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Name: Age-related process: all Disease/lifespan ef fect: all Gene: APOE Name: APOE Synonyms: LDLCQ5, LPG, MGC1571, AD2 Type: gene/protein Approved name: apolipoprotein E Reason for selection: longevity association Gene map locus: 19q13.2 Cellular localization: extracellular Tissue specificity: all Age-related alteration: all Clinical diagnostics: yes Data type/inter vention: all Model/organism: human Search

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Close partner: A2M, LRP2, LRP8, MART, NEFM, PLTP Clinical diagnostics Clinical diagnostics: yes External database linksout: Entrez Gene UniProtKB ORF accession Short description GO process: 34 terms HPRD process: transport Detailed description GO function: 11 terms HPRD function: transport activity UCSC Genome browser HPRD RefNet Ensemble OMIM HomoloGene method: ELISA/EIA

sample: serum HGNC KEGG GeneCards GenAtlas CTD

Pathways Interaction database

GO component: 7 terms HPRD molecular class: transport/cargo protein

Entrez gene summary : Chylomicron remnants and ver y low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceriderich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq] UniProtKB/swissProt function: Mediates the binding, internalization, and catabolism of lipoprotein particles. It can ser ve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues. Tissue specificity Aging and longevity associated data Ag ed alt ed alterations: Age-relate-relaterations: Increasing ­ deceasing ­ increasing ­ decreasing corpus callosum ­ rat hypothalamus, cortex-mouse hilus of hippocampus ­ rat plasma-human Age-rAge-related processes: elated processes: Fibrosis lipofuscin accumulation pro-inflammator y cytokine accumulation decreasing of antioxidant enzymes cholesterol accumulation Age-rAge-related diseases: elated diseases: shortening lifespan atherosclerosis Parkinson disease Alzheimer disease Longevity Stroke

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