Main tasks of the increment:

• Launch of two ISS-14 crewmembers and one visiting crew participant VC-11 (USA) by transport manned vehicle Soyuz TMA-9 in flight 13S;
• Docking of Soyuz TMA-9 vehicle to the Instrument Compartment of the Service Module (IC-SM);
• Operational support for loading and undocking of Soyuz TMA-8 from Functional Cargo Block (FGB);
• Relocation of Soyuz TMA-9 vehicle from IC-SM to FGB;
• Operational support for docking of the Space Shuttle in Flight 12A.1;
• Operational support for docking of Progress M-58 to IC-SM and its unloading;
• Operational support for docking of the Space Shuttle in Flight 13A;
• Loading and undocking of Progress M-57 from the Docking Compartment (DC1);
• Operational support for docking of Progress M-59 to DC1 and its unloading;
• Loading and undocking of Progress M-59 from DC1;
• Operational support for docking of Progress M-60 to DC1 and its unloading;
• Loading and undocking of Progress M-58 from IC-SM;
• Support of the Space Station functionality;
• Performance of extravehicular activity: i.e. three US egresses (EVA) on the ISS USOS and two Russian egresses (EVA) on the ISS RS;
• Performance of the science and application research program and experiments (SVS, Crystallizator, Relaksatsia, Uragan, Vsplesk, Ekon, Plasma-ISS, Cardio-ODNT, Profilaktika, Pulse, Pilot, Pnevmocard, Biorisk, Akvarium, Rastenia-2, Statokonia, Regeneration, Prognos, Matroshka-R, Diatomeya, Glikoproteid, Mimetik-K, KAF, Vaktsina-K, Biotrek, Konjugatsia, Biodegradatsia, Bioecologia, Bioemulsiya, Interleikin-K, Antigen, Vector-T, Izgib, Plasma Crystal, Identifikatsiya, Sreda, BTN-Neutron), as well as contract-based commercial activities (GTS, GCF-JAXA, Rokviss, Golf);
• Crew handover to Increment ISS-15 and return of ISS-14 two crewmembers and flight participant under the visiting crew program (VC-12) on Soyuz TMA-9 transport manned vehicle.