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Group
is headed by Prof. N.I.Larionova
Research
topics:
1) Development
of drug delivery systems (proteins, oligonucleotides, antioxidants,
anti-inflammatory and antineoplastic
agents) with
improved bioavalability.
- Design of
polymer conjugates,
polymer micelles, microparticles & microcapsules, nanoparticles,
proteoliposomes.
- Mucoadhesive films
- in vitro & in vivo evaluation
2) Serine
proteinases and
their protein
inhibitors
of animal
and plant origin. Isolation, kinetic and
thermodynamic study of
specificity.
Research
cooperation:
In Russia:
- Mendeleev
University of Chemical Technology of Russia. Department of Biotechnology.
Associate Professor Babusenko E.S.
(Protein encapsulation) http://www.muctr.ru/univsubs/infacol/ekolog/faculties/f3
- Mendeleev
University of Chemical Technology of Russia. Professor Shtilman M.I. (Self-assembling
systems based on amphiphilic polymers for medical use) http://www.muctr.ru
- Pavlov State
Medical University of Saint Petersburg.
Professor Galebskaya L.V. (Complement
system)
http://www.spbmedu.ru
- Lomonosov
Moscow state academy of fine chemical technology.
Professor Shvetz V.I., associate
Professor
Sorokoumova G.M. (Lipid- based protein
delivery systems) http://www.mitht.ru
- Department
of Biology, Lomonosov Moscow State University. Dr.
Selishcheva
ю.ю. (Protein/Lipid interations) http://www.bio.msu.ru
- A.N.
Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow
State University. Dr. Spiridiniva V.A. (Oligonucleotide delivery
systems) http://www.genebee.msu.su/
- Scryabin
Moscow Academy of Veterinary Medicine and Biotechnology, Professor
Belousova
R.V. (Antiviral action of protein preparations) http://www.mgavm.ru
- Russian
Academy of Postdiploma Education of Physicians. Member-
Correspondent
RAMS Mashetova L. K.; Chair of Biochemistry, Professor
Jarovaja
G.ю. (Biochemical motivation of using the ocular medicinal films) http://www.ras.ru
- Sechenov
Moscow Medical Academy, Pharmaceutical Faculty. Associate
Professor,
Demina N.B. (Mucoadhesive drug delivery systems) http://www.mma.ru
- Shemyakin and
Ovchinnikov Institute of Bioorganic Chemistry,
Professor Rumsh L.D., Dr. Zamolodchikova T.S. (Regulation of
duodenase activity by proreinase inhibitors) http://portal.ibch.ru
International:
- Universite Paris- Sud, Faculte de
Pharmacie (France).
Professor P. Couvreur,
Professor D. Duchene,
Dr. R. Gref,
Dr. л. Ollivon (Nano-
and microsystems for drug delivery) http://www.u-psud.fr
- Max-Planck Institute of Colloids and
Interfaces,
Golm/Potsdam (Germany). Professor H. Moehwald (Encapsulation of
proteins in polyelectrolyte microparticles) http://www.mpikg-golm.mpg.de
- School of Pharmacy, University of
Southern California, Los
Angeles.(USю). Professor W.-C. Shen (Lipidization of proteins) http://www.usc.edu/schools/pharmacy
Offers
for possible commercialization:
1.
Biodegradable
polymeric films for stomatology (Treatment of paradontitis,
inflammatory
and erosive- ulcerous processes in oral cavity)
2.
Biologically
active additive to food with anticarcinogenic and antitumor activity.
Mail address:
Department of Chemistry,
M.V.Lomonosov Moscow State University,
Moscow 119991, Russia
Phone: +7 495
939-3417
Fax: +7 495
939-5417
e-mail: nilar(at)enzyme.chem.msu.ru
Last update –
01.02.2009
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