÝã,ãØ ÝêÛ,ÜãâêÛ Þfl ÑÜÀi

ìüú÷Ôó ×?û?æò ÷æú×÷ùò áæ?ýæó?÷ùûýð êãß 56 < 3 2006


392 1.6 1.4 1.2 1.0 0.8 0.6 0.4 0.2 0 1 5 9 13 17 21 25 29 33

ÝäÞÜ Û .

ÜÛØ ßãÑ,, ~ÒÞã,ÒÝ , ÜãßÒ Û äÛ äêãÞã,,ÛÛ. øã,ÒÝÒ êã,,ã äÒäãÞãÚÒÜÛfl ÇëÒê äãâ,flÒÜ âÞÒëfl Çãê. ûøðûùô óðýæúÔýüú?
1. ÕãëÜã, õ.×. "ÔÞé,Ûê" ??Ù: êÛäãÞã,,Ûfl âê^ÛãÜÜÀi âÒ,,ßÒÜêã, ??Ù ~ÒÞã,ÒÝ // ðÜÛ,ÛëÞÈÜã-äâÛiãÞã,,Û~ÒâÝÛÒ ÑÞÛ~Ûfl Û ÇÛãÞÒÝêÛ~ÒâÝfl ÝêÛ,ÜãâêÈ ßãÑ,, ~ÒÞã,ÒÝ. õ.: ÷ëÝ, 1988. û. 56- 70. 2. ÕãÛâã, û.×., ôäÞÜ Ô.?., ÙãÇ~Ò,âÝfl ÷.ó., ôãÑÞã, ð.Ô. ÔÜÞÛÑ âêëÝêëÜãØ âÛÜiãÜÜãâêÛ ??Ù äããâêÝã,, âêÛi ââêãØâê,ßÛ ?ÛÑãéÒÜÛ~ÒâÝã,,ã âäÒÝê // þÛÑÛãÞã,,Ûfl ~ÒÞã,ÒÝ. 2005. ý. 3. < 3. û. 1--8. 3. ôäÞÜ Ô.?. ÷Òâê^ÛãÜÜãâêÈ ??Ù: ßÒêããÞã,,Û~ÒâÝÛØ Û ÝâäÒÛßÒÜêÞÈÜÀØ ÜÞÛÑ // üâäÒiÛ éÛÑÛãÞ. ÜëÝ. 1998. ý. 29. < 3. C. 35-55. 4. ôäÞÜ Ô.?., ÕãÛâã, û.×. áÛÜßÛÝ âÒ,,ßÒÜêÜÀi iÝêÒÛâêÛÝ ÞÈé-ÝêÛ,ÜãâêÛ ??Ù ~ÒÞã,ÒÝ , äãÝãÒ Û äÛ Ýã,,ÜÛêÛ,ÜÀi Ü,,ëÑÝi // ìëÜ. ,Àâ?. ÜÒ,. Òflê. 2003. ý. 53. < 1. û. 22-231. 5. ôäÞÜ Ô.?., ÕãÛâã, û.×., ìÒÞÛ,,ã,âÝÛØ ×.Ô. ôÞââÛéÛÝ^Ûfl ??Ù äããâêÝã, äã âäÒÝêÞÈÜÀß Û âÒ,,ßÒÜêÜÀß iÝêÒÛâêÛÝß , ÜãßÒ Û äÛ ââêãØâê,i ?ÛÑãéÒÜÛ~ÒâÝã,,ã âäÒÝê // ìëÜ. ,Àâ?. ÜÒ,. Òflê. 2005. ý. 55. < 4. û. 450--458. 6. ýÛß?Ò, û.þ., ×âêã,âÝÛØ Ù.×. þÞÛÝÝÒ-?ëßã,fl âäÒÝêãâÝãäÛfl , ÜÞÛÑÒ iãêÛ~ÒâÝÛi ,ÒßÒÜÜÀi flã, ÛÜßÛ~ÒâÝÛi äÒÒßÒÜÜÀi Û äãÇÞÒß ãêÜã?ÒÜÛfl "âÛ,,ÜÞ-?ëß" // ?ÞÒÝêãiÛßÛfl. 2003. ý. 39. < 2. û. 149-162. 7. Barlow J.S. Methods of analysis of nonstationary EEGs, with emphasis on segmentation techniques: a comparative review // J. Clin. Neurophysiol. 1985. V. 2. < 3. P. 267-304. 8. Bodenstein G., Schneider W., Malsburg C.V. Computerized EEG pattern classification by adaptive segmentation and probability-density-function classification. Description of the method // Comput. Biol. Med. 1985. V. 15. < 5. P. 297-313. 9. Fingelkurts A.A., Fingelkurts A.A., Kivisaari R., Pekkonen E., Ilmoniemi R.J., Kahkonen S. Local and remote functional connectivity of neocortex under the inhibition influence // Neuroimage. 2004. V. 22. < 3. P. 1390-1406. 10. Jansen B.H., Cheng W.K. Structural EEG analysis: an explorative study // Int. J. Biomed. Comput. 1988. V. 23. <. 3-4. P. 221-237. 11. Kaplan A., Roeschke J., Darkhovsky B., Fell J. Macrostructural EEG characterization based on nonparametric change-point segmentation: application to sleep analysis // J. Neurosci. Methods. 2001. V. 106. < 1. P. 81-90. 12. Lehmann D. Brain electric field mapping and map analysis in psychiatry: The "atoms of thought" // Biol. Psychiatry. 1991. V. 2. P. 391-394. 13. Lopes da Silva F. Neural mechanisms underlying brain waves: from neural membranes to networks // EEG a. Clin. Neurophysiol. 1991. V. 79. < 2. P. 81-93.

37

úÛâ. 3. ðÜÒÝâÀ ÛÑßÒÜ~Û,ãâêÛ ,êãÝãÒÞfl^ÛãÜÜãØ âêëÝêëÀ ??Ù, ,À~ÛâÞÒÜÜÀÒ äã 2-ßÛÜëêÜÀi ÑäÛâflß ??Ù Þfl 39 ÛâäÀêëÒßÀi. ûäÞã?ÜãØ ,,ãÛÑãÜêÞÈÜãØ ÞÛÜÛÒØ Ü Û,,ßßÒ ëÝÑÜã âÒÜÒÒ ÑÜ~ÒÜÛÒ ÛÜÒÝâ ðôû, ,ÜãÒ 0.77 Á 0.03 (Á ã?ÛÇÝ âÒÜÒ,,ã ÑÜ~ÒÜÛfl); øã ,ÒêÛÝÞÛ - ÑÜ~ÒÜÛÒ ÛÜÒÝâ ðôû, äã ,,ãÛÑãÜêÞÛ - ÜãßÒ ÛâäÀêëÒßÀi. Fig. 3. Indexes of variability of the autocorrelation EEG structure calculated on 2-minute EEG records for 39 subjects. On a vertical line - a value of the index of autocorrelation function variability, on a horizontal line - the numbers of examinees. The dark horizontal line on the diagram specifies an average value of the index equal to 0.77 Á 0.03 and dashed horizontal line marks Á standard error deviation.

ãê,ÒÒÜÛØ ??Ù, Þfl ÑÞÛ~ÜÀi éëÜÝ^ÛãÜÞÈÜÀi Û äêãÞã,,Û~ÒâÝÛi âãâêãflÜÛØ Ô,êãÝãÒÞfl^ÛãÜÜÀØ "ÝÝâ" ??Ù, ã~Ò,ÛÜã, ,äãÞÜÒ éëÜÝ^ÛãÜÞÒÜ Û äããÚÒêâfl ÛÜßÛ~ÒâÝÛß iÝêÒãß ßãÑ,,ã,Ài äã^Òââã,, , ÑÜ~ÛêÒÞÈÜãØ ßÒÒ ÒêÒßÛÜÛëÛi êÒÝêãÛ ÝêÛ,ÜãâêÛ ÜÒØãÜÜÀi âÒêÒØ , äÒÒÞi ÜÒÝãêãã,,ã ,ÒßÒÜÜ?,,ã ÛÜêÒ,Þ. øãÞë~ÒÜÜÀÒ ÜÜÀÒ â,ÛÒêÒÞÈâê,ëê ã êãß, ~êã âëÒâê,ëÒê ãâêêã~Üã ,ÀÚÒÜÜfl ÝêÝãâã~Üfl, , ÛäÑãÜÒ ÜÒâÝãÞÈÝÛi âÒÝëÜ, ÛÑßÒÜ~Û,ãâêÈ ,êãÝãÒÞfl^ÛãÜÜãØ âêëÝêëÀ ??Ù, Ýãêãfl ,ÀiãÛê Ñ äÒÒÞÀ ,ãÑßãÚÜãØ âÞë~ØÜãØ ,ÛêÛ,ÜãâêÛ êãØ iÝêÒÛâêÛÝÛ ??Ù, äã ÝØÜÒØ ßÒÒ Þfl ÑêÀÞã~ÜÀi ãê,ÒÒÜÛØ ë ~ÒÞã,ÒÝ, ÜiãflÒ,,ãâfl , âãâêãflÜÛÛ âäãÝãØÜã,,ã Çãâê,ã,ÜÛfl â ãêÝÀêÀßÛ ,,ÞÑßÛ. øã,ÛÛßãßë, ÜÒâÞë~ØÜÀÒ äÒÒâêãØÝÛ âêÒäÒÜÛ ,ÑÛßÜãØ ãÇëâÞã,ÞÒÜÜãâêÛ äãâÞÒã,êÒÞÈÜÀi ãêâ~Òêã, ??Ù ãêÚê éëÜÝ^ÛãÜÞÈÜã ÑÜ~ÛßÀÒ ÛÑßÒÜÒÜÛfl äßÒêã, ÝêÝãâã~ÜãØ ÛÜßÛÝÛ äã^Òââã, ÞãÝÞÈÜãØ ÝãÝã,ãØ âÛÜiãÜÛÑ^ÛÛ [13]. ñÔôó??æ÷ðæ õãÚÜã äãÞ,,êÈ, ~êã ÛÜÒÝâ ÛÑßÒÜ~Û,ãâêÛ ,êãÝãÒÞfl^ÛãÜÜãØ âêëÝêëÀ ??Ù ãÝÚÒêâfl äãÞÒÑÜÀß Þfl ÛééÒÒÜ^ÛÞÈÜã-Û,,ÜãâêÛ~ÒâÝÛi ÛââÞÒã,ÜÛØ ÑÞÛ~ÜÀi éëÜÝ^ÛãÜÞÈÜÀi âãâêãfl-

ìüú÷Ôó ×?û?æò ÷æú×÷ùò áæ?ýæó?÷ùûýð êãß 56 < 3 2006