... History of Problem Sequence Local Similarity Algorithm of Similarity Calculation Local Similarity Approach Paradigm Algorithm of Protein Function Recognition Prediction Accuracy Estimation Results of Local Similarity Approach Evaluation Acknowledgements The central dogma of SAR/QSAR/QSPR: Property = Function ( Structure ) Continuity hypothesis: the difference of structures is less, the difference of properties is less ypred = x0 + ixiFi(S) Fi(S) = LogP, .. ... Sequence Local Similarity. ...