Äîêóìåíò âçÿò èç êýøà ïîèñêîâîé ìàøèíû. Àäðåñ îðèãèíàëüíîãî äîêóìåíòà : http://biochem.bio.msu.ru/assets/files/2013_09_27%20Buklet%202013.pdf Äàòà èçìåíåíèÿ: Fri Sep 27 17:45:05 2013 Äàòà èíäåêñèðîâàíèÿ: Thu Feb 27 20:53:16 2014 Êîäèðîâêà: Ïîèñêîâûå ñëîâà: hydrogen

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- . 60- ­ 70- , , , G-, . 1977 .. .. , .. .. . - (.. ), .. (.. ), G.. (.. , . , .. , .. ), (.. , .. ). 80- NO- (.. ) (.. , .. ). , (.. , .. , .. ). , . , . / , (.. , .. ), (.. , .. , .. ), (.. , .. , .. ), , (.. , .. ), (.. , .. , .. ), , (.. , .. , .. ), (.. , .. , .. , .. ), (.. , .. , .. ). , , . .. , .. , .. , .. , .. , .. .. . 6 , 2 , . 14 , , 4 , 5 , 3 , .

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, .. . . .. - , « » (2009), « » (2010), « » (1979 1989). .. . 150
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- , ... .. 60- , , , . 70 .. ( ) : . . ( ), . . ( ) . . ( , -); 1980 . - . 40 . . : 1) 2+ (1972 .); 2) (1979 .); 3) 2+- (1972 .); 4) - S-3 II (1975); 5) ­ (1988); 6) ADP FoF1 (1980); 7) I (1990 .); 8) I (1999); 9) (1977; 1983 .); 10) -
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NADH:- (1989 .); 11) - ­ , (2010 .). . «» , ­ FoF1-. , , , . , - , , , . ­ , NADH:- ( I). I, -, , . , . ­ - . , , , « , . - : 1991 . . ­ .. 10 . 2001 . , . .. «» III - ; .. « » - IV ; .. « » IV . .. ­ - , «», , «» "Acta Biochimica Polonica", « ». .. ­ « ». .. .. ­ , . .. . 24 , . .. .. .

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, : 1. 2. 3. 4. 5. Zharova T.V., Vinogradov A.D. Energy-dependent Transformation of F0·F1-ATPase in Paracoccus denitrificans Plasma Membranes (2004) J. Biol. Chem. 279, 12319-12324. Zharova T.V., Vinogradov A.D. Energy-linked binding of Pi is required for continuous steady-state proton-translocating ATP hydrolysis catalyzed by F0·F1 ATP synthase (2006) Biochemistry 45, 1455214558. Grivennikova, V.G., Gladyshev, G.V., Vinogradov, A.D. Allosteric nucleotide-binding site in the mitochondrial NADH:ubiquinone oxidoreductase (respiratory complex I). (2011) FEBS Lett. 585, 22122216. Kareyeva A.V., Grivennikova V.G., Vinogradov A.D. Mitochondrial hydrogen peroxide production as determined by the pyridine nucleotide pool and its redox state (2012) Biochim. Biophys. Acta 1817, 1879-1885. Grivennikova V.G., Vinogradov A.D. Partitioning of superoxide and hydrogen peroxide production by mitochondrial respiratory complex I (2013) Biochim. Biophys. Acta 1827, 446-454.

: : 156, 158, 160 .. .. .. .. ..

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­ , .-. , , ... . , . , . , . , . , , - , . 14-3-3, -. , , - 14-3-3. , , , , 14-3-3. , HspB6 14-3-3, . . HspB1, HspB5, HspB6, HspB8, . , . , .
20

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15 . (, , ). , , , Wellcome Trust. , , .. (.. , .. , .. , .. , .. ), (.. , .. , .. ), , (.. , .. , .. , .. , .. ), (.. , .. ), (.. ) (.. , .. ).

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, , : 1. Sluchanko N.N., Sudnitsyna M.V., Seit-Nebi A.S., Antson A.A., Gusev N.B.. Properties of the monomeric form of human 14-3-3 protein and its interaction with tau and HspB6. (2011) Biochemistry 50(45):9797-9808. 2. Mymrikov E.V., Seit-Nebi A.S., Gusev N.B.. Large potentials of small heat shock proteins. (2011) Physiol Rev. 91(4):1123-1159. 3. Sudnitsyna M.V., Seit-Nebi A.S., Gusev N.B.. Cofilin weakly interacts with 14-3-3 and therefore can only indirectly participate in regulation of cell motility by small heat shock protein HspB6 (Hsp20). (2012) Arch Biochem Biophys. 521(1-2):62-70. 4. Datskevich P.N., Mymrikov E.V., Gusev N.B.. Utilization of fluorescent chimeras for investigation of heterooligomeric complexes formed by human small heat shock proteins. (2012) Biochimie. 94(8):17941804 5. .., .., .., .. . (2012) () 77 (13): 1500-1514. 6. Sluchanko N.N., Gusev N.B.. Oligomeric structure of 14-3-3 protein: what do we know about monomers? (2012) FEBS Lett. 586(24):4249-4256.. 7. Nefedova V.V., Datskevich P.N., Sudnitsyna M.V., Strelkov S.V., Gusev N.B.. Physico-chemical properties of R140G and K141Q mutants of human small heat shock protein HspB1 associated with hereditary peripheral neuropathies. (2013) Biochimie. 95(8):1582-1592 : , 128 .. .. .. .. .. ..

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, , . . , , (, , ). , , 0 º. , . .. « », , . 139

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ADP . (, , , ) . . , , , . , 25% . - . . , , , . , . , , 9% , . , , - . ; . , . . ( , ). ; , , . . : ..., c... .. ... ..

: 1. .. , .. . (2003) , 68, 1412 ­ 1422. 2. .. , .. . (2005) , 70, 1646 ­ 1655. 3. .. , .. . : , (2008) , 73, 395 ­ 407. 4. .. , .. . (2009) , 74, 710 ­ 720. 5. .. , .. . ( ), , 10% , , (2012) 77, 731 ­ 741.
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Na,K-
- , ... Na,K-P (Na-) ­ , Na K . 1957 . 1997 . Na,K-P 1967 .. . . - Na,K-P. , Na,K-P . , . (, ) . Na,K-P (, + 2+) (, ). , , Na,K P , , ( ). , , , . , Na,K-P, . Na + Na/Ca-, 2+. , , . Na,K-P. Src- . Src- GTP- , , , . . Na,KP , Na,K-P, , , , Erk- . , , , Na,K-P , . , Na,K-P Na,K -P, . , , , . , , , Na,K -P, , . SH- Na,K-. : . - , . , 13 15 SH -
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Na,K-P. SH-, , . SH-. , Na,K-P 40% . , SH-, Na,K-P, , . , SH - Na,K-P, . , SH- Na,K-P , , , . 136 138. - , , , . 6 . : , . 20 , ( INTAS). , ( ), ( , ). , , : 1. Yakushev S, Mitkevich V.A., Kamanina Y.V., Ziganshin R.H., Meng X, Anashkina A.A., Makhro A, Lopina O.D., Gassmann M, Makarov A.A., Bogdanova A., Petrushanko I.Y.. S-glutathionylation of the Na,K-ATPase catalytic subunit is a determinant of the enzyme redox sensitivity. (2012) J Biol Chem.;287(38):32195-205. 2. Akimova O.A., Lopina O.D., Rubtsov A.M., Hamet P, Orlov S.N.. Investigation of mechanism of p38 MAPK activation in renal epithelial cell from distal tubules triggered by cardiotonic steroids. (2010) Biochemistry (Mosc). 75(8):971-8. 3. Akimova O.A., Lopina O.D., Rubtsov A.M., Gekle M, Tremblay J, Hamet P, Orlov S.N.. Death of ouabain-treated renal epithelial cells: evidence for p38 MAPK-mediated Na (i) (+) /K (i) (+) -independent signaling. (2009) Apoptosis. 14(11):1266-73. 4. Akimova O.A., Lopina O.D., Tremblay J, Hamet P, Orlov S.N.. Altered phosphorylation of RRXS*/T* motif in ouabain-treated renal epithelial cells is not mediated by inversion of the [Na](i)/[K+](i) ratio. (2008) Cell Physiol Biochem. 21(4):315-24. 5. Akimova O.A., Lopina O.D., Hamet P, Orlov S.N.. Search for intermediates of Na+,K+-ATPasemediated [Na+]i/[K+]i-independent death signaling triggered by cardiotonic steroids. (2005) Pathophysiology. 12(2):125-35. 6. Akimova O.A., Bagrov A.Y., Lopina O.D., Kamernitsky A.V., Tremblay J, Hamet P, Orlov S.N.. Cardiotonic steroids differentially affect intracellular Na+ and [Na+]i/[K+]i -independent signaling in C7MDCK cells. (2005) J Biol Chem. 280(1):832-9. 7. Pchejetski D, Taurin S, Der Sarkissian S, Lopina O.D., Pshezhetsky A.V., Tremblay J, deBlois D, Hamet P, Orlov SN. Inhibition of Na+,K+-ATPase by ouabain triggers epithelial cell death independently of inversion of the [Na+]i/[K+]i ratio. (2003) Biochem Biophys Res Commun. 301(3):735-44.

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: - 136, 138 ..., ... .. .. .. ..

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­ , ... - . , - , , , , . ­ ( I ), FABP; , - D-; ; -, IGFBP-4 , . , . , ­ ­ ( , ... .. ), . , (- ) , . , , , , - , - , . ( , ) - . - , - . . . . , . ­ .
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, , : 1. Semenov A.G., Tamm N.N., Seferian K.R., Postnikov A.B., Karpova N.S., Serebryanaya D.V., Koshkina E.V., Krasnoselsky M.I., Katrukha A.G. Processing of pro-B-Type Natriuretic Peptide: Furin and Corin as candidate convertases, Clinical Biochemistry (2010), V. 56, N 7, 1166-76, 2. Semenov A.G., Seferian K.R.. Biochemistry of the human B-type natriuretic peptide precursor and molecular aspects of its processing Clinica Chimica Acta (2011), V. 412, pp. 850-860, 3. Solovyeva T.I., Postnikov A.B., Kharitonov A.V., Tryshina Y.A., Malanichev R.V., Arutyunov A.G., Murakami M.M., Apple F.S., Bereznikova A.V., Katrukha A.G. N-terminal and C-terminal fragments of IGFBP-4 as new markers for short-term risk assessment of major adverse cardiac events (MACE) in patients presenting with ischemia, Clinical Chemistry (2011), Vol. 57, No. 10, Supplement, 4. Altshuler E.P., Vylegzhanina A.V., Katrukha I.A., Bereznikova A.V., Serebryanaya D.V. Application of recombinant antibody fragments for troponin I measurements Biochemistry (Mosc). (2012); 77(12):1362-7. : , ... .. , ... .. , ... .. , ... .. , ... .. , ... .. , .. .. .. , .. 129, 131

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