... Valid p-values for candidate peaks are computed via Monte Carlo simulations of smoothed Poisson sequences, whose background Poisson rates are obtained via linear regression from a Control sample and the local GC content. ... Other candidate p eaks, marked in blue, do not have a significantly higher binding rate in the IP sample than in the Control. ... Thus, as argued by SGA, it is enough to test for high binding rates only at locations that resemble p eaks, that is, local maxima of the smoothed...

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